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81103-11-9 (Clarithromycin)

1

Identification

Clarithromycin Clarithromycin
Name Clarithromycin
Formula C38H69NO13
MW 747.95
CAS No. 81103-11-9
EINECS
Smiles C[[email protected]@](OC)(C[[email protected]](C([[email protected]@H]1C)=O)C)[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](C(O[[email protected]](CC)[[email protected]@](C)(O)[[email protected]@H]1O)=O)C)O[[email protected]@](O[[email protected]@H](C)[[email protected]@H]2O)([H])C[[email protected]@]2(C)OC)C)O[[email protected]@](O[[email protected]](C)C[[email protected]@H]3N(C)C)([H])[[email protected]@H]3O
Synonyms Biaxin;Biaxin XL;Clarosip;Klaricid; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione
InChI InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
2

Introduction

Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor. Target: Antibacterial; CYP3A4 Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections.

Background Information

Clarithromycin, a CYP3A4 inhibitor, is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia, skin and skin structure infections. It prevents bacteria from g ......by BOC Sciences
Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor, used to treat a number of bacterial infections. ......by Selleck Chemicals LLC
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit protein synthesis in bacteria by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012619

Storage condition

Solubility

DMSO 5 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 25 mg/mL warming (33.42 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease Autophagy Anti-infection
Target Bacterial Autophagy Cytochrome P450
Research Area Infection
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Clarithromycin - Launched
7

Safety Data of Clarithromycin

Hazard Symbols : Xn,Xi
Risk Statements : 22-36/37/38
Safety Statements : 26-36
HS Code : 29419000
RTECS : KF4997000
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
BOC Sciences
CHEMSCENE, LLC 100mg/USD60();200mg/USD96() USA
Carbosynth Limited 10g/USD40()
Glentham Life Sciences
Liaoyang Zhongnuo Chemical & Industry Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60();200mg/USD96() USA
Santa Cruz Biotechnology, Inc. 100mg/USD69() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shandong Fangming Pharmaceutical Group Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();200mg/USD96() China
Sigma-Aldrich, Inc. 100mg/USD71() USA
Target Molecule Corp. 2mg/USD20();10mg/USD65();50mg/USD237();200mg/USD368() USA
Tokyo Chemical Industry Co., Ltd. 1g/USD51() Japan
Zhejiang Botai Chemical Co., Ltd. China
Zhejiang Chemline industries Co., Ltd. China
Zhejiang Ouhua Chemical Imp. & Exp. Co., Ltd. China
10

Related Products

Other Forms of 81103-11-9

Name CAS No Formula MW

Recommended Compounds in Bacterial Autophagy Cytochrome P450

Name CAS No Formula MW
Fidaxomicin 873857-62-6 C52H74Cl2O18 1058.04
AVX 13616 900814-48-4 C50H73Cl2N7O7 955.06
Bedaquiline (fumarate) 845533-86-0 C36H35BrN2O6 671.58
Mafenide (Acetate) 13009-99-9 C9H14N2O4S 246.28
Cefozopran 113359-04-9 C19H17N9O5S2 515.53
Azithromycin 83905-01-5 C38H72N2O12 748.9845
Pazufloxacin 127045-41-4 C16H15FN2O4 318.3
Pazufloxacin (mesylate) 163680-77-1 C17H19FN2O7S 414.4054
Capreomycin (sulfate) 1405-37-4 C24H44N14O12S 752.76
Bleomycin (sulfate) 9041-93-4 C110H168N34O46S7 2927.17
G-418 (disulfate) 108321-42-2 C20H44N4O18S2 692.71
Demeclocycline (hydrochloride) 64-73-3 C21H22Cl2N2O8 501.31
Apramycin 37321-09-8 C21H41N5O11 539.58
Ceftriaxone 73384-59-5 C18H18N8O7S3 554.58
Ceftibuten 97519-39-6 C15H14N4O6S2 410.42
Dapsone 80-08-0 C12H12N2O2S 248.3
Vancomycin 1404-90-6 C66H76Cl3N9O24 1485.72
Lomefloxacin 98079-51-7 C17H19F2N3O3 351.35
Dirithromycin 62013-04-1 C42H78N2O14 835.07
Cefepime (Dihydrochloride Monohydrate) 123171-59-5 C19H28Cl2N6O6S2 571.5

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Clarithromycin

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