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(CDK9-IN-30)

1

Identification

CDK9-IN-30 CDK9-IN-30
Name CDK9-IN-30
Formula C28H40ClN5OS
MW 530.17
CAS No.
EINECS
Smiles C1(NC2=NC=C(Cl)C(C3=CSC(NCC4C5C[[email protected]@]6([H])C[[email protected]@H]4C[[email protected]]([H])(C6)C5)=N3)=C2)CCC(NCCOC)CC1 |&1:17,20,22|
Synonyms Compound 36
InChI InChI=1S/C28H40ClN5OS/c1-35-7-6-30-21-2-4-22(5-3-21)33-27-13-23(25(29)15-31-27)26-16-36-28(34-26)32-14-24-19-9-17-8-18(11-19)12-20(24)10-17/h13,15-22,24,30H,2-12,14H2,1H3,(H,31,33)(H,32,34)/t17-,18+,19-,20?,21?,22?,24?
2

Introduction

CDK9-IN-30 (Compound 36) is a highly selective and potent CDK9 kinase inhibitor with an IC50 of 0.094±0.004 μM. CDK9 is a key regulator of transcription elongation in eukaryotic cells and has been considered as a potential drug target for several diseases including cardiac hypertrophy and certain cancers such as a variety of blood cancers as well as solid tumors.

Background Information

3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB100167118

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of CDK9-IN-30

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AMEDCHEM CHINA
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Related Products

Other Forms of

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

CDK9-IN-30

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