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104121-92-8 (Eldecalcitol)

1

Identification

Eldecalcitol Eldecalcitol
Name Eldecalcitol
Formula C30H50O5
MW 490.72
CAS No. 104121-92-8
EINECS
Smiles O[[email protected]]1[[email protected]@H](OCCCO)[[email protected]](O)C(/C(C1)=CC=C2[[email protected]]3([H])CC[[email protected]]([[email protected]](C)CCCC(C)(O)C)[[email protected]@]3(C)CCC2)=C
Synonyms ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3; (1R,2R,3R,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol
InChI InChI=1S/C30H50O5/c1-20(9-6-15-29(3,4)34)24-13-14-25-22(10-7-16-30(24,25)5)11-12-23-19-26(32)28(27(33)21(23)2)35-18-8-17-31/h11-12,20,24-28,31-34H,2,6-10,13-19H2,1,3-5H3/b22-11+,23-12-/t20-,24-,25+,26-,27-,28-,30-/m1/s1
2

Introduction

Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density.

Background Information

Eldecalcitol, a vitamin D analog, has strong effects to reduce calcium reabsorption into the body from bones, therefore increasing bone mineral density, and to increase calcium absorption in intestines. ......by BOC Sciences
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028803

Storage condition

Solubility

5

Mechanism and Indication

Signaling Pathways Others
Target VD/VDR
Research Area Others
Indications Osteoporosis
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Eldecalcitol - Launched
Eldecalcitol Chugai Pharmaceutical Co Ltd Osteoporosis 2004/9/30 2008/10/31 Phase 3 Clinical
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Safety Data of Eldecalcitol

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1mg/USD1850() USA
MedChemexpress Co., Ltd. 1mg/USD1850() USA
Shanghai Changyan Chem & Tech Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 1mg/USD1850() China
10

Related Products

Other Forms of 104121-92-8

Name CAS No Formula MW

Recommended Compounds in VD/VDR

Name CAS No Formula MW
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 416.64
(24R)-MC 976 112828-09-8 C27H42O3 414.62
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 416.64
Calcitriol Impurities D 103656-40-2 C28H46O3 430.663
Calcifediol (monohydrate) 63283-36-3 C27H44O2 400.64
Cholecalciferol 67-97-0 C27H44O 384.64
(24S)-MC 976 112849-14-6 C27H42O3 414.62
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol C39H68O3Si2 641.1264
VD3-D6 118584-54-6 C27H38D6O 390.67
VD2-D3 1217448-46-8 C28H41D3O 399.67
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 418.68
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 434.68
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 430.62
Cholecalciferol 67-97-0 C27H44O 384.63766
Calcitriol Impurities A 73837-24-8 C27H44O3 416.6365
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 910133-70-9 C27H40O3 412.6047
Paricalcitol 131918-61-1 C27H44O3 416.64
MC 976 129831-99-8 C27H42O3 414.62
24R-Calcipotriol 112827-99-3 C27H40O3 412.6
MC 1046 126860-83-1 C27H38O3 410.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
Toremifene (Citrate) 89778-27-8 C32H36ClNO8 598.08
Alfacalcidol 41294-56-8 C27H44O2 400.64
Odanacatib 603139-19-1 C25H27F4N3O3S 525.56
MK-0773 606101-58-0 C27H34FN5O2 479.59
Strontium Ranelate 135459-87-9 C12H6N2O8SSr2 513.49
Alendronate (sodium hydrate) 121268-17-5 C4H18NNaO10P2 325.12
VITAMIN K1 12001-79-5 C31H46O2 450.7
vitamin K1 84-80-0 C31H46O2 450.7
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Route of Synthesis

12

References

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More Information

Eldecalcitol

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