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141136-83-6 (TRAP-6)

1

Identification

TRAP-6 TRAP-6
Name TRAP-6
Formula C34H56N10O9
MW 748.87
CAS No. 141136-83-6
EINECS
Smiles O=C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]](C(O)=O)CC(N)=O)=O)=O)=O)[[email protected]@H](NC([[email protected]@H](N)CO)=O)CC1=CC=CC=C1
Synonyms Ser-Phe-Leu-Leu-Arg-Asn;Thrombin Receptor Activator Peptide 6; (2S,5S,8S,11S,14S,17S)-17-amino-2-(2-amino-2-oxoethyl)-14-benzyl-5-(3-guanidinopropyl)-18-hydroxy-8,11-diisobutyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-1-oic acid
InChI InChI=1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
2

Introduction

TRAP-6 is protease-activated receptor 1 (PAR1) agonist. Target: PAR1 in vitro: TRAP-6 stimulates transient mobilization of free intracellular calcium, platelet aggregation (EC50 = 0.8μM) and rapidly phosphorylates PDE3A.

Background Information

TRAP-6, a peptide compound, has been found to be a PAR1 agonist and could also influence the phosphorylation of rapid phosphodiesterase 3A in the positive way. ......by BOC Sciences
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000066609

Storage condition

Solubility

DMSO: > 28 mg/mL by CHEMSCENE, LLC
DMSO: > 28 mg/mL by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Protease-Activated Receptor (PAR)
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
TRAP-6 - Not Found
TRAP-6 - No Development Reported
7

Safety Data of TRAP-6

WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
BOC Sciences
CHEMSCENE, LLC 5mg/USD144();10mg/USD240() USA
MedChemexpress Co., Ltd. 5mg/USD144();10mg/USD240() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD144();10mg/USD240() China
10

Related Products

Other Forms of 141136-83-6

Name CAS No Formula MW

Recommended Compounds in Protease-Activated Receptor (PAR)

Name CAS No Formula MW
AC-55541 916170-19-9 C25H20BrN5O3 518.362
Vorapaxar 618385-01-6 C29H33FN2O4 492.58
TFLLR-NH2 197794-83-5 C31H53N9O6 647.81
Protease-Activated Receptor-2, amide C28H54N8O7 614.8
Protease-Activated Receptor-4 C33H46N8O7 666.77
AZ3451 2100284-59-9 C30H27BrN4O3 571.46
AZ8838 2100285-41-2 C13H15FN2O 234.27
GB83 1252806-86-2 C32H44N4O4 548.72
GB88 1416435-96-5 C32H42N4O4 546.7
AY117 1357249-44-5 C30H42N4O4 522.68
SB89 2227508-24-7 C20H20FNO3 341.38
SB70 2227508-20-3 C20H20FNO3 341.38
AZ6343 C11H14N2O 190.24
AZ7188 31951-29-8 C17H14N2O 262.31
GB110 1252806-70-4 C33H48N6O5 608.77

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

TRAP-6

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