Welcome to eBiochemicals.
Directory
| Smiles | O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl |
|---|---|
| Synonyms | CAY-10572 hydrochloride; 2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one hydrochloride |
| InChI | InChI=1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H |
PHA-767491 (CAY10572) Hcl is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 values of 10/34 nM.
| PHA-767491 hydrochloride is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor, which prevents initiation of DNA replication. It inhibits cell proliferation in a variety of human cell lines and induces apoptosis in a p53-independent manner in vivo. It als ......by BOC Sciences |
| PHA-767491 is a potent and selective ATP-competitive dual cdc7/cdk9 inhibitor. ......by BioVision, Inc., |
| PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. ......by MedChemexpress Co., Ltd. |
| PHA-767491, also known as CAY10572, is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. PHA-767491 in combination with 5-FU exhibited much stronger cytotoxicity and induced significant apoptosis manifested by remarkably increased caspase 3 activation and poly(ADP-Ribose) polymerase fragmentation in HCC cells. PHA-767491 directly counteracted the 5-FU-induced phosphorylation of Chk1, a substrate of Cdc7; and decreased the expression of the anti-apoptotic protein myeloid leukemia cell 1, a downstream target of Cdk9. ......by MedKoo Biosciences, Inc. |
| PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2. ......by Selleck Chemicals LLC |
| Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC50 ~ 0.86 - 5.87 μM) and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2) (IC50 = 171 nM). ......by Tocris Bioscience Inc. |
| Appearance:Light yellow to yellow Solid | EBNumber:EB000071830 |
| 4°C | by MedChemexpress Co., Ltd. |
| Desiccate at RT | by Tocris Bioscience Inc. |
| 100 mM in water ； 100 mM in DMSO ； | by CHEMSCENE, LLC |
| 100 mM in water ； 100 mM in DMSO ； | by MedChemexpress Co., Ltd. |
| Soluble to 100 mM in water and to 100 mM in DMSO | by Tocris Bioscience Inc. |
| Product Name | Sponsor & Collaborators | Indications | Start Date | End Date | Phase |
|---|---|---|---|---|---|
| PHA-767491 (hydrochloride) | - | Not Found | |||
| PHA-767491 (hydrochloride) | - | No Development Reported |
| Company | Price and Availability | Country/Region |
|---|---|---|
| Ark Pharm, Inc. | USA | |
| BLD Pharmatech | ||
| BOC Sciences | ||
| BioVision, Inc., | USA | |
| Biochempartner Co., Ltd | China | |
| CHEMSCENE, LLC | 10mg/USD86();50mg/USD355() | USA |
| MedChemexpress Co., Ltd. | 10mg/USD86();50mg/USD355() | USA |
| MedKoo Biosciences, Inc. | USA | |
| Selleck Chemicals LLC | USA | |
| Shanghai Haoyuan Chemexpress Co., Ltd. | 10mg/USD86();50mg/USD355() | China |
| Tocris Bioscience Inc. | USA |
| Name | CAS No | Formula | MW |
|---|---|---|---|
| PHA-767491 | 845714-00-3 | C12H11N3O | 213.24 |
| Name | CAS No | Formula | MW |
|---|---|---|---|
| LY2857785 | 1619903-54-6 | C26H36N6O | 448.6 |
| THZ2 | 1604810-84-5 | C31H28ClN7O2 | 566.0527 |
| Palbociclib (isethionate) | 827022-33-3 | C26H35N7O6S | 573.66 |
| CDK9-IN-6 | 1391855-95-0 | C27H37ClN6O2 | 513.07468 |
| ML167 | 1285702-20-6 | C19H17N3O3 | 335.36 |
| AMG 925 | 1401033-86-0 | C26H29N7O2 | 471.55 |
| LDC000067 | 1073485-20-7 | C18H18N4O3S | 370.43 |
| LEE011 (succinate hydrate) | 1374639-79-8 | C27H38N8O6X | 570.64 |
| LEE011 (succinate) | 1374639-75-4 | C27H36N8O5 | 552.63 |
| LEE011 (hydrochloride) | 1211443-80-9 | C23H31ClN8O | 471.0 |
| LEE011 | 1211441-98-3 | C23H30N8O | 434.54 |
| WHI-P180 (hydrochloride) | 153437-55-9 | C16H16ClN3O3 | 333.77 |
| Wogonin | 632-85-9 | C16H12O5 | 284.26 |
| 1-NM-PP1 | 221244-14-0 | C20H21N5 | 331.41 |
| WHI-P180 | 211555-08-7 | C16H15N3O3 | 297.31 |
| THZ1 | 1604810-83-4 | C31H28ClN7O2 | 566.05 |
| Senexin A | 1366002-50-7 | C17H14N4 | 274.32 |
| CDK4-IN-1 | 1256963-02-6 | C22H29ClN8 | 440.97 |
| Palbociclib (hydrochloride) | 827022-32-2 | C24H30ClN7O2 | 483.99 |
| Purvalanol B | 212844-54-7 | C20H25ClN6O3 | 432.9 |
| Name | CAS No | Formula | MW |
|---|
|
Anderson et al (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J.Med.Chem. 50 2647. PMID: 17480064. Jackson (2008) Stopping replication, at the beginning. Nature Chem.Biol. 4 331. Montagnoli et al (2008) A cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumour activity. Nature Chem.Biol. 4 357. ......by Tocris Bioscience Inc. |
