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147254-64-6 (Ranirestat)

1

Identification

Ranirestat Ranirestat
Name Ranirestat
Formula C17H11BrFN3O4
MW 420.19
CAS No. 147254-64-6
EINECS
Smiles O=C(N1CC2=C(F)C=C(Br)C=C2)[[email protected]@](CC3=O)(C(N3)=O)N4C(C1=O)=CC=C4
Synonyms (3R)-2'-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'-1'H-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone; (R)-2'-(4-bromo-2-fluorobenzyl)-1'H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone
InChI InChI=1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1
2

Introduction

Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy by Dainippon Sumitomo Pharma and PharmaKyorin.

Background Information

Ranirestat (AS-3201) is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy. ......by MedChemexpress Co., Ltd.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000019242

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ranirestat Sumitomo Dainippon Pharma Co., Ltd. Diabetic Neuropathy 2005/1/10 Phase 3
Ranirestat Sumitomo Dainippon Pharma Co., Ltd. Mild to Moderate Diabetic Sensorimotor Polyneuropathy. 2009/6/24 Phase 3
Ranirestat - Phase 3 Clinical
7

Safety Data of Ranirestat

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC 5mg/USD350() USA
CHEMSCENE, LLC USA
Clearsynth Labs Limited 10mg/USD500() India
MedChemexpress Co., Ltd. 5mg/USD260(In stock);10mg/USD450(In stock);50mg/USD1200(In stock);100mg/USD2000(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Sigma-Aldrich, Inc. 5mg/USD164() USA
10

Related Products

Other Forms of 147254-64-6

Name CAS No Formula MW

Recommended Compounds in Aldose Reductase

Name CAS No Formula MW
Isoliquiritigenin 961-29-5 C15H12O4 256.25
Tolrestat 82964-04-3 C16H14F3NO3S 357.35
RISARESTAT 79714-31-1 C16H21NO4S 323.41
IMIRESTAT 89391-50-4 C15H8F2N2O2 286.23
Epalrestat 82159-09-9 C15H13NO3S2 319.4
Aldose reductase-IN-1 1355612-71-3 C17H10F3N5O3S 421.35
Alrestatin (sodium) 51876-97-2 C14H8NNaO4 277.21
Alrestatin 51411-04-2 C14H9NO4 255.23

Recommended Compounds in Same Indication

Name CAS No Formula MW
Cebranopadol 863513-91-1 C24H27FN2O 378.48
TRO 19622 22033-87-0 C27H45NO 399.65
ADL-5859 850173-95-4 C24H29ClN2O3 428.95
R-(+)-alpha-Lipoic acid 1200-22-2 C8H14O2S2 206.33
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Route of Synthesis

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References

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More Information

Ranirestat

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