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870061-27-1 (A 839977)

1

Identification

A 839977 A 839977
Name A 839977
Formula C19H14Cl2N6O
MW 413.26
CAS No. 870061-27-1
EINECS
Smiles ClC1=C(Cl)C(N2N=NN=C2NCC3=CC=CC=C3OC4=NC=CC=C4)=CC=C1
Synonyms A-839977;A839977; 1-(2,3-dichlorophenyl)-N-(2-(pyridin-2-yloxy)benzyl)-1H-tetrazol-5-amine
InChI InChI=1S/C19H14Cl2N6O/c20-14-7-5-8-15(18(14)21)27-19(24-25-26-27)23-12-13-6-1-2-9-16(13)28-17-10-3-4-11-22-17/h1-11H,12H2,(H,23,24,26)
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Introduction

A-839977 is a novel and selective P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). IC50 Value: Target: P2X7 in vitro: A-839977 potently (IC50=20-150 nM) blocked BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors.

Background Information

Potent P2X7 antagonist blocking BzATP-evoked calcium influx ......by AOBIOUS INC
A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta ......by BOC Sciences
A-839977 is a novel and selective P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). IC50 Value: Target: P2X7 in vitro: A-839977 potently (IC50=20-150 nM) blocked BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors. A-839977 also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells [1]. in vivo: Systemic administration of A-839977 dose-dependently reduced thermal hyperalgesia produced by intraplantar administration of complete Freund's adjuvant (CFA) (ED50=100 micromol/kg, i.p.) in rats. A-839977 also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice (ED50=40 micromol/kg, i.p.), but the antihyperalgesic effects of A-839977 were completely absent in IL-1alphabeta knockout mice [1]. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000013625

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target P2X Receptor
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A 839977 - No Development Reported
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Safety Data of A 839977

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC 1mg/USD15() USA
Apexbio Technology LLC 10mg/USD128(In stock) USA
BOC Sciences
CHEMSCENE, LLC USA
MedChemexpress Co., Ltd. 10mg/USD135(In stock);50mg/USD550(In stock) USA
Santa Cruz Biotechnology, Inc. 10mg/USD175() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD135(In stock);50mg/USD550(In stock) China
Tocris Bioscience Inc. 10mg/USD179() USA
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Related Products

Other Forms of 870061-27-1

Name CAS No Formula MW

Recommended Compounds in P2X Receptor

Name CAS No Formula MW
ATP (disodium salt) 987-65-5 C10H14N5Na2O13P3 551.14
Lappaconitine 32854-75-4 C32H44N2O8 584.7
A-317491 475205-49-3 C33H27NO8 565.57
A 438079 (hydrochloride) 899431-18-6 C13H10Cl3N5 342.61
A 438079 899507-36-9 C13H9Cl2N5 306.15
GW791343 (trihydrochloride) 309712-55-8 C20H27Cl3F2N4O 483.81
GW791343 (dihydrochloride) 1019779-04-4 C20H26Cl2F2N4O 447.35
AF 353 865305-30-2 C14H17IN4O2 400.21
KN-62 127191-97-3 C38H35N5O6S2 721.84
A-740003 861393-28-4 C26H30N6O3 474.55
A-804598 1125758-85-1 C19H20N2O3 324.37
PSB-12062 55476-47-6 C22H22ClN5O2 423.9
AZD9056 (hydrochloride) 345303-91-5 C24H36Cl2N2O2 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

A 839977

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