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861119-08-6 (A 844606)

1

Identification

A 844606 A 844606
Name A 844606
Formula C20H20N2O2
MW 320.39
CAS No. 861119-08-6
EINECS
Smiles O=C1C2=CC(N3C[[email protected]]4CN(C[[email protected]@H]4C3)C)=CC=C2OC5=CC=CC=C15
Synonyms 2-((3aR,6aR)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one
InChI InChI=1S/C20H20N2O2/c1-21-9-13-11-22(12-14(13)10-21)15-6-7-19-17(8-15)20(23)16-4-2-3-5-18(16)24-19/h2-8,13-14H,9-12H2,1H3/t13-,14-/m1/s1
2

Introduction

Background Information

Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000123836

Storage condition

Store at -20°C by Tocris Bioscience Inc.

Solubility

Soluble to 5 mM in ethanol with gentle warming by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of A 844606

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 861119-08-6

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

Protocol Reference

Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054. PMID: 18157163.

......by Tocris Bioscience Inc.
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More Information

A 844606

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