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22033-87-0 (TRO 19622)

1

Identification

TRO 19622 TRO 19622
Name TRO 19622
Formula C27H45NO
MW 399.65
CAS No. 22033-87-0
EINECS
Smiles C[[email protected]]1(CC2)[[email protected]](CC[[email protected]@H]1[[email protected]](C)CCCC(C)C)([H])[[email protected]@](CC3)([H])[[email protected]@]2([H])[[email protected]](CC/4)(C)C3=CC4=N/O
Synonyms Cholest-4-en-3-one oxime; (8S,9S,10R,13R,14S,17R,Z)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one oxime
InChI InChI=1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21-/t19-,22+,23-,24+,25+,26+,27-/m1/s1
2

Introduction

TRO19622, a small cholesterol-like molecule, is a neuroregenerative and neuroprotective compound. IC50 Value: 3.2 ± 0.2 μM(EC50) [1] Target: Others in vitro: TRO19622 maintained survival of 74 ± 10% (n = 8) of the neurons supported by a cocktail of trophic factors (1 ng/ml brain-derived neurotrophic factor, 1 ng/ml glia-derived neurotrophic factor, and 10 ng/ml ciliary neurotrophic factor), defined as 100%.

Background Information

TRO19622, a small cholesterol-like molecule, is a neuroregenerative and neuroprotective compound. IC50 Value: 3.2 ± 0.2 μM(EC50) [1] Target: Others in vitro: TRO19622 maintained survival of 74 ± 10% (n = 8) of the neurons supported by a cocktail of trophic factors (1 ng/ml brain-derived neurotrophic factor, 1 ng/ml glia-derived neurotrophic factor, and 10 ng/ml ciliary neurotrophic factor), defined as 100%. increased overall neurite outgrowth per cell by 54% [1]. Olesoxime prevented neurite shrinkage induced by MTAs in differentiated PC-12 and SK-N-SH neuroblastoma cell lines by up to 90%. Olesoxime also counteracted MTA inhibition of microtubule-dependent mitochondria trafficking. [2]. in vivo: Treatment with TRO19622(3 mg/kg/day) resulted in a significant increase in life span. TRO19622-treated SOD1G93A mice lived 10% longer (138 ± 4 days, n = 7 and 135 ± 3 days, n = 7, for doses of 3 and 30 mg/kg/day, respectively) than did vehicle-treated controls (125 ± 3 days, n = 9) [1]. TRO19622 was also able to reverse tactile allodynia in vincristine-treated rats, a model of chemotherapy-induced neuropathic pain [3]. Olesoxime targets mitochondrial proteins and its effects are consistent with the mitotoxicity hypothesis for paclitaxel-evoked painful peripheral neuropathy. Olesoxime may be useful clinically for both the prevention and treatment of paclitaxel-evoked painful peripheral neuropathy [4]. Phase I clinical trials of olesoxime have been completed successfully. Olesoxime is well tolerated and achieves levels predicted to be clinically effective when administered orally [5]. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000022967

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
TRO 19622 Trophos SA Motor neurone disease 2010/10/31 2011/3/31 Phase 3 Clinical
TRO 19622 Trophos SA Motor neurone disease 2009/4/30 2011/9/30 Phase 3 Clinical
TRO 19622 Trophos SA Diabetic neuropathy 2007/5/31 2008/12/31 Phase 2 Clinical
TRO 19622 Trophos SA Spinal muscular atrophy 2010/11/30 2013/10/31 Phase 2 Clinical
TRO 19622 Trophos SA Peripheral neuropathy 2009/3/31 2010/9/30 Phase 2 Clinical
TRO 19622 Trophos SA Non-alcoholic steatohepatitis 2008/4/30 2009/4/30 Phase 2 Clinical
TRO 19622 - Phase 3
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Safety Data of TRO 19622

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
CHEMSCENE, LLC USA
MedChemexpress Co., Ltd. 5mg/USD60(In stock);10mg/USD90(In stock);50mg/USD360(In stock) USA
Santa Cruz Biotechnology, Inc. 10mg/USD105() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD80(In stock);50mg/USD312(In stock) China
Sigma-Aldrich, Inc. 5mg/USD105() USA
Tocris Bioscience Inc. 10mg/USD115() USA
World (Jiangsu) Industry Co., Ltd. China
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Related Products

Other Forms of 22033-87-0

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
Liothyronine (sodium) 55-06-1 C15H11I3NNaO4 672.96
Afobazole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.87
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Methyl N-ethyl-N-4-(5-nitro-2,1-benzisothiazol-3-yl)azophenyl-alaninate 52239-04-0 C19H19N5O4S 413.45
1,4-bis(Butylamino)anthraquinone 17354-14-2 C22H26N2O2 350.45
CID 797718 370586-05-3 C12H11NO3 217.22

Recommended Compounds in Same Indication

Name CAS No Formula MW
Cebranopadol 863513-91-1 C24H27FN2O 378.48
Rifaximin 80621-81-4 C43H51N3O11 785.88
ADL-5859 850173-95-4 C24H29ClN2O3 428.95
Ranirestat 147254-64-6 C17H11BrFN3O4 420.19
Tapentadol (hydrochloride) 175591-09-0 C14H24ClNO 257.8
Fasudil (Hydrochloride) 105628-07-7 C14H18ClN3O2S 327.83
Dexpramipexole (dihydrochloride) 104632-27-1 C10H19Cl2N3S 284.25
Dexpramipexole 104632-28-2 C10H17N3S 211.33
R-(+)-alpha-Lipoic acid 1200-22-2 C8H14O2S2 206.33
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Route of Synthesis

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References

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More Information

TRO 19622

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