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66514-00-9 ((Z)-Olesoxime)

1

Identification

(Z)-Olesoxime (Z)-Olesoxime
Name (Z)-Olesoxime
Formula C27H45NO
MW 399.6523
CAS No. 66514-00-9
EINECS
Smiles C[[email protected]@]12[[email protected]](CC[[email protected]]2([H])[[email protected]](C)CCCC(C)C)([H])[[email protected]@]3([H])[[email protected]]([[email protected]@]4(C(CC3)=C/C(CC4)=N\O)C)([H])CC1
Synonyms
InChI InChI=1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21-/t19-,22+,23-,24+,25+,26+,27-/m1/s1
2

Introduction

Background Information

Olesoxime (TRO19622) is an experimental neuroprotective drug. It is the lead compound of Trophos' cholesterol-oxime compound family of mitochondrial pore modulators. It is a molecule that has a cholesterol-like structure and displays neuroprotective prope ......by BOC Sciences
TRO 19622 is a mitochondrial-targeted neuroprotective compound with mean EC50 value for increasing cell survival is 3.2±0.2 µM. ......by MedChemexpress Co., Ltd.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000022967

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
(Z)-Olesoxime Trophos SA Motor neurone disease 2010/10/31 2011/3/31 Phase 3 Clinical
(Z)-Olesoxime Trophos SA Motor neurone disease 2009/4/30 2011/9/30 Phase 3 Clinical
(Z)-Olesoxime Trophos SA Diabetic neuropathy 2007/5/31 2008/12/31 Phase 2 Clinical
(Z)-Olesoxime Trophos SA Spinal muscular atrophy 2010/11/30 2013/10/31 Phase 2 Clinical
(Z)-Olesoxime Trophos SA Peripheral neuropathy 2009/3/31 2010/9/30 Phase 2 Clinical
(Z)-Olesoxime Trophos SA Non-alcoholic steatohepatitis 2008/4/30 2009/4/30 Phase 2 Clinical
(Z)-Olesoxime - Phase 3
7

Safety Data of (Z)-Olesoxime

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC 5mg/USD72();10mg/USD108() USA
MedChemexpress Co., Ltd. 5mg/USD72();10mg/USD108() USA
Santa Cruz Biotechnology, Inc. 10mg/USD105() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD72();10mg/USD108() China
Sigma-Aldrich, Inc. 5mg/USD105() USA
Tocris Bioscience Inc. 10mg/USD115() USA
World (Jiangsu) Industry Co., Ltd. China
10

Related Products

Other Forms of 66514-00-9

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW
Cebranopadol 863513-91-1 C24H27FN2O 378.48
Rifaximin 80621-81-4 C43H51N3O11 785.88
ADL-5859 850173-95-4 C24H29ClN2O3 428.95
Ranirestat 147254-64-6 C17H11BrFN3O4 420.19
Tapentadol (hydrochloride) 175591-09-0 C14H24ClNO 257.8
Fasudil (Hydrochloride) 105628-07-7 C14H18ClN3O2S 327.83
Dexpramipexole (dihydrochloride) 104632-27-1 C10H19Cl2N3S 284.25
Dexpramipexole 104632-28-2 C10H17N3S 211.33
Lipoic acid 1200-22-2 C8H14O2S2 206.3256
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Route of Synthesis

12

References

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More Information

(Z)-Olesoxime

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