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49562-28-9 (Fenofibrate)

1

Identification

Fenofibrate Fenofibrate
Name Fenofibrate
Formula C20H21ClO4
MW 360.83
CAS No. 49562-28-9
EINECS 256-376-3
Smiles O=C(C1=CC=C(Cl)C=C1)C2=CC=C(OC(C)(C)C(OC(C)C)=O)C=C2
Synonyms 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester; Proctofene; Sedufen; isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate
InChI InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
2

Introduction

Fenofibrate is PPARα agonist with EC50 of 18 μM and 30 μM for mouse and human PPARα, respectively.

Background Information

Fenofibrate is PPARα agonist with EC50 of 18 μM and 30 μM for mouse and human PPARα, respectively. IC50 Value: 18 μM(EC50 for mouse PPARα); 30 μM(EC50 for human PPARα) Target: PPARα Fenofibrate (Tricor, Trilipix) is a compound of the fibrate class and fibric acid derivative. Fenofibrate (Tricor, Trilipix) is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Like other fibrates, fenofibrate (Tricor, Trilipix) reduces both low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high-density lipoprotein (HDL) levels and reducing tryglycerides level. Fenofibrate (Tricor, Trilipix) also appears to have a beneficial effect on the insulin resistance featured by the metabolic syndrome. Fenofibrate (Tricor, Trilipix) is used alone or in conjunction with statins in the treatment of hypercholesterolemia and hypertriglyceridemia. ......by MedChemexpress Co., Ltd.
Fenofibrate (Tricor, Trilipix) is a compound of the fibrate class and fibric acid derivative. ......by Selleck Chemicals LLC
Fenofibrate is a Peroxisome Proliferator Receptor alpha Agonist. The mechanism of action of fenofibrate is as a Peroxisome Proliferator-activated Receptor alpha Agonist. The chemical classification of fenofibrate is PPAR alpha. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000018142

Storage condition

Solubility

DMSO 100 mM Ethanol 100 mM by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 72 mg/mL (199.53 mM); Ethanol46 mg/mL (127.48 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Fenofibrate Keogh Institute for Medical Research 2005/8/31 2009/10/31 Phase 4 Clinical
Fenofibrate Daiichi Sankyo Co Ltd Familial hypercholesterolemia 2003/2/28 2004/3/31 Phase 4 Clinical
Fenofibrate Novartis AG Lipid metabolism disorder 2006/8/31 2007/3/31 Phase 4 Clinical
Fenofibrate Solvay SA Hyperlipidemia 2005/1/31 Phase 3 Clinical
Fenofibrate Chong Kun Dang Pharmaceutical Corp Hypercholesterolemia 2013/12/31 2015/2/28 Phase 3 Clinical
Fenofibrate - Launched
7

Safety Data of Fenofibrate

Hazard Symbols : Xn
Risk Statements : R22
Safety Statements : S36
RTECS : UA2453400
WGKGermany : 3
8

Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Abblis Chemicals LLC 200mg/USD50(In Stock) USA
Abcam 5g/USD39() USA
CHEMSCENE, LLC USA
Carbosynth Limited 5g/USD54()
Cayman Chemical Company 1g/USD9() USA
D.K. Pharma Chem Pvt. Ltd. India
Hangzhou Luna Chemicals Co., Ltd. China
Jiangsu Nhwa Pharmaceutical Co., Ltd. China
Matrix Scientific 5g/USD57() USA
MedChemexpress Co., Ltd. 5g/USD50(In stock);10g/USD60(In stock) USA
Nexchem Pharmaceutical Co., Ltd. China
Santa Cruz Biotechnology, Inc. 5g/USD34() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);10mM(in 1mL DMSO)/USD163(in 1mL DMSO) USA
Shanghai Ecust Biomedicine Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD44(In stock);10mg/USD66(In stock) China
Sigma-Aldrich, Inc. 5g/USD43() USA
Spectrum Chemical Mfg. Corp. 5g/USD44() USA
Target Molecule Corp. 2mg/USD20();10mg/USD42();50mg/USD78();200mg/USD122() USA
Tocris Bioscience Inc. 50mg/USD45() USA
Tokyo Chemical Industry Co., Ltd. 5g/USD35() Japan
Zhejiang Excel Pharmaceutical Co., Ltd. China
Zhejiang Ideal Biotech Co., Ltd. China
Zhejiang Wonderful Pharma & Chem Co., Ltd. China
10

Related Products

Other Forms of 49562-28-9

Name CAS No Formula MW

Recommended Compounds in PPAR Autophagy Cytochrome P450

Name CAS No Formula MW
(20S)-Protopanaxatriol 34080-08-5 C30H52O4 476.73
Procyanidin B2 29106-49-8 C30H26O12 578.52
Eupatilin 22368-21-4 C18H16O7 344.32
Fenofibric acid 42017-89-0 C17H15ClO4 318.75
Ciprofibrate 52214-84-3 C13H14Cl2O3 289.15
Bezafibrate 41859-67-0 C19H20ClNO4 361.82
Clofibrate 637-07-0 C12H15ClO3 242.7
Gemfibrozil 25812-30-0 C15H22O3 250.33
Pioglitazone 111025-46-8 C19H20N2O3S 356.44
Acetic acid, 2-[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]- 317318-84-6 C21H17F4NO3S2 471.49
CDDO-Im 443104-02-7 C34H43N3O3 541.72
FH535 108409-83-2 C13H10Cl2N2O4S 361.2
Inolitazone (dihydrochloride) 223132-38-5 C27H28Cl2N4O4S 575.51
GW1929 196808-24-9 C30H29N3O4 495.57
Magnolol 528-43-8 C18H18O2 266.33
Naringenin 480-41-1 C15H12O5 272.25
GSK3787 188591-46-0 C15H12ClF3N2O3S 392.78
Daidzein 486-66-8 C15H10O4 254.24
GW9662 22978-25-2 C13H9ClN2O3 276.68
Rosiglitazone 122320-73-4 C18H19N3O3S 357.43

Recommended Compounds in Same Indication

Name CAS No Formula MW
Anacetrapib 875446-37-0 C30H25F10NO3 637.51
ETC-1002 738606-46-7 C19H36O5 344.49
Choline Fenofibrate 856676-23-8 C22H28ClNO5 421.91
CP 529414 262352-17-0 C26H25F9N2O4 600.47
Laropiprant 571170-77-9 C21H19ClFNO4S 435.9
Rimonabant 168273-06-1 C22H21Cl3N4O 463.79
WAY-362450 629664-81-9 C25H24F2N2O3 438.47
Ezetimibe 163222-33-1 C24H21F2NO3 409.43
Dalcetrapib 211513-37-0 C23H35NO2S 389.59
Evacetrapib 1186486-62-3 C31H36F6N6O2 638.65
Rimonabant (Hydrochloride) 158681-13-1 C22H22Cl4N4O 500.25
Fluvastatin 93957-54-1 C24H26FNO4 411.47
BRADYKININ 58-82-2 C50H73N15O11 1060.21
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Route of Synthesis

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References

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More Information

Fenofibrate

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