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80418-24-2 (Notoginsenoside R1)

1

Identification

Notoginsenoside R1 Notoginsenoside R1
Name Notoginsenoside R1
Formula C47H80O18
MW 933.13
CAS No. 80418-24-2
EINECS
Smiles C[[email protected]]([[email protected]@](C[[email protected]]1O)([H])[[email protected]]2(CC[[email protected]@H]3O)C)(C[[email protected]](O[[email protected]@](O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]4O)([H])[[email protected]@H]4O[[email protected]@](OC[[email protected]@H](O)[[email protected]@H]5O)([H])[[email protected]@H]5O)[[email protected]@]2([H])C3(C)C)[[email protected]]6([[email protected]@]1([H])[[email protected]]([[email protected]@](CC/C=C(C)/C)(C)O[[email protected]@H]([[email protected]@H]([[email protected]@H](O)[[email protected]@H]7O)O)O[[email protected]@H]7CO)([H])CC6)C
Synonyms Sanchinoside R1;Sanqi glucoside R1; (2S,3R,4S,5S,6R)-2-(((S)-2-((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-6-(((2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,12-dihydroxy-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methylhept-5-en-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
InChI InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1
2

Introduction

Background Information

Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects. IC50 value: Target: In vitro: In vivo: Notoginsenoside R1 significantly reduce blood pressure in spontaneously hypertensive rats and induce nitric oxide generation through increasing the phosphorylation of iNOS. Notoginsenoside R1 reduces the caudal blood pressure of spontaneously hypertensive rats through induction of iNOS regulated by long non-coding RNA AK094457 [1]. The mice with notoginsenoside R1 treatment showed significant amelioration in the cognitive function and increased choline acetyl transferase expression, as compared to the vehicle treated mice. Notoginsenoside R1 treatment inhibited Aβ accumulation and increased insulin degrading enzyme expression in both APP/PS1 mice and N2a-APP695sw cells [2]. In Notoginsenoside R1 treated rats, expression of TGF-β1and Smad3 at each time point was down-regulated, with statistical significance(P0.05) compared with that in the NDMA group [3]. ......by MedChemexpress Co., Ltd.
Notoginsenoside R1 has been shown to exhibit antooxidant,anti-inflammatory,antiapoptotic,and immune-stimulatory properties. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000011629

Storage condition

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Neuronal Signaling
Target Amyloid-β
Research Area Others
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Notoginsenoside R1 - Not Found
Notoginsenoside R1 - No Development Reported
7

Safety Data of Notoginsenoside R1

Hazard Symbols : Xn
Risk Statements : 22
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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
ALB Technology Limited 20mg/USD70() China
Abcam 5mg/USD161();10mg/USD268();25mg/USD536() USA
Apexbio Technology LLC 20mg/USD100() USA
AvaChem Scientific LLC USA
CHEMSCENE, LLC USA
Carbosynth Limited 10mg/USD95();25mg/USD190();50mg/USD350();100mg/USD485();250mg/USD1050()
MedChemexpress Co., Ltd. 5mg/USD60(In stock);10mg/USD90(In stock) USA
Santa Cruz Biotechnology, Inc. 5mg/USD141();10mg/USD204() USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Sigma-Aldrich, Inc. 10mg/USD224();50mg/USD685() USA
Target Molecule Corp. 10mg/USD101();25mg/USD185();100mg/USD428() USA
Wuhan ChemFaces Biochemical Co., Ltd. 20mg/USD70() China
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Related Products

Other Forms of 80418-24-2

Name CAS No Formula MW

Recommended Compounds in Amyloid-β

Name CAS No Formula MW
Schisantherin B 58546-55-7 C28H34O9 514.56
Carbazochrome (sodium sulfonate) 51460-26-5 C10H17N4NaO8S 376.32
ARN-2966 102212-26-0 C12H12N2O 200.24
Geniposide 24512-63-8 C17H24O10 388.37
Hoechst 34580 23555-00-2 C27H29N7 451.57
Frentizole 26130-02-9 C15H13N3O2S 299.35
NC 758 3687-18-1 C3H9NO3S 139.17
9H-Fluoren-2-amine, 7-bromo-N,N-dimethyl- 677746-25-7 C15H14BrN 288.18
gamma-Secretase Modulators 937812-80-1 C26H24F3N3O3 483.48
Semagacestat 425386-60-3 C19H27N3O4 361.44
Deferoxamine mesylate 138-14-7 C26H52N6O11S 656.79
D-Proline, 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-, 2,2'-bis[[[[(tetrahydro-2H-pyran-4-yl)oxy]carbonyl]oxy]methyl] ester 1819986-22-5 C30H44N2O14 656.68
FPS-ZM1 945714-67-0 C20H22ClNO 327.85
AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE 131602-53-4 C45H81N13O14S 1060.28
Hoechst 34580 (trihydrochloride) 911004-45-0 C27H32Cl3N7 560.95
MDR-1339 C20H22O4 326.39
SKF-64346 C29H31NO3 441.56

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

13

More Information

Notoginsenoside R1

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