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59643-91-3 (Imexon)

1

Identification

Imexon Imexon
Name Imexon
Formula C4H5N3O
MW 111.1
CAS No. 59643-91-3
EINECS
Smiles O=C1N2CC2C(N)=N1
Synonyms Amplimexon; 4-amino-1,3-diazabicyclo[3.1.0]hex-3-en-2-one
InChI InChI=1S/C4H5N3O/c5-3-2-1-7(2)4(8)6-3/h2H,1H2,(H2,5,6,8)
2

Introduction

Imexon is an iminopyrrolidone aziridine with anti-cancer activity.

Background Information

Imexon is a?cyanoaziridine derivatives with potential anticancer activity.? Imexon belongs to a novel class of promising anticancer agents that induce tumor apoptosis through oxidative stress. Although its mechanism of action is not clearly known, imexon ......by BOC Sciences
Imexon is an iminopyrrolidone aziridine with anti-cancer activity. ......by MedChemexpress Co., Ltd.
Imexon is a cyanoaziridine derivatives with potential anticancer activity. Imexon belongs to a novel class of promising anticancer agents that induce tumor apoptosis through oxidative stress. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Shelf life: >2 years if stored properly Drug formulation: ......by MedKoo Biosciences, Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000019088

Storage condition

Solubility

5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Imexon University of Rochester|University of Arizona Follicular Lymphoma|Small Lymphocytic Lymphoma|Marginal Zone Lymphoma|Lymphoplasmacytic Lymphoma|Diffuse Large B Cell Lymphoma|Mantle Cell Lymphoma|Burkitt's Lymphoma 2011/5/1 Phase 2
Imexon AmpliMed Corporation Pancreatic Neoplasms 2008/4/1 Phase 2
Imexon AmpliMed Corporation Carcinoma, Non-Small-Cell Lung 2010/8/1 Phase 2
Imexon AmpliMed Corporation Neoplasm Metastasis 2005/11/1 Phase 1
Imexon AmpliMed Corporation Non-small Cell Lung Cancer|Breast Cancer|Prostate Cancer 2005/10/1 Phase 1
Imexon AmpliMed Corporation Malignant Melanoma 2005/7/1 Phase 1|Phase 2
Imexon AmpliMed Corporation Multiple Myeloma 2005/10/1 Phase 1|Phase 2
Imexon AmpliMed Corporation Pancreatic Adenocarcinoma 2004/2/1 Phase 1
7

Safety Data of Imexon

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
BOC Sciences
CHEMSCENE, LLC 1mg/USD696();5mg/USD1380() USA
MedChemexpress Co., Ltd. 1mg/USD696();5mg/USD1380() USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1mg/USD696();5mg/USD1380() China
10

Related Products

Other Forms of 59643-91-3

Name CAS No Formula MW

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
3,3',5-Triiodo-L-thyronine (sodium) 55-06-1 C15H11I3NNaO4 672.9553
Fabomotizole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.8721
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Disperse Blue 148 52239-04-0 C19H19N5O4S 413.45026
Solvent Blue 35 17354-14-2 C22H26N2O2 350.454
CID-797718 370586-05-3 C12H11NO3 217.2206

Recommended Compounds in Same Indication

Name CAS No Formula MW
Quisinostat 875320-29-9 C21H26N6O2 394.4702
AT9283 896466-04-9 C19H23N7O2 381.43
MLN9708 1239908-20-3 C20H23BCl2N2O9 517.12
Panobinostat 404950-80-7 C21H23N3O2 349.43
Carfilzomib 868540-17-4 C40H57N5O7 719.91
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 420.48
ARRY-520 885060-09-3 C20H22F2N4O2S 420.48
Thalidomide 50-35-1 C13H10N2O4 258.23
Delanzomib 847499-27-8 C21H28BN3O5 413.28
RO4929097 847925-91-1 C22H20F5N3O3 469.4
Erastin 571203-78-6 C30H31ClN4O4 547.04
AT7519 844442-38-2 C16H17Cl2N5O2 382.24
Danusertib 827318-97-8 C26H30N6O3 474.55
Masitinib 790299-79-5 C28H30N6OS 498.64
Pomalidomide 19171-19-8 C13H11N3O4 273.24
Lenalidomide 191732-72-6 C13H13N3O3 259.26
PHA-680632 398493-79-3 C28H35N7O2 501.62
INK-128 1224844-38-5
Lenalidomide (hydrochloride) 1243329-97-6 C13H14ClN3O3 295.72
PX-12 141400-58-0 C7H12N2S2 188.31
11

Route of Synthesis

12

References

Protocol Reference

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More Information

Imexon

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