• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1365267-27-1 (X-376)

1

Identification

X-376 X-376
Name X-376
Formula C25H25Cl2FN6O3
MW 547.41
CAS No. 1365267-27-1
EINECS
Smiles O=C(C1=NN=C(N)C(O[[email protected]@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4CCN(C)CC4)=O)C=C3
Synonyms (R)-6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide
InChI InChI=1S/C25H25Cl2FN6O3/c1-14(21-17(26)7-8-18(28)22(21)27)37-20-13-19(31-32-23(20)29)24(35)30-16-5-3-15(4-6-16)25(36)34-11-9-33(2)10-12-34/h3-8,13-14H,9-12H2,1-2H3,(H2,29,32)(H,30,35)/t14-/m1/s1
2

Introduction

Background Information

X-396 is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK po ......by BOC Sciences
Ensartinib is a potent inhibitor of ALK, which is used to treat non-small-cell lung cancer. IC50: In Vitro: Ensartinib is a selective ALK inhibitor, and provids promising advantages in terms of both clinical activity and safety[1]. In Vivo: ......by MedChemexpress Co., Ltd.
X-396 is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a series of tumors; ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) Shelf life: >2 years if stored properly Drug formulation: ......by MedKoo Biosciences, Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000016341

Storage condition

Solubility

DMSO: ≥ 37 mg/mL by CHEMSCENE, LLC
DMSO: ≥ 37 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Protein Tyrosine Kinase/RTK
Target ALK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
X-376 - Phase 1 Clinical
X-376 - Phase 3
7

Safety Data of X-376

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC USA
MedChemexpress Co., Ltd. 2mg/USD140(In stock);5mg/USD280(In stock);10mg/USD450(In stock);25mg/USD950(In stock);50mg/USD1500(In stock);100mg/USD2400(In stock) USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
10

Related Products

Other Forms of 1365267-27-1

Name CAS No Formula MW

Recommended Compounds in ALK

Name CAS No Formula MW
PF-06463922 1454846-35-5 C21H19FN6O2 406.41
CEP-37440 1391712-60-9 C30H38ClN7O3 580.12
HG-14-10-04 1356962-34-9 C29H34ClN7O 532.08
LDK378 (dihydrochloride) 1380575-43-8 C28H38Cl3N5O3S 631.06
LDK378 1032900-25-6 C28H36ClN5O3S 558.14
AZD-3463 1356962-20-3 C24H25ClN6O 448.95
CEP-28122 1022958-60-6 C28H35ClN6O3 539.07
AP26113 1197958-12-5 C26H34ClN6O2P 529.01
Crizotinib (hydrochloride) 1415560-69-8 C21H23Cl3FN5O 486.8
ALK inhibitor 2 761438-38-4 C23H28ClN7O3S 518.03
ALK inhibitor 1 761436-81-1 C23H28BrN7O3S 562.48
1-Piperidineacetamide, 4-[3-methoxy-4-[[7-(2-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]- 1233145-49-7 C27H30N6O3 486.57
ASP3026 1097917-15-1 C29H40N8O3S 580.74
GSK1838705A 1116235-97-2 C27H29FN8O3 532.57
A 83-01 909910-43-6 C25H19N5S 421.52
CH5424802 1256580-46-7 C30H34N4O2 482.62
Crizotinib 877399-52-5 C21H22Cl2FN5O 450.34
NVP-TAE 684 761439-42-3 C30H40ClN7O3S 614.2
Belizatinib 1357920-84-3 C33H44FN5O3 577.73
Brigatinib 1197953-54-0 C29H39ClN7O2P 584.09

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

X-376

Tags: buy 1365267-27-1 IC50 | 1365267-27-1 price | 1365267-27-1 cost | 1365267-27-1 solubility | 1365267-27-1 purchase | 1365267-27-1 manufacturer | 1365267-27-1 research buy | 1365267-27-1 order | 1365267-27-1 MSDS | 1365267-27-1 chemical structure | 1365267-27-1 Storage condition | 1365267-27-1 molecular weight | 1365267-27-1 mw | 1365267-27-1 datasheet | 1365267-27-1 supplier | 1365267-27-1 cell line | 1365267-27-1 NMR | 1365267-27-1 MS | 1365267-27-1 IR | 1365267-27-1 solubility | 1365267-27-1 Safe information | 1365267-27-1 Qc and Spectral Information | 1365267-27-1 Clinical Information | 1365267-27-1 Clinical Trial | 1365267-27-1 Route of Synthesis | 1365267-27-1 storage condition | 1365267-27-1 diseases and conditions | 1365267-27-1 flash point | 1365267-27-1 boiling point | 1365267-27-1 melting point | 1365267-27-1 storage condition | 1365267-27-1 brand