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24144-92-1 (TMS)

1

Identification

TMS TMS
Name TMS
Formula C18H20O4
MW 300.35
CAS No. 24144-92-1
EINECS
Smiles COC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C(OC)=C1
Synonyms 2,4,3',5'-tetramethoxystilbene; (E)-1-(3,5-dimethoxystyryl)-2,4-dimethoxybenzene
InChI InChI=1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
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Introduction

Cancer Res. 2001 Nov 15;61(22):8164-70. J Med Chem. 2002 Jan 3;45(1):160-4. Breast Cancer Res Treat. 2011 Apr;126(3):779-89.

Background Information

TMS is a selective, competitive inhibitor of cytochrome P450 1B1 which has a very high degree of selectivity for P450 1B1 versus both P450 1A1 (>50-fold) and P450 1A2 (>520-fold). In vitro it inhibits cancer cell growth. ......by BOC Sciences
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000068489

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.
Store at RT by Tocris Bioscience Inc.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
Soluble to 25 mM in ethanol and to 100 mM in DMSO by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease
Target Cytochrome P450
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
TMS - Phase 3 Clinical
TMS - No Development Reported
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Safety Data of TMS

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC 5mg/USD60();10mg/USD96() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD96() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD96() China
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 24144-92-1

Name CAS No Formula MW

Recommended Compounds in Cytochrome P450

Name CAS No Formula MW
Dafadine-A 1065506-69-5 C23H25N3O3 391.46
VT-464 (racemate) 1375603-36-3 C18H17F4N3O3 399.34
VT-464 1610537-15-9 C18H17F4N3O3 399.34
Isosilybin 72581-71-6 C25H22O10 482.44
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Clarithromycin 81103-11-9 C38H69NO13 747.95
(+)-Ketoconazole 142128-59-4 C26H28Cl2N4O4 531.43
(+)-Ketoconazole 142128-59-4 C26H28Cl2N4O4 531.4309
Galangin 548-83-4
Bergapten 484-20-8 C12H8O4 216.19
Naringin 10236-47-2 C27H32O14 580.53
Diosmetin 520-34-3 C16H12O6 300.26
Fenofibrate 49562-28-9 C20H21ClO4 360.83
Bergaptol 486-60-2 C11H6O4 202.1629
Talarozole (R enantiomer) 870093-23-5 C21H23N5S 377.5058
Choline Fenofibrate 856676-23-8 C22H28ClNO5 421.91
Talarozole 201410-53-9 C21H23N5S 377.51
Isavuconazole 241479-67-4 C22H17F2N5OS 437.4650864
Cobicistat 1004316-88-4 C40H53N7O5S2 776.02
Methoxsalen 298-81-7 C12H8O4 216.19

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

TMS

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