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50-14-6 (Vitamin D2)

1

Identification

Vitamin D2 Vitamin D2
Name Vitamin D2
Formula C28H44O
MW 396.64836
CAS No. 50-14-6
EINECS 200-014-9
Smiles C=C1/C(C[[email protected]@H](O)CC1)=C\C=C2[[email protected]@]3([H])[[email protected]@](CCC\2)(C)[[email protected]]([[email protected]](C)/C=C/[[email protected]](C)C(C)C)([H])CC3
Synonyms Ergocalciferol;Calciferol;Ercalciol
InChI InChI=1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1
2

Introduction

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM.

Background Information

Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM. ......by AbMole BioScience
Vitamin D2 has been found to be effective as an antirachitic agent. ......by BOC Sciences
Ergocalciferol, also known as Vitamin D2 and calciferol, is a type of vitamin D found in food and used as a dietary supplement. As a supplement it is used to prevent and treat vitamin D deficiency. This includes vitamin D deficiency due to poor absorption by the intestines or liver disease. It may also be used for low blood calcium due to hypoparathyroidism. It is used by mouth or injection into a muscle. ......by MedKoo Biosciences, Inc.
Vitamin D2 has a strong inhibitory effect against bladder tumor promotion by sodium saccharin and induces cell differentiation in leukemia cells. Vitamin D2 is an inhibitor of DNA Polymerase. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028149

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 20 mg/mL (50.42 mM); Ethanol80 mg/mL (201.68 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Vitamin D2 Albany College of Pharmacy and Health Sciences Vitamin D Deficiency Renal Failure Chronic Requiring Hemodialysis 2011/3/9 2016/1/1 Phase 3 Clinical
Vitamin D2 Winthrop University Hospital Pruritis 2010/4/29 2013/2/1 Phase 3 Clinical
Vitamin D2 New York Presbyterian Hospital Nephrolithiasis Urolithiasis Idiopathic Hypercalciuria Vitamin D Deficiency Disorder of Vitamin D 2011/2/14 2012/9/1 Phase 3 Clinical
Vitamin D2 Dialysis Clinic, Inc. End Stage Renal Disease 2011/7/14 2016/2/15 Phase 3 Clinical
Vitamin D2 Salem Veterans Affairs Medical Center Secondary Hyperparathyroidism Chronic Kidney Disease 2009/8/11 2009/8/1 Phase 3 Clinical
Vitamin D2 - Launched
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Safety Data of Vitamin D2

Hazard Symbols : T+
Risk Statements : R24/25;R26;R48/25
Safety Statements : S28A;S36/37;S45
Transport Information : UN 2811
RTECS : KE1050000
WGKGermany : 3
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 50-14-6

Name CAS No Formula MW

Recommended Compounds in VD/VDR

Name CAS No Formula MW
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 416.64
(24R)-MC 976 112828-09-8 C27H42O3 414.62
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 416.64
Calcitriol Impurities D 103656-40-2 C28H46O3 430.663
Calcifediol (monohydrate) 63283-36-3 C27H44O2 400.64
Cholecalciferol 67-97-0 C27H44O 384.64
(24S)-MC 976 112849-14-6 C27H42O3 414.62
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol C39H68O3Si2 641.1264
VD3-D6 118584-54-6 C27H38D6O 390.67
VD2-D3 1217448-46-8 C28H41D3O 399.67
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 418.68
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 434.68
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 430.62
Cholecalciferol 67-97-0 C27H44O 384.63766
Calcitriol Impurities A 73837-24-8 C27H44O3 416.6365
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 910133-70-9 C27H40O3 412.6047
Paricalcitol 131918-61-1 C27H44O3 416.64
MC 976 129831-99-8 C27H42O3 414.62
24R-Calcipotriol 112827-99-3 C27H40O3 412.6
MC 1046 126860-83-1 C27H38O3 410.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
Bardoxolone 218600-44-3 C31H41NO4 491.66
Bardoxolone (methyl) 218600-53-4 C32H43NO4 505.69
Cinacalcet (hydrochloride) 364782-34-3 C22H23ClF3N 393.87
Aleglitazar (racemate) 475479-24-4 C24H23NO5S 437.5081
Cinacalcet 226256-56-0 C22H22F3N 357.41
Calcitriol 32222-06-3 C27H44O3 416.64
Calcifediol (monohydrate) 63283-36-3 C27H44O2 400.64
Calcifediol 19356-17-3 C27H44O2 400.64
Curcumin 458-37-7 C21H20O6 368.38
Boceprevir 394730-60-0 C27H45N5O5 519.68
Paricalcitol 131918-61-1 C27H44O3 416.64
Heparin 9005-49-6 C26H42N2O37S5 1134.93
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Route of Synthesis

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References

Protocol Reference

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More Information

Vitamin D2

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