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625115-55-1 (Riociguat)

1

Identification

Riociguat Riociguat
Name Riociguat
Formula C20H19FN8O2
MW 422.42
CAS No. 625115-55-1
EINECS
Smiles FC1=CC=CC=C1CN2C3=NC=CC=C3C(C4=NC(N)=C(C(N)=N4)N(C)C(OC)=O)=N2
Synonyms BAY 63-2521; BAY 632521; methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate
InChI InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
2

Introduction

Riociguat (BAY 63-2521) is a stimulator of soluble guanylate cyclase (sGC). IC50 value: Target: sGC stimulator Riociguat (BAY 63-2521; BAY 632521) is a novel drug that is currently in clinical development by Bayer.

Background Information

Riociguat (BAY 63-2521) is a stimulator of soluble guanylate cyclase (sGC). IC50 value: Target: sGC stimulator Riociguat (BAY 63-2521; BAY 632521) is a novel drug that is currently in clinical development by Bayer. At the moment Phase III clinical trials investigate the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators. ......by MedChemexpress Co., Ltd.
Riociguat (BAY 63-2521) is a novel drug that is currently in clinical development by Bayer. It is a stimulator of soluble guanylate cyclase (sGC). At the moment Phase III clinical trials investigate the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators. (source: http://en.wikipedia.org/wiki/Riociguat). Shelf life: >2 years if stored properly Drug formulation: This drug may be formulated in DMSO ......by MedKoo Biosciences, Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028582

Storage condition

Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. by MedKoo Biosciences, Inc.

Solubility

DMSO by MedChemexpress Co., Ltd.
Soluble in DMSO, not in water by MedKoo Biosciences, Inc.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Riociguat Bayer AG Chronic thromboembolic pulmonary hypertension 2013/2/4 Phase 3 Clinical
Riociguat Bayer AG Pulmonary hypertension 2009/7/31 2014/9/30 Phase 3 Clinical
Riociguat Bayer AG Pulmonary hypertension 2009/3/31 2014/9/30 Phase 3 Clinical
Riociguat Bayer AG Chronic thromboembolic pulmonary hypertension 2009/2/28 2012/6/30 Phase 3 Clinical
Riociguat Bayer AG Pulmonary artery hypertension 2008/12/31 2012/5/31 Phase 3 Clinical
Riociguat - Pre-registration
Riociguat - Launched
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Safety Data of Riociguat

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
CHEMSCENE, LLC 5mg/USD60(In stock);10mg/USD90(In stock);50mg/USD240(In stock) USA
MedChemexpress Co., Ltd. 5mg/USD60(In stock);10mg/USD90(In stock);50mg/USD240(In stock);100mg/USD400(In stock);200mg/USD640(In stock) USA
MedKoo Biosciences, Inc. USA
Pure Chemistry Scientific Inc. 1g/USD59(In stock) USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD70(In stock);10mg/USD135(In stock);50mg/USD405(In stock) China
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Related Products

Other Forms of 625115-55-1

Name CAS No Formula MW

Recommended Compounds in Guanylate Cyclase

Name CAS No Formula MW
Lificiguat 170632-47-0 C19H16N2O2 304.34
Cinaciguat 329773-35-5 C36H39NO5 565.7
Vericiguat 1350653-20-1 C19H16F2N8O2 426.38
Linaclotide 851199-59-2 C59H79N15O21S6 1526.74
BAY 41-2272 256376-24-6 C20H17FN6 360.39
Cinaciguat (hydrochloride) 646995-35-9 C36H40ClNO5 602.16

Recommended Compounds in Same Indication

Name CAS No Formula MW
sitaxsentan 184036-34-8 C18H15ClN2O6S2 454.9
Tadalafil 171596-29-5 C22H19N3O4 389.4
Sildenafil (citrate) 171599-83-0 C28H38N6O11S 666.7
Milrinone 78415-72-2 C12H9N3O 211.22
Macitentan 441798-33-0 C19H20Br2N6O4S 588.27
Sildenafil 139755-83-2 C22H30N6O4S 474.58
Sitaxsentan (sodium) 210421-74-2 C18H14ClN2NaO6S2 476.89
Bosentan 147536-97-8 C27H29N5O6S 551.61
Ambrisentan 177036-94-1 C22H22N2O4 378.42
Cleviprex 167221-71-8 C21H23Cl2NO6 456.32
Bosentan (hydrate) 157212-55-0 C27H31N5O7S 569.63
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Route of Synthesis

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References

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More Information

Riociguat

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