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|Name||A 438079 (hydrochloride)|
A 438079 Hcl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). IC50 Value: The P2X7 purinergic receptor is a ligand-gated cation channel expressed on leukocytes including microglia.
|A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. ......by BOC Sciences|
|A 438079 Hcl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). IC50 Value: The P2X7 purinergic receptor is a ligand-gated cation channel expressed on leukocytes including microglia. The P2X7 receptor participates in purinergic signaling, which may promote the progression of ADPKD. in vitro:. To determine the effect of inhibiting P2X7Rs on hippocampal inflammatory cytokine production, the expression levels of three cytokines, IL-1?, TNF-α and IL-6 were tested by RT-PCR at +3D. As expected, transient global cerebral I/R significantly increased mRNA expression of IL-1?, TNF-α and IL-6 in the hippocampus. Administration of BBG 10 μg, OxATP 1 μg or A-438079 3 μg markedly attenuated the I/R-induced overexpression of IL-1?, TNF-α and IL-6. in vivo: Neuronal survival in A-438079 treated animals was similar to survival rates in those treated with BBG and A-438079 0.3 μg and A-438079 3 μg treated animals, with significantly more surviving hippocampal CA1 neurons when compared to the A-438079 0.03 μg and saline groups. Rats from the A-438079 3 μg group had higher neuron survival rates than those from the OxATP 1 μg group (87.8 ± 6.0% versus70.4 ± 8.6%). The neuron survival rate in the BBG 10 μg and A-438079 3 μg group did not differ from each other at +7D. The survival rates of rats during the seven days after I/R injury was significantly reduced in the BBG 10 μg (95.2%), OxATP 1 μg(92.0%) and A-438079 3 μg (93.8%) treated groups when compared to the saline group(72.4%). No significant difference was observed among the BBG 10 μg, OxATP 1 μg and A-438079 3 μg group. Clinical trial: N/A ......by MedChemexpress Co., Ltd.|
|A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. ......by Target Molecule Corp.|
|Appearance:White to off-white Solid||EBNumber:EB000017752|
|DMSO||by MedChemexpress Co., Ltd.|
|Company||Price and Availability||Country/Region|
|Apexbio Technology LLC||USA|
|Cayman Chemical Company||10mg/USD130()||USA|
|Hello Bio Inc.||10mg/USD129()||USA|
|MedChemexpress Co., Ltd.||10mg/USD120(In stock);50mg/USD466(In stock)||USA|
|Santa Cruz Biotechnology, Inc.||10mg/USD165()||USA|
|Selleck Chemicals LLC||USA|
|Shanghai Haoyuan Chemexpress Co., Ltd.||10mg/USD120(In stock);50mg/USD466(In stock)||China|
|Target Molecule Corp.||2mg/USD44();5mg/USD83();10mg/USD126();25mg/USD234();50mg/USD350()||USA|
|Tocris Bioscience Inc.||10mg/USD165()||USA|
|ATP (disodium salt)||987-65-5||C10H14N5Na2O13P3||551.14|
. Ketan Chu, Bo Yin, Jingye Wang, Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus. J Neuroinflammation. 2012; 9: 69.