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50-22-6 (Corticosterone)

1

Identification

Corticosterone Corticosterone
Name Corticosterone
Formula C21H30O4
MW 346.46
CAS No. 50-22-6
EINECS 200-019-6
Smiles C[[email protected]@]12[[email protected]@H](C(CO)=O)CC[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])[[email protected]@H](O)C2)=O
Synonyms 17-Deoxycortisol;11β,21-Dihydroxyprogesterone;Kendall's compound B; (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
2

Introduction

Corticosterone is a sensitive inhibitor of monoamine transport. Target: OCT(organic cation transporter) Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands in rodents and other non-human animals.

Background Information

Extract from the adrenal cortex, is a sensitive inhibitor of monoamine transport. ......by BOC Sciences
Endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000069850

Storage condition

4°C by MedChemexpress Co., Ltd.
Store at RT by Tocris Bioscience Inc.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
Soluble to 100 mM in DMSO and to 10 mM in ethanol by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target Monoamine Transporter
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Corticosterone - Launched
Corticosterone - Phase 3
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Safety Data of Corticosterone

Hazard Symbols : Xi,N,Xn,T,F
Risk Statements : 43-40-39/23/24/25-23/24/25-11
Safety Statements : 36-22-45-36/37-16
RTECS : GM7650000
WGKGermany : 3
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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC 50mg/USD60() USA
Hubei Research Institute of Chemistry China
MedChemexpress Co., Ltd. 50mg/USD60() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD60() China
Tocris Bioscience Inc. USA
10

Related Products

Other Forms of 50-22-6

Name CAS No Formula MW

Recommended Compounds in Monoamine Transporter

Name CAS No Formula MW
Tetrabenazine (Racemate) 718635-93-9 C19H27NO3 317.4226
NBI-98854 171598-74-6 C19H29NO3 319.44
NBI-98782 85081-18-1 C19H29NO3 319.44
Reserpine (hydrochloride) 16994-56-2 C33H41ClN2O9 645.14
Reserpine 50-55-5 C33H40N2O9 608.68
Tetrabenazine ((+)-) 1026016-83-0 C19H27NO3 317.4226
Tetrabenazine D6 1392826-25-3 C19H21D6NO3 323.46
Radafaxine (hydrochloride) 106083-71-0 C13H19Cl2NO2 292.2
Vanilpyruvic acid 1081-71-6 C10H10O5 210.1834
Tetrabenazine (Racemate) 718635-93-9 C19H27NO3 317.42
Lobelane 530-51-8 C22H29N 307.47
GZ-11610 2141973-99-9 C19H25NO 283.41
GZ-793A 1356447-90-9 C26H37NO4 427.58
Tetrabenazine 58-46-8 C19H27NO3 317.42
(+)-Tetrabenazine D6 1977511-05-9 C19H21D6NO3 323.46

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

Corticosterone

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