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60-56-0 (Methimazole)



Methimazole Methimazole
Name Methimazole
Formula C4H6N2S
MW 114.17
CAS No. 60-56-0
EINECS 200-482-4
Smiles SC1=NC=CN1C
Synonyms 2-Mercapto-1-methylimidazole; 1-Methylimidazole-2-thiol; Thiamazole; 1-methyl-1H-imidazole-2-thiol
InChI InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)


Methimazole(Tapazole, Northyx) is an antithyroid medicine. Target: Others Methimazole is an antithyroid drug, and part of the thioamide group.

Background Information

Methimazole (also known as Tapazole or Thiamazole or MMI) is an antithyroid drug,and part of the thioamide group. Like its counterpart propylthiouracil, a major side effect of treatment is agranulocytosis. ......by BOC Sciences
Methimazole(Tapazole, Northyx) is an antithyroid medicine. Target: Others Methimazole is an antithyroid drug, and part of the thioamide group. Like its counterpart propylthiouracil, a major side effect of treatment is agranulocytosis. Methimazole is a drug used to treat hyperthyroidism, a condition that occurs when the thyroid gland begins to produce an excess of thyroid hormone. The drug may also be taken before thyroid surgery to lower thyroid hormone levels and minimize the effects of thyroid manipulation. Additionally, Methimazole is used in the veterinary setting to treat hyperthyroidism in cats. Methimazole inhibits the enzyme thyroperoxidase, which normally acts in thyroid hormone synthesis by oxidizing the anion iodide (I-) to iodine (I0), facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin, a necessary step in the synthesis of triiodothyronine (T3) and thyroxine. It does not inhibit the action of the sodium-dependent iodide transporter located on follicular cells' basolateral membranes. Inhibition of this step requires competitive inhibitors such as perchlorate and thiocyanate. It acts at CXCL10. ......by MedChemexpress Co., Ltd.
Methimazole is an antithyroid medicine. ......by Selleck Chemicals LLC
Methimazole is an antithyroid medicine. ......by Target Molecule Corp.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012788

Storage condition


DMSO 23 mg/mL (201 mM); Water 23 mg/mL (201 mM) by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 23 mg/mL (201.45 mM); Water23 mg/mL (201.45 mM); Ethanol23 mg/mL (201.45 mM) by Selleck Chemicals LLC

Mechanism and Indication

Signaling Pathways Others
Target Others
Research Area Endocrinology

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Methimazole - Launched

Safety Data of Methimazole

Hazard Symbols : Xn
Risk Statements : R43;R62;R63
Safety Statements : S36/37
HS Code : 29332990
RTECS : NI8615000
WGKGermany : 3

Spectral Information


Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Beijing Merson Pharmaceutical Co., Ltd. China
Beijing XJFT Biotech Development Co., Ltd CHINA
Beijing Yanjing Pharmaceutical Co., Ltd. China
Changzhou Tianhua Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 1g/USD50(In stock);5g/USD80(In stock) USA
Pure Chemistry Scientific Inc. 5g/USD861(In stock) USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5g/USD33(Get quote);25g/USD84(Get quote) China
Target Molecule Corp. 2mg/USD20();10mg/USD41();50mg/USD83();200mg/USD122() USA

Related Products

Other Forms of 60-56-0

Name CAS No Formula MW
1,3-Dihydro-1-(methyl-d3)-2H-imidazole-2-thione 1160932-07-9 C4H6N2S 114.17

Recommended Compounds in Others

Name CAS No Formula MW
(R)-(+)-Etomoxir (sodium salt) 828934-41-4 C15H18ClNaO4 320.74
Dictamine 484-29-7 C12H9NO2 199.21
Liothyronine (sodium) 55-06-1 C15H11I3NNaO4 672.96
Afobazole (hydrochloride) 173352-39-1 C15H22ClN3O2S 343.87
FPH2 957485-64-2 C14H16ClN5O2S 353.83
α-Tocopherol (phosphate) 38976-17-9 C29H51O5P 510.69
BAMB-4 891025-25-5 C15H12N2O2 252.27
LDN-27219 312946-37-5 C20H16N4O2S2 408.5
ISO-1 478336-92-4 C12H13NO4 235.24
Aurothioglucose 12192-57-3 C6H11AuO5S 392.18
Oxybenzone 131-57-7 C14H12O3 228.24
ITX3 347323-96-0 C22H17N3OS 371.45
Cardiogreen 3599-32-4 C43H47N2NaO6S2 774.96
Skp2 Inhibitor C1 432001-69-9 C18H13BrN2O4S2 465.34
INH1 313553-47-8 C18H16N2OS 308.4
PF6-AM 1268491-69-5 C33H31BO12 630.4
XEN445 1515856-92-4 C18H17F3N2O3 366.33
Methyl N-ethyl-N-4-(5-nitro-2,1-benzisothiazol-3-yl)azophenyl-alaninate 52239-04-0 C19H19N5O4S 413.45
1,4-bis(Butylamino)anthraquinone 17354-14-2 C22H26N2O2 350.45
CID 797718 370586-05-3 C12H11NO3 217.22

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information


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