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1247819-59-5 (P 22077)

1

Identification

P 22077 P 22077
Name P 22077
Formula C12H7F2NO3S2
MW 315.32
CAS No. 1247819-59-5
EINECS
Smiles CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O
Synonyms P22077;P-22077; 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone
InChI InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3
2

Introduction

P22077 is a potent inhibitor of ubiquitin-specific protease (USP) 7 (EC50=8.6 uM), P22077 also inhibits the closely related deubiquitinase (DUB) USP47. IC50 Value: 8.6 uM (EC50) [1] Target: USP7; USP47 in vitro: P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression.

Background Information

P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P2207 ......by BOC Sciences
P 22077 is an inhibitor of ubiquitin-specific protease 7 (USP7) with an EC50 of 8.01 μM, and also inhibits USP47, with an EC50 of 8.74 μM. ......by MedChemexpress Co., Ltd.
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47. ......by Selleck Chemicals LLC
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47. ......by Target Molecule Corp.
Inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000014768

Storage condition

Store at +4°C by Tocris Bioscience Inc.

Solubility

DMSO 63 mg/ml; Water <1 mg/ml by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 63 mg/mL (199.79 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target Deubiquitinase
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
P 22077 - Discovery
P 22077 - No Development Reported
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Safety Data of P 22077

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences 100mg/USD298(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD94();50mg/USD354() USA
MedChemexpress Co., Ltd. 10mg/USD94();50mg/USD354() USA
Selleck Chemicals LLC 10mg/USD147(In stock);50mg/USD370(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD94();50mg/USD354() China
Target Molecule Corp. 10mg/USD125();25mg/USD244();50mg/USD328() USA
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 1247819-59-5

Name CAS No Formula MW

Recommended Compounds in Deubiquitinase

Name CAS No Formula MW
DUBs-IN-2 924296-19-5 C15H9N5O 275.26
ML-323 1572414-83-5 C23H24N6 384.48
HBX 19818 1426944-49-1 C25H28ClN3O 421.96
b-AP15 1009817-63-3 C22H17N3O6 419.39
SJB2-043 63388-44-3 C17H9NO3 275.26
P005091 882257-11-6 C12H7Cl2NO3S2 348.22
IU1 314245-33-5 C18H21FN2O 300.37
PR-619 2645-32-1 C7H5N5S2 223.28
USP7/USP47 inhibitor 1247825-37-1 C18H11Cl2N3O3S3 484.4
BAY 11-7082 19542-67-7 C10H9NO2S 207.249
DUBs-IN-3 924296-17-3 C16H9N5O 287.28
DUBs-IN-1 924296-18-4 C20H11N5O 337.33
WP1130 856243-80-6 C19H18BrN3O 384.27
VLX1570 1431280-51-1 C23H17F2N3O6 469.39
LDN-57444 668467-91-2 C17H11Cl3N2O3 397.64
USP7-IN-1 1381291-36-6 C23H24ClN3O3 425.91
NSC632839 157654-67-6 C21H22ClNO 339.8585
ML364 1991986-30-1 C24H18F3N3O3S2 0.0
Cadmium pyrithione C10H8CdN2O2S2 364.72
IU1-47 670270-31-2 C19H23ClN2O 330.85

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

P 22077

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