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(AM-6226)

1

Identification

AM-6226 AM-6226
Name AM-6226
Formula C32H36F2O4
MW 522.62
CAS No.
EINECS
Smiles C1C(F)=C(C2C([[email protected]@H]3CCCC3(C)C)=CC(COC3C(F)=C([[email protected]](CC)CC(=O)O)C=CC=3)=CC=2)C=C(OC)C=1 |&1:6,21|
Synonyms
InChI InChI=1S/C32H36F2O4/c1-5-21(17-30(35)36)23-8-6-10-29(31(23)34)38-19-20-11-13-24(26-18-22(37-4)12-14-28(26)33)25(16-20)27-9-7-15-32(27,2)3/h6,8,10-14,16,18,21,27H,5,7,9,15,17,19H2,1-4H3,(H,35,36)/t21-,27+/m1/s1
2

Introduction

AM-6226 is a potent and orally bioavailable GPR40 full agonist (EC50=120 nM) that displays efficacy in non-human primates. GPR40 (FFA1) is a G-protein-coupled receptor, primarily expressed in pancreatic islets and enteroendocrine L-cells, when activated elicits increased insulin secretion only in the presence of elevated glucose levels.

Background Information

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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB100150115

Storage condition

Solubility

5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target GPR40
Research Area Metabolic Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of AM-6226

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AMEDCHEM CHINA
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Related Products

Other Forms of

Name CAS No Formula MW

Recommended Compounds in GPR40

Name CAS No Formula MW
AMG 837 (calcium hydrate) 1259389-38-2 C26H22F3O4- 455.45
AMG 837 (sodium salt) 865231-45-4 C26H20F3NaO3 460.42
GPR40 Activator 1 1309435-60-6 C31H31NO3S 497.65
AMG 837 865231-46-5 C26H21F3O3 438.44
TUG-770 1402601-82-4 C19H14FNO2 307.32
GW9508 885101-89-3 C22H21NO3 347.41
TAK-875 1000413-72-8 C29H32O7S 524.63
GW-1100 306974-70-9 C27H25FN4O4S 520.58
GPR40 Activator 2 1312787-30-6 C28H29NO6S2 539.66
DC260126 346692-04-4 C32H31N5O 501.62
M-I C19H22O5S 362.44
T-1676427 1000414-39-0 C29H32O8S 540.62
JTT-851 C23H28O3 352.47
Astellas C27H30N4O4 474.55
MK-2305 905723-46-8 C19H13ClF3NO4S 443.82
Mochida 1469495-84-8 C30H35NO6S 537.67
BMS-986118 1610562-74-7 C25H28ClF3N4O4 540.96
GPR40 agonist 1 1312788-44-5 C24H20O3 356.41
GPR40 agonist 2 C25H22O3 370.44
GPR40 agonist 3 C23H18O3 342.39

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

AM-6226

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