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1256963-02-6 (CDK4-IN-1)

1

Identification

CDK4-IN-1 CDK4-IN-1
Name CDK4-IN-1
Formula C22H29ClN8
MW 440.97
CAS No. 1256963-02-6
EINECS
Smiles CN(C1CCN(C2=CN=C(NC3=NC=CC(C4=C(Cl)NN=C4C(C)C)=N3)C=C2)CC1)C
Synonyms 4-(5-chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine
InChI InChI=1S/C22H29ClN8/c1-14(2)20-19(21(23)29-28-20)17-7-10-24-22(26-17)27-18-6-5-16(13-25-18)31-11-8-15(9-12-31)30(3)4/h5-7,10,13-15H,8-9,11-12H2,1-4H3,(H,28,29)(H,24,25,26,27)
2

Introduction

CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. IC50 Value: 10 nM (CDK4/Cyclin D1) [1] Target: CDK4 CDK4/6 inhibitor imposed a G1 block on cells at 0.37μM in the CDK4 Cellular Assays.

Background Information

CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer. ......by BOC Sciences
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. IC50 Value: 10 nM (CDK4/Cyclin D1) [1] Target: CDK4 CDK4/6 inhibitor imposed a G1 block on cells at 0.37μM in the CDK4 Cellular Assays. CDK4/6 inhibitor exhibited the most sustained G1 arrest among five compounds and were tested further against a selection of serine-threonine and tyrosine kinases and proved to be selective for CDK4/6 over 35 other kinases [1]. ......by MedChemexpress Co., Ltd.
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000015381

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
CDK4-IN-1 - Not Found
CDK4-IN-1 - No Development Reported
7

Safety Data of CDK4-IN-1

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC 10mg/USD361(Ship Within 10-14 Days) USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC USA
Lancrix Chemicals. 10mg/USD318() China
MedChemexpress Co., Ltd. 5mg/USD250(Get quote);10mg/USD380(Get quote);25mg/USD550(Get quote);50mg/USD900(Get quote);100mg/USD1400(Get quote) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD250();10mg/USD380() China
Target Molecule Corp. 5mg/USD137();10mg/USD222();25mg/USD394();50mg/USD690();100mg/USD998() USA
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Related Products

Other Forms of 1256963-02-6

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9
NU6102 444722-95-6 C18H22N6O3S 402.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

CDK4-IN-1

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