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484-20-8 (Bergapten)

1

Identification

Bergapten Bergapten
Name Bergapten
Formula C12H8O4
MW 216.19
CAS No. 484-20-8
EINECS 207-604-5
Smiles COC1=C(C=CC2=O)C(O2)=CC3=C1C=CO3
Synonyms 5-Methoxypsoralen; 4-Methoxy-7H-furo[3,2-g]chromen-7-one; 4-methoxy-7H-furo[3,2-g]chromen-7-one
InChI InChI=1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3
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Introduction

5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo; inhibit proliferation in the human hepatocellular carcinoma cell line. IC50 value: Target: anti cancer in vitro: 5-MOP increased the activity of NATand also increased the further metabolism of AAF at 24 h in the rat stomach.

Background Information

Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. ......by BOC Sciences
Bergapten is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. Bergapten is inhibitory towards mouse and human CYP isoforms. ......by MedChemexpress Co., Ltd.
Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013521

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease Autophagy
Target Autophagy Cytochrome P450
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Bergapten - Phase 3 Clinical
Bergapten - Phase 3
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Safety Data of Bergapten

´╗┐Hazard Symbols : Xi
´╗┐Risk Statements : R43
Safety Statements : S36/37
RTECS : LV1300000
WGKGermany : 2
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
Andard-Mount Company Limited UNITED KINGDOM
BOC Sciences
Baoji Herbest Bio-Tech Co., Ltd. China
CHEMSCENE, LLC 1g/USD144();5g/USD576() USA
MedChemexpress Co., Ltd. 1g/USD144();5g/USD576() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD144();5g/USD576() China
Target Molecule Corp. 10mg/USD89();25mg/USD146();50mg/USD209() USA
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Related Products

Other Forms of 484-20-8

Name CAS No Formula MW

Recommended Compounds in Autophagy Cytochrome P450

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Berberine (chloride) 633-65-8 C20H18ClNO4 371.8142
DMH-1 1206711-16-1 C24H20N4O 380.44
CB-839 1439399-58-2 C26H24F3N7O3S 571.57
H-89 (dihydrochloride) 130964-39-5 C20H22BrCl2N3O2S 519.2826
Shikonin 517-89-5 C16H16O5 288.3
H 89 127243-85-0 C20H20BrN3O2S 446.36
Eupatilin 22368-21-4 C18H16O7 344.32
Isoalantolactone 470-17-7 C15H20O2 232.32
Scutellarein 529-53-3 C15H10O6 286.24
Leonurine 24697-74-3 C14H21N3O5 311.33
Berbamine (dihydrochloride) 6078-17-7 C37H42Cl2N2O6 681.6452
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 306.37
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
Schizandrin A 61281-38-7 C22H28O6 388.45
Schisandrol B 58546-54-6 C23H28O7 416.46
Schisandrol A 7432-28-2 C24H32O7 432.51
Icaritin 118525-40-9 C21H20O6 368.3799
Bicyclol 118159-48-1 C19H18O9 390.34
Azithromycin 83905-01-5 C38H72N2O12 748.9845

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Bergapten

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