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106083-71-0 (Radafaxine (hydrochloride))

1

Identification

Radafaxine (hydrochloride) Radafaxine (hydrochloride)
Name Radafaxine (hydrochloride)
Formula C13H19Cl2NO2
MW 292.2
CAS No. 106083-71-0
EINECS
Smiles O[[email protected]]1(C2=CC=CC(Cl)=C2)[[email protected]](C)NC(C)(C)CO1.[H]Cl
Synonyms GW-353162A;BW-306U; (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol hydrochloride
InChI InChI=1S/C13H18ClNO2.ClH/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10;/h4-7,9,15-16H,8H2,1-3H3;1H/t9-,13+;/m0./s1
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Introduction

Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

Background Information

Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator. ......by AbMole BioScience
The hydrochloride salt form of Radafaxine which is also an active metabolism of Bupropion and has been found to be an inhibitor of dopamine and norepinephrine transporter and a regulator of nAChR family. The Phase II trail has already been discontinued fo ......by BOC Sciences
Radafaxine, also known BW-306U and GW-353162, is a dopamine reuptake inhibitor potentially for the reatment of restless legs syndrome and major depression. ......by MedKoo Biosciences, Inc.
A potent metabolite of bupropion; selectivly inhibits the reuptake of norepinephrine over dopamine; DAT and NET transporters inhibitor, and nAChR family modulator. DepressionApproved ......by ProbeChem
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000071949

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

DMSO 12 mg/ml by CHEMSCENE, LLC
DMSO 12 mg/ml by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target Monoamine Transporter
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Radafaxine (hydrochloride) - Launched
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Safety Data of Radafaxine (hydrochloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 5mg/USD102();10mg/USD192() USA
MedChemexpress Co., Ltd. 5mg/USD102();10mg/USD192() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD102();10mg/USD192() China
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Related Products

Other Forms of 106083-71-0

Name CAS No Formula MW

Recommended Compounds in Monoamine Transporter

Name CAS No Formula MW
Tetrabenazine (Racemate) 718635-93-9 C19H27NO3 317.4226
NBI-98854 171598-74-6 C19H29NO3 319.44
NBI-98782 85081-18-1 C19H29NO3 319.44
Reserpine (hydrochloride) 16994-56-2 C33H41ClN2O9 645.14
Reserpine 50-55-5 C33H40N2O9 608.68
Tetrabenazine ((+)-) 1026016-83-0 C19H27NO3 317.4226
Corticosterone 50-22-6 C21H30O4 346.46
Tetrabenazine D6 1392826-25-3 C19H21D6NO3 323.46
Vanilpyruvic acid 1081-71-6 C10H10O5 210.1834
Tetrabenazine (Racemate) 718635-93-9 C19H27NO3 317.42
Lobelane 530-51-8 C22H29N 307.47
GZ-11610 2141973-99-9 C19H25NO 283.41
GZ-793A 1356447-90-9 C26H37NO4 427.58
Tetrabenazine 58-46-8 C19H27NO3 317.42
(+)-Tetrabenazine D6 1977511-05-9 C19H21D6NO3 323.46

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Radafaxine (hydrochloride)

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