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24144-92-1 (TMS)

1

Identification

TMS TMS
Name TMS
Formula C18H20O4
MW 300.35
CAS No. 24144-92-1
EINECS
Smiles COC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C(OC)=C1
Synonyms 2,4,3',5'-tetramethoxystilbene; (E)-1-(3,5-dimethoxystyryl)-2,4-dimethoxybenzene
InChI InChI=1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
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Introduction

Cancer Res. 2001 Nov 15;61(22):8164-70. J Med Chem. 2002 Jan 3;45(1):160-4. Breast Cancer Res Treat. 2011 Apr;126(3):779-89.

Background Information

TMS is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). It has strong selectivity among P450 family 1 enzymes. TMS exhibits 50-fold selectivity for P450 1B1 over P4501A1 and 500-fold selectivity for P450 1B1 over P450 1A2. IC50:6 nM[1] Target: P450 1B1(CYP1A1) in vitro: Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail). [3] in vivo: Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period ......by MedChemexpress Co., Ltd.
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC<sub>50</sub> = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth <em>in vitro</em>. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000068489

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.
Store at RT by Tocris Bioscience Inc.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
Soluble to 25 mM in ethanol and to 100 mM in DMSO by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease
Target Cytochrome P450
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
TMS - Phase 3 Clinical
TMS - No Development Reported
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Safety Data of TMS

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
CHEMSCENE, LLC USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 5mg/USD50(In stock);10mg/USD80(In stock);50mg/USD300(In stock);100mg/USD480(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Tocris Bioscience Inc. USA
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Related Products

Other Forms of 24144-92-1

Name CAS No Formula MW

Recommended Compounds in Cytochrome P450

Name CAS No Formula MW
Dafadine-A 1065506-69-5 C23H25N3O3 391.46
VT-464 (racemate) 1375603-36-3 C18H17F4N3O3 399.34
VT-464 1610537-15-9 C18H17F4N3O3 399.34
Isosilybin 72581-71-6 C25H22O10 482.44
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Clarithromycin 81103-11-9 C38H69NO13 747.95
(+)-Ketoconazole 142128-59-4 C26H28Cl2N4O4 531.43
Ketoconazole 65277-42-1 C26H28Cl2N4O4 531.43
Galangin 548-83-4
Bergapten 484-20-8 C12H8O4 216.19
Naringin 10236-47-2 C27H32O14 580.53
Diosmetin 520-34-3 C16H12O6 300.26
Fenofibrate 49562-28-9 C20H21ClO4 360.83
4-hydroxy-7H-furo[3,2-g]chromen-7-one 486-60-2 C11H6O4 202.16
(R)-Talarozole 870093-23-5 C21H23N5S 377.51
Choline Fenofibrate 856676-23-8 C22H28ClNO5 421.91
Talarozole 201410-53-9 C21H23N5S 377.51
BAL 4815 241479-67-4 C22H17F2N5OS 437.47
Cobicistat 1004316-88-4 C40H53N7O5S2 776.02
Methoxsalen 298-81-7 C12H8O4 216.19

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

TMS

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