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49562-28-9 (Fenofibrate)

1

Identification

Fenofibrate Fenofibrate
Name Fenofibrate
Formula C20H21ClO4
MW 360.83
CAS No. 49562-28-9
EINECS 256-376-3
Smiles O=C(C1=CC=C(Cl)C=C1)C2=CC=C(OC(C)(C)C(OC(C)C)=O)C=C2
Synonyms 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester; Proctofene; Sedufen; isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
InChI InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
2

Introduction

Fenofibrate is PPARα agonist with EC50 of 18 μM and 30 μM for mouse and human PPARα, respectively.

Background Information

Fenofibrate (Tricor, Trilipix) is a compound of the fibrate class and fibric acid derivative.It is used alone or along with statins in the treatment of hypercholesterolemia and hypertriglyceridemia. ......by BOC Sciences
Fenofibrate is a relatively potent inhibitor of CYP2C19 (IC50=0.2 μM) and CYP2B6 (IC50=0.7 μM). Fenofibrate is also a well-known PPARα agonist (EC50=30 μM). ......by MedChemexpress Co., Ltd.
Fenofibrate (Tricor, Trilipix) is a compound of the fibrate class and fibric acid derivative. ......by Selleck Chemicals LLC
Fenofibrate is a Peroxisome Proliferator Receptor alpha Agonist. The mechanism of action of fenofibrate is as a Peroxisome Proliferator-activated Receptor alpha Agonist. The chemical classification of fenofibrate is PPAR alpha. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000018142

Storage condition

Solubility

DMSO 100 mM Ethanol 100 mM by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 72 mg/mL (199.53 mM); Ethanol46 mg/mL (127.48 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Fenofibrate Keogh Institute for Medical Research 2005/8/31 2009/10/31 Phase 4 Clinical
Fenofibrate Daiichi Sankyo Co Ltd Familial hypercholesterolemia 2003/2/28 2004/3/31 Phase 4 Clinical
Fenofibrate Novartis AG Lipid metabolism disorder 2006/8/31 2007/3/31 Phase 4 Clinical
Fenofibrate Solvay SA Hyperlipidemia 2005/1/31 Phase 3 Clinical
Fenofibrate Chong Kun Dang Pharmaceutical Corp Hypercholesterolemia 2013/12/31 2015/2/28 Phase 3 Clinical
Fenofibrate - Launched
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Safety Data of Fenofibrate

Hazard Symbols : Xn
Risk Statements : R22
Safety Statements : S36
RTECS : UA2453400
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Abblis Chemicals LLC 200mg/USD50(In Stock) USA
Abcam 5g/USD39() USA
BOC Sciences
CHEMSCENE, LLC 5g/USD60();10g/USD72() USA
Carbosynth Limited 5g/USD54()
Cayman Chemical Company 1g/USD9() USA
D.K. Pharma Chem Pvt. Ltd. India
Hangzhou Luna Chemicals Co., Ltd. China
Jiangsu Nhwa Pharmaceutical Co., Ltd. China
Matrix Scientific 5g/USD57() USA
MedChemexpress Co., Ltd. 5g/USD60();10g/USD72() USA
Nexchem Pharmaceutical Co., Ltd. China
Santa Cruz Biotechnology, Inc. 5g/USD34() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);10mM(in 1mL DMSO)/USD163(in 1mL DMSO) USA
Shanghai Ecust Biomedicine Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 5g/USD60();10g/USD72() China
Sigma-Aldrich, Inc. 5g/USD43() USA
Spectrum Chemical Mfg. Corp. 5g/USD44() USA
Target Molecule Corp. 2mg/USD20();10mg/USD42();50mg/USD78();200mg/USD122() USA
Tocris Bioscience Inc. 50mg/USD45() USA
Tokyo Chemical Industry Co., Ltd. 5g/USD35() Japan
Zhejiang Excel Pharmaceutical Co., Ltd. China
Zhejiang Ideal Biotech Co., Ltd. China
Zhejiang Wonderful Pharma & Chem Co., Ltd. China
10

Related Products

Other Forms of 49562-28-9

Name CAS No Formula MW

Recommended Compounds in PPAR Autophagy Cytochrome P450

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Procyanidin B2 29106-49-8 C30H26O12 578.52
Eupatilin 22368-21-4 C18H16O7 344.32
Fenofibric acid 42017-89-0 C17H15ClO4 318.75
Ciprofibrate 52214-84-3 C13H14Cl2O3 289.15
Bezafibrate 41859-67-0 C19H20ClNO4 361.82
Clofibrate 637-07-0 C12H15ClO3 242.7
Gemfibrozil 25812-30-0 C15H22O3 250.33
Pioglitazone 111025-46-8 C19H20N2O3S 356.44
GW0742 317318-84-6 C21H17F4NO3S2 471.4882
CDDO-Im 443104-02-7 C34H43N3O3 541.72
FH535 108409-83-2 C13H10Cl2N2O4S 361.2
Inolitazone (dihydrochloride) 223132-38-5 C27H28Cl2N4O4S 575.51
GW1929 196808-24-9 C30H29N3O4 495.57
Magnolol 528-43-8 C18H18O2 266.33
5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one 67604-48-2 C15H12O5 272.256
GSK3787 188591-46-0 C15H12ClF3N2O3S 392.78
Daidzein 486-66-8 C15H10O4 254.24
GW9662 22978-25-2 C13H9ClN2O3 276.68
Rosiglitazone 122320-73-4 C18H19N3O3S 357.43

Recommended Compounds in Same Indication

Name CAS No Formula MW
Anacetrapib 875446-37-0 C30H25F10NO3 637.51
ETC-1002 738606-46-7 C19H36O5 344.49
Choline Fenofibrate 856676-23-8 C22H28ClNO5 421.91
Torcetrapib 262352-17-0 C26H25F9N2O4 600.4733
Laropiprant 571170-77-9 C21H19ClFNO4S 435.9
Rimonabant 168273-06-1 C22H21Cl3N4O 463.79
WAY-362450 629664-81-9 C25H24F2N2O3 438.47
Ezetimibe 163222-33-1 C24H21F2NO3 409.43
Dalcetrapib 211513-37-0 C23H35NO2S 389.59
Evacetrapib 1186486-62-3 C31H36F6N6O2 638.65
Rimonabant (Hydrochloride) 158681-13-1 C22H22Cl4N4O 500.25
Fluvastatin 93957-54-1 C24H26FNO4 411.47
BRADYKININ 58-82-2 C50H73N15O11 1060.21
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Route of Synthesis

12

References

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More Information

Fenofibrate

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