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1335490-39-5 (BAY-958)

1

Identification

BAY-958 BAY-958
Name BAY-958
Formula C17H16FN5O3S
MW 389.4
CAS No. 1335490-39-5
EINECS
Smiles C1(CS(N)(=O)=O)=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1
Synonyms BAY-958; BAY 958; BAY958;
InChI InChI=1S/C17H16FN5O3S/c1-26-15-8-12(18)5-6-14(15)16-20-10-21-17(23-16)22-13-4-2-3-11(7-13)9-27(19,24)25/h2-8,10H,9H2,1H3,(H2,19,24,25)(H,20,21,22,23)
2

Introduction

BAY-958 is a potent PTEFb/CDK9 inhibitor that also displays very high kinase selectivity, even within the CDK family (in-house kinase panel: IC50 CDK9/CycT1: 11 nM). BAY-958 also exhibits good antiproliferative activity in vitro, for example against HeLa cells (IC50: 1000 nM) and MOLM‐13 cells (IC50: 280 nM). 

Background Information

BAY-958 is a potent and selective PTEFb/CDK9 inhibitor. ......by MedKoo Biosciences, Inc.
BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1; displays 52/82/291/>900/>900-fold selectivity compared to CDK2/1/4/6/7; exhibits good antiproliferative activity in vitro, for example against HeLa cells (IC50=1000 nM) and MOLM-13 cells (IC50=280 nM); displays efficient cytotoxic activity against CLL cells in vitro, decreases CLL MCL-1 protein levels and triggers apoptosis rather than inhibiting proliferation; decreases splenic human CLL numbers in xenografted NSG mice, shows significant CLL cell cytotoxicity in TCL1 transgenic mice. ......by ProbeChem
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB100127123

Storage condition

Solubility

5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of BAY-958

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
MedKoo Biosciences, Inc. USA
ProbeChem
10

Related Products

Other Forms of 1335490-39-5

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

BAY-958

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