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80433-71-2 (Levoleucovorin (Calcium))



Levoleucovorin (Calcium) Levoleucovorin (Calcium)
Name Levoleucovorin (Calcium)
Formula C20H21CaN7O7
MW 511.5
CAS No. 80433-71-2
Smiles O=C1C2=C(NC[[email protected]](CNC3=CC=C(C(N[[email protected]](C([O-])=O)CCC([O-])=O)=O)C=C3)N2C=O)NC(N)=N1.[Ca+2]
Synonyms Calcium levofolinate;Elvorine;Isovorin;CL307782; calcium (S)-2-(4-((((S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioate
InChI InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12-,13-;/m0./s1


Levoleucovorin calcium is the calcium salt of Levoleucovorin, which is the enantiomerically active form of folinic acid. IC50 value: Target: Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.

Background Information

Calcium Levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. ......by BOC Sciences
L-leucovorin is the active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Shelf life: >2 years if stored properly Drug formulation: ......by MedKoo Biosciences, Inc.
Calcium Levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. ......by Selleck Chemicals LLC
Calcium Levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000016194

Storage condition


DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro Water 9 mg/mL (17.59 mM); DMSO<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target Antifolate
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Levoleucovorin (Calcium) - Launched

Safety Data of Levoleucovorin (Calcium)


Spectral Information


Suppliers List

Company Price and Availability Country/Region
AK Scientific, Inc. USA
AbMole BioScience 25mg/USD160(In Stock) USA
Abblis Chemicals LLC 10mg/USD110(In Stock) USA
Aladdin 10mg/RMB649();250 mg/RMB6999() China
BOC Sciences
CHEMSCENE, LLC 100mg/USD60();500mg/USD72() USA
Carbosynth Limited 250mg/USD110()
Lianyungang Jinkang Pharmaceutical Technology Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60();500mg/USD72() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 10mg/USD110(In stock) USA
Shandong Kingnod Pharmaceuticals Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();500mg/USD72() China
Target Molecule Corp. 10mg/USD89();100mg/USD368() USA

Related Products

Other Forms of 80433-71-2

Name CAS No Formula MW

Recommended Compounds in Antifolate

Name CAS No Formula MW
Trimethoprim 738-70-5 C14H18N4O3 290.32
Calcium N5-methyltetrahydrofolate 26560-38-3 C20H23CaN7O6 497.52
Folinic acid 58-05-9 C20H23N7O7 473.44
Folinic acid (calcium salt pentahydrate) 6035-45-6 C20H21CaN7O7 511.5
Pemetrexed (disodium hemipenta hydrate) (1:2:2.5) 357166-30-4 C40H48N10Na4O17 1032.83
Pemetrexed (disodium) 150399-23-8 C20H19N5Na2O6 471.37
Folinic acid (Calcium) 1492-18-8 C20H21CaN7O7 511.50144
Pyrimethamine 58-14-0 C12H13ClN4 248.71
Levomefolate (calcium) 151533-22-1 C40H48CaN14O12 956.97
Levomefolic acid 31690-09-2 C20H25N7O6 459.46
Methotrexate 59-05-2 C20H22N8O5 454.44
Pemetrexed 137281-23-3 C20H21N5O6 427.41
Pralatrexate 146464-95-1 C23H23N7O5 477.47
QN254 C17H18ClN5O2 359.81
P218 C18H24N4O4 360.41
P65 C14H15Cl3N4O2 377.65
WR99210 47326-86-3 C14H18Cl3N5O2 394.68
Pemetrexed (disodium) 150399-23-8 C20H19N5Na2O6 471.37429856
Levomefolate (calcium) 151533-22-1 C20H23CaN7O6 497.5179
Cycloguanil D6 C11H8D6ClN5 257.7523

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information

Levoleucovorin (Calcium)

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