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1243087-60-6 (D376-0053)

1

Identification

D376-0053 D376-0053
Name D376-0053
Formula C20H19FN2O2S
MW 370.44
CAS No. 1243087-60-6
EINECS
Smiles C1C(C)=CC(OCC2=NC(C)=C(C(=O)NC3C=CC=C(F)C=3)S2)=C(C)C=1
Synonyms
InChI InChI=1S/C20H19FN2O2S/c1-12-7-8-13(2)17(9-12)25-11-18-22-14(3)19(26-18)20(24)23-16-6-4-5-15(21)10-16/h4-10H,11H2,1-3H3,(H,23,24)
2

Introduction

D376-0053 is a novel cyclin-dependent kinase 8 (CDK8) inhibitor. The inhibition rate is 12.1±2.8% at 10 μM. CDK8 gene expression correlates with increased mortality in colorectal, breast, and ovarian cancers and its overexpression is essential for the proliferation of cancer cells. Due to its key roles in oncogenesis, CDK8 has recently attracted considerable attention. Inhibitors of CDK8 offer a novel strategy for the treatment of various cancers.

Background Information

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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB100692361

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of D376-0053

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AMEDCHEM CHINA
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Related Products

Other Forms of 1243087-60-6

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

D376-0053

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