• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1214265-56-1 (WZ-3146)

1

Identification

WZ-3146 WZ-3146
Name WZ-3146
Formula C24H25ClN6O2
MW 464.95
CAS No. 1214265-56-1
EINECS
Smiles CN1CCN(C2=CC=C(C=C2)NC3=NC=C(C(OC4=CC(NC(C=C)=O)=CC=C4)=N3)Cl)CC1
Synonyms WZ3146;WZ 3146; N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide
InChI InChI=1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
2

Introduction

WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). IC50 value: 2 nM/2 nM (EGFR L858R/E746_A750) [1] Target: Mutant EGFR WZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del E746_A750 containing HCC827 cells, 15 nM in EGFR Del E746_A750 containing PC9 cells, 29 nM in EGFR L858R/T790M containing H1975 cells and 3 nM in EGFR Del E746_A750/T790M containing PC9 GR cells.

Background Information

WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). IC50 value: 2 nM/2 nM (EGFR L858R/E746_A750) [1] Target: Mutant EGFR WZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del E746_A750 containing HCC827 cells, 15 nM in EGFR Del E746_A750 containing PC9 cells, 29 nM in EGFR L858R/T790M containing H1975 cells and 3 nM in EGFR Del E746_A750/T790M containing PC9 GR cells. ......by MedChemexpress Co., Ltd.
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). ......by Selleck Chemicals LLC
WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I). ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Cell lines NSCLC and Ba/F3 cells
Conditions 0-10 μM; 72 hours
Method Growth and inhibition of growth is assessed by MTS assay. NSCLC or Ba/F3 cells are exposed to treatment for 72 hours and the number of cells used per experiment is determined empirically. All experimental points are set up in six to twelve wells and all experiments are repeated at least three times. The data is graphically displayed using GraphPad Prism version 5.0 for Windows. The curves are fitted using a non-linear regression model with a sigmoidal dose response.
Source Selleck Chemicals LLC

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000029055

Storage condition

Solubility

DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥2.8mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 93 mg/mL (200.02 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
WZ-3146 - No Development Reported
7

Safety Data of WZ-3146

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
CHEMSCENE, LLC 5mg/USD136(Get quote);10mg/USD256(Get quote);50mg/USD770(Get quote);100mg/USD1370(Get quote) USA
MedChemexpress Co., Ltd. 5mg/USD136(Get quote);10mg/USD256(Get quote);50mg/USD770(Get quote);100mg/USD1370(Get quote) USA
Selleck Chemicals LLC 5mg/USD170(In stock);10mM/1mLIn DMSO/USD320(In stock);50mg/USD970(In stock);200mg/USD2470(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD136(Get quote);10mg/USD256(Get quote);50mg/USD770(Get quote);100mg/USD1370(Get quote) China
Target Molecule Corp. 5mg/USD67();100mg/USD348() USA
10

Related Products

Other Forms of 1214265-56-1

Name CAS No Formula MW

Recommended Compounds in EGFR

Name CAS No Formula MW
Ginsenoside Rh2 78214-33-2 C36H62O8 622.87
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 445.56
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 595.71
Mutant EGFR inhibitor 1421373-62-7 C27H30ClN7O2 520.03
AZD-9291 1421373-65-0 C28H33N7O2 499.61
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
WHI-P180 211555-08-7 C16H15N3O3 297.31
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 483.36
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 489.54
BGB-102 807640-87-5 C22H25BrN4O2 457.36
Poziotinib 1092364-38-9 C23H21Cl2FN4O3 491.34
CO-1686 (hydrobromide) 1446700-26-0 C27H29BrF3N7O3 636.46
CO-1686 1374640-70-6 C27H28F3N7O3 555.55
CNX-2006 1375465-09-0 C26H27F4N7O2 545.53
PD 168393 194423-15-9 C17H13BrN4O 369.22
AG 18 118409-57-7 C10H6N2O2 186.17
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 718.08
Chrysophanic acid 481-74-3 C15H10O4 254.24
AG-1478 153436-53-4 C16H14ClN3O2 315.75
Mubritinib 366017-09-6 C25H23F3N4O2 468.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

WZ-3146

Tags: buy 1214265-56-1 IC50 | 1214265-56-1 price | 1214265-56-1 cost | 1214265-56-1 solubility | 1214265-56-1 purchase | 1214265-56-1 manufacturer | 1214265-56-1 research buy | 1214265-56-1 order | 1214265-56-1 MSDS | 1214265-56-1 chemical structure | 1214265-56-1 Storage condition | 1214265-56-1 molecular weight | 1214265-56-1 mw | 1214265-56-1 datasheet | 1214265-56-1 supplier | 1214265-56-1 cell line | 1214265-56-1 NMR | 1214265-56-1 MS | 1214265-56-1 IR | 1214265-56-1 solubility | 1214265-56-1 Safe information | 1214265-56-1 Qc and Spectral Information | 1214265-56-1 Clinical Information | 1214265-56-1 Clinical Trial | 1214265-56-1 Route of Synthesis | 1214265-56-1 storage condition | 1214265-56-1 diseases and conditions | 1214265-56-1 flash point | 1214265-56-1 boiling point | 1214265-56-1 melting point | 1214265-56-1 storage condition | 1214265-56-1 brand