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222638-67-7 (S-(2-Boronoethyl)-L-cysteine (hydrochloride))

1

Identification

S-(2-Boronoethyl)-L-cysteine (hydrochloride) S-(2-Boronoethyl)-L-cysteine (hydrochloride)
Name S-(2-Boronoethyl)-L-cysteine (hydrochloride)
Formula C5H13BClNO4S
MW 229.49
CAS No. 222638-67-7
EINECS
Smiles N[[email protected]@H](CSCCB(O)O)C(O)=O.[H]Cl
Synonyms BEC hydrochloride; (R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride
InChI InChI=1S/C5H12BNO4S.ClH/c7-4(5(8)9)3-12-2-1-6(10)11;/h4,10-11H,1-3,7H2,(H,8,9);1H/t4-;/m0./s1
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Introduction

Kidney Int. 2013 Dec;84(6):1189-97.Mol Cell Biochem. 2015 Nov 25.

Background Information

BEC HCl is an Arginase II inhibitor(Ki=0.31μM).In vitro,BEC HCl enhances NO-dependent smooth muscle relaxation by binding to arginase as a transition state analogue.In vivo,BEC HCl enhances peribronchiolar and perivascular inflammation in mice. ......by BOC Sciences
BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5). target: Arginase II [1]; In vitro: BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4] ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000068197

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.

Solubility

H<sub>2</sub>O: ≥ 35 mg/mL by CHEMSCENE, LLC
45 mg/mL in H2O; 45 mg/mL in DMSO. by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
S-(2-Boronoethyl)-L-cysteine (hydrochloride) - Launched
S-(2-Boronoethyl)-L-cysteine (hydrochloride) - No Development Reported
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Safety Data of S-(2-Boronoethyl)-L-cysteine (hydrochloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC USA
MedChemexpress Co., Ltd. 1mg/USD150(In stock);5mg/USD350(In stock);10mg/USD500(In stock);50mg/USD1500(In stock);100mg/USD2100(In stock) USA
Qventas, Inc. USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
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Related Products

Other Forms of 222638-67-7

Name CAS No Formula MW
S-(2-Boronoethyl)-L-cysteine 63107-40-4 C5H12BNO4S 193.03

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
Liothyronine (sodium) 55-06-1 C15H11I3NNaO4 672.96
Afobazole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.87
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Methyl N-ethyl-N-4-(5-nitro-2,1-benzisothiazol-3-yl)azophenyl-alaninate 52239-04-0 C19H19N5O4S 413.45
1,4-bis(Butylamino)anthraquinone 17354-14-2 C22H26N2O2 350.45
CID 797718 370586-05-3 C12H11NO3 217.22

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

S-(2-Boronoethyl)-L-cysteine (hydrochloride)

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