861119-08-6 (A 844606)

Identification

Name	A 844606
Formula	C20H20N2O2
MW	320.39
CAS No.	861119-08-6
EINECS

Smiles	O=C1C2=CC(N3C[[email protected]]4CN(C[[email protected]@H]4C3)C)=CC=C2OC5=CC=CC=C15
Synonyms	2-((3aR,6aR)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one
InChI	InChI=1S/C20H20N2O2/c1-21-9-13-11-22(12-14(13)10-21)15-6-7-19-17(8-15)20(23)16-4-2-3-5-18(16)24-19/h2-8,13-14H,9-12H2,1H3/t13-,14-/m1/s1

Introduction

Background Information

Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC₅₀ values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells. ......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Physical and Chemical Properties

Appearance:

EBNumber:EB000123836

Storage condition

Store at -20°C

by Tocris Bioscience Inc.

Solubility

Soluble to 5 mM in ethanol with gentle warming

by Tocris Bioscience Inc.

Mechanism and Indication

Signaling Pathways

Target

Research Area

Indications

Clinical Information

Product Name	Sponsor & Collaborators	Indications	Start Date	End Date	Phase

Safety Data of A 844606

Spectral Information

Suppliers List

Company	Price and Availability	Country/Region
Tocris Bioscience Inc.		USA

Related Products

Other Forms of 861119-08-6

Name	CAS No	Formula	MW

Recommended Compounds in

Name	CAS No	Formula	MW

Recommended Compounds in Same Indication

Name	CAS No	Formula	MW

Route of Synthesis

References

Protocol Reference

Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054. PMID: 18157163.

......by Tocris Bioscience Inc.

More Information

A 844606