• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

1354037-26-5 (KH-CB19)

1

Identification

KH-CB19 KH-CB19
Name KH-CB19
Formula C15H13Cl2N3O2
MW 338.19
CAS No. 1354037-26-5
EINECS
Smiles O=C(C(N1C)=C(/C(C#N)=CN)C2=C1C(Cl)=C(Cl)C=C2)OCC
Synonyms KH-CB-19; (E)-ethyl 3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
InChI InChI=1S/C15H13Cl2N3O2/c1-3-22-15(21)14-11(8(6-18)7-19)9-4-5-10(16)12(17)13(9)20(14)2/h4-6H,3,18H2,1-2H3/b8-6-
2

Introduction

KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4). IC50 value: 20 nM (CLK1) [1] Target: CLK1/4 inhibitor in vitro: KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform.

Background Information

Selective and potent inhibitor of CDC2-like kinase (CLK) 1 and 4 ......by AOBIOUS INC
KH-CB19, a CLK1/CLK4 inhibitor, has been found to probably restrain the phosphorylation of serine- and arginine-rich (SR) proteins. IC50: 20 nM for CLK1. ......by BOC Sciences
KH-CB19 is a potent and selective inhibitor of CDC2-like kinase (CLK) 1 and 4. KH-CB19 suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. ......by MedKoo Biosciences, Inc.
KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform; effectively suppresses phosphorylation of SR (serine/arginine) proteins SRp75 and SRp55 in cells; significantly reduces the basal expression of flTF as well as asHTF, also lowers TNF-α-induced expression of both TF mRNA splice variants to baseline in HMEC-1 cells. ......by ProbeChem
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000071097

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
KH-CB19 - Not Found
KH-CB19 - No Development Reported
7

Safety Data of KH-CB19

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 1mg/USD96();5mg/USD420() USA
MedChemexpress Co., Ltd. 1mg/USD96();5mg/USD420() USA
MedKoo Biosciences, Inc. USA
ProbeChem
Shanghai Haoyuan Chemexpress Co., Ltd. 1mg/USD96();5mg/USD420() China
10

Related Products

Other Forms of 1354037-26-5

Name CAS No Formula MW

Recommended Compounds in CDK

Name CAS No Formula MW
LY2857785 1619903-54-6 C26H36N6O 448.6
THZ2 1604810-84-5 C31H28ClN7O2 566.0527
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 573.66
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 513.07468
ML167 1285702-20-6 C19H17N3O3 335.36
AMG 925 1401033-86-0 C26H29N7O2 471.55
LDC000067 1073485-20-7 C18H18N4O3S 370.43
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 570.64
LEE011 (succinate) 1374639-75-4 C27H36N8O5 552.63
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 471.0
LEE011 1211441-98-3 C23H30N8O 434.54
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
Wogonin 632-85-9 C16H12O5 284.26
1-NM-PP1 221244-14-0 C20H21N5 331.41
WHI-P180 211555-08-7 C16H15N3O3 297.31
THZ1 1604810-83-4 C31H28ClN7O2 566.05
Senexin A 1366002-50-7 C17H14N4 274.32
CDK4-IN-1 1256963-02-6 C22H29ClN8 440.97
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 483.99
Purvalanol B 212844-54-7 C20H25ClN6O3 432.9

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

KH-CB19

Tags: buy 1354037-26-5 IC50 | 1354037-26-5 price | 1354037-26-5 cost | 1354037-26-5 solubility | 1354037-26-5 purchase | 1354037-26-5 manufacturer | 1354037-26-5 research buy | 1354037-26-5 order | 1354037-26-5 MSDS | 1354037-26-5 chemical structure | 1354037-26-5 Storage condition | 1354037-26-5 molecular weight | 1354037-26-5 mw | 1354037-26-5 datasheet | 1354037-26-5 supplier | 1354037-26-5 cell line | 1354037-26-5 NMR | 1354037-26-5 MS | 1354037-26-5 IR | 1354037-26-5 solubility | 1354037-26-5 Safe information | 1354037-26-5 Qc and Spectral Information | 1354037-26-5 Clinical Information | 1354037-26-5 Clinical Trial | 1354037-26-5 Route of Synthesis | 1354037-26-5 storage condition | 1354037-26-5 diseases and conditions | 1354037-26-5 flash point | 1354037-26-5 boiling point | 1354037-26-5 melting point | 1354037-26-5 storage condition | 1354037-26-5 brand