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(GPR40 agonist 2)

1

Identification

GPR40 agonist 2 GPR40 agonist 2
Name GPR40 agonist 2
Formula C25H22O3
MW 370.44
CAS No.
EINECS
Smiles C(O)(=O)C#CC1=CC=C(OCC2C=CC=C(C3=C(C)C=C(C)C=C3C)C=2)C=C1
Synonyms Compound 10
InChI InChI=1S/C25H22O3/c1-17-13-18(2)25(19(3)14-17)22-6-4-5-21(15-22)16-28-23-10-7-20(8-11-23)9-12-24(26)27/h4-8,10-11,13-15H,16H2,1-3H3,(H,26,27)
2

Introduction

GPR40 agonist 2 (Compound 10) is a novel GPR40 agonist with an EC50 of 2.87±0.73 μM. GPR40, also known as free fatty acid receptor 1 (FFAR1), is a member of G protein-coupled receptors (GPCR) family and has emerged as an attractive target for the treatment of type 2 diabetes mellitus.

Background Information

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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB100167002

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target GPR40
Research Area Metabolic Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of GPR40 agonist 2

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AMEDCHEM CHINA
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Related Products

Other Forms of

Name CAS No Formula MW

Recommended Compounds in GPR40

Name CAS No Formula MW
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 455.45
AMG 837 (sodium salt) 865231-45-4 C26H20F3NaO3 460.42
GPR40 Activator 1 1309435-60-6 C31H31NO3S 497.65
AMG 837 865231-46-5 C26H21F3O3 438.44
TUG-770 1402601-82-4 C19H14FNO2 307.32
GW9508 885101-89-3 C22H21NO3 347.41
TAK-875 1000413-72-8 C29H32O7S 524.63
GW-1100 306974-70-9 C27H25FN4O4S 520.58
GPR40 Activator 2 1312787-30-6 C28H29NO6S2 539.66
DC260126 346692-04-4 C32H31N5O 501.62
M-I C19H22O5S 362.44
T-1676427 1000414-39-0 C29H32O8S 540.62
JTT-851 C23H28O3 352.47
Astellas C27H30N4O4 474.55
MK-2305 905723-46-8 C19H13ClF3NO4S 443.82
Mochida 1469495-84-8 C30H35NO6S 537.67
BMS-986118 1610562-74-7 C25H28ClF3N4O4 540.96
AM-6226 C32H36F2O4 522.62
GPR40 agonist 1 1312788-44-5 C24H20O3 356.41
GPR40 agonist 3 C23H18O3 342.39

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

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References

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More Information

GPR40 agonist 2

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