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869802-58-4 (A 841720)

1

Identification

A 841720 A 841720
Name A 841720
Formula C17H21N5OS
MW 343.45
CAS No. 869802-58-4
EINECS
Smiles O=C1C2=C(N=CN1N3CCCCCC3)C4=C(N(C)C)C=CN=C4S2
Synonyms 3-(azepan-1-yl)-9-(dimethylamino)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
InChI InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3
2

Introduction

Background Information

Potent, non-competitive mGlu1 receptor antagonist that displays 34-fold selectivity over mGlu5 (IC50 values are 10 and 342 nM respectively). Displays no significant activity at a range of other GPCRs, ion channels and transporters. Exhibits analgesic effects; decreases mechanical allodynia in models of neuropathic pain. Also impairs cognitive function. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000123679

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

Soluble to 50 mM in DMSO and to 50 mM in ethanol by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways
Target
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of A 841720

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Shanghai Haoyuan Chemexpress Co., Ltd. China
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 869802-58-4

Name CAS No Formula MW

Recommended Compounds in

Name CAS No Formula MW

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

Protocol Reference

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More Information

A 841720

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