• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

899507-36-9 (A 438079)

1

Identification

A 438079 A 438079
Name A 438079
Formula C13H9Cl2N5
MW 306.15
CAS No. 899507-36-9
EINECS
Smiles ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1
Synonyms 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine
InChI InChI=1S/C13H9Cl2N5/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9/h1-7H,8H2
2

Introduction

A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). IC50 Value: The P2X7 purinergic receptor is a ligand-gated cation channel expressed on leukocytes including microglia[1].

Background Information

A 438079 hydrochloride is a competitive P2X7 receptor antagonist with pIC50 value of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. It protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, but n ......by BOC Sciences
A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). IC50 Value: The P2X7 purinergic receptor is a ligand-gated cation channel expressed on leukocytes including microglia[1]. The P2X7 receptor participates in purinergic signaling, which may promote the progression of ADPKD[3]. in vitro:. To determine the effect of inhibiting P2X7Rs on hippocampal inflammatory cytokine production, the expression levels of three cytokines, IL-1?, TNF-α and IL-6 were tested by RT-PCR at +3D. As expected, transient global cerebral I/R significantly increased mRNA expression of IL-1?, TNF-α and IL-6 in the hippocampus. Administration of BBG 10 μg, OxATP 1 μg or A-438079 3 μg markedly attenuated the I/R-induced overexpression of IL-1?, TNF-α and IL-6[2]. in vivo: Neuronal survival in A-438079 treated animals was similar to survival rates in those treated with BBG and A-438079 0.3 μg and A-438079 3 μg treated animals, with significantly more surviving hippocampal CA1 neurons when compared to the A-438079 0.03 μg and saline groups. Rats from the A-438079 3 μg group had higher neuron survival rates than those from the OxATP 1 μg group (87.8 ± 6.0% versus70.4 ± 8.6%). The neuron survival rate in the BBG 10 μg and A-438079 3 μg group did not differ from each other at +7D. The survival rates of rats during the seven days after I/R injury was significantly reduced in the BBG 10 μg (95.2%), OxATP 1 μg(92.0%) and A-438079 3 μg (93.8%) treated groups when compared to the saline group(72.4%). No significant difference was observed among the BBG 10 μg, OxATP 1 μg and A-438079 3 μg group[2]. ......by MedChemexpress Co., Ltd.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000017753

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target P2X Receptor
Research Area Neurological Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A 438079 - Not Found
A 438079 - No Development Reported
7

Safety Data of A 438079

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC 10mg/USD121() USA
BOC Sciences
CHEMSCENE, LLC USA
MedChemexpress Co., Ltd. 10mg/USD120(In stock);50mg/USD466(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD120(In stock);50mg/USD466(In stock) China
10

Related Products

Other Forms of 899507-36-9

Name CAS No Formula MW
A 438079 (hydrochloride) 899431-18-6 C13H10Cl3N5 342.61

Recommended Compounds in P2X Receptor

Name CAS No Formula MW
ATP (disodium salt) 987-65-5 C10H14N5Na2O13P3 551.14
Lappaconitine 32854-75-4 C32H44N2O8 584.7
A 839977 870061-27-1 C19H14Cl2N6O 413.26
A-317491 475205-49-3 C33H27NO8 565.57
A 438079 (hydrochloride) 899431-18-6 C13H10Cl3N5 342.61
GW791343 (trihydrochloride) 309712-55-8 C20H27Cl3F2N4O 483.81
GW791343 (dihydrochloride) 1019779-04-4 C20H26Cl2F2N4O 447.35
AF 353 865305-30-2 C14H17IN4O2 400.21
KN-62 127191-97-3 C38H35N5O6S2 721.84
A-740003 861393-28-4 C26H30N6O3 474.55
A-804598 1125758-85-1 C19H20N2O3 324.37
PSB-12062 55476-47-6 C22H22ClN5O2 423.9
AZD9056 (hydrochloride) 345303-91-5 C24H36Cl2N2O2 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

A 438079

Tags: buy 899507-36-9 IC50 | 899507-36-9 price | 899507-36-9 cost | 899507-36-9 solubility | 899507-36-9 purchase | 899507-36-9 manufacturer | 899507-36-9 research buy | 899507-36-9 order | 899507-36-9 MSDS | 899507-36-9 chemical structure | 899507-36-9 Storage condition | 899507-36-9 molecular weight | 899507-36-9 mw | 899507-36-9 datasheet | 899507-36-9 supplier | 899507-36-9 cell line | 899507-36-9 NMR | 899507-36-9 MS | 899507-36-9 IR | 899507-36-9 solubility | 899507-36-9 Safe information | 899507-36-9 Qc and Spectral Information | 899507-36-9 Clinical Information | 899507-36-9 Clinical Trial | 899507-36-9 Route of Synthesis | 899507-36-9 storage condition | 899507-36-9 diseases and conditions | 899507-36-9 flash point | 899507-36-9 boiling point | 899507-36-9 melting point | 899507-36-9 storage condition | 899507-36-9 brand