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148741-30-4 (Tyrphostin AG 879)

1

Identification

Tyrphostin AG 879 Tyrphostin AG 879
Name Tyrphostin AG 879
Formula C18H24N2OS
MW 316.46
CAS No. 148741-30-4
EINECS
Smiles OC1=C(C(C)(C)C)C=C(/C=C(C#N)/C(N)=S)C=C1C(C)(C)C
Synonyms (E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide; AG 879; (E)-2-cyano-3-(3,5-di-tert-butyl-4-hydroxyphenyl)prop-2-enethioamide
InChI InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
2

Introduction

Background Information

Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR. ......by BOC Sciences
Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR. ......by Selleck Chemicals LLC
Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Cell lines MCF-7 cells
Conditions 20 μM; 46 hours
Method Cells are grown in 96-well plates containing 100 μL medium per well. Ten microliters of MTT solution (5 mg/ml in PBS) is added to each well and incubation continued for 4 h at 37 °C. Subsequently, 100 μL 10% SDS in 0.01 M HCl is added. After incubation at 37°C overnight, absorption is measured at 550 nm in an ELISA reader using a reference filter of 690 nm.
Source Selleck Chemicals LLC

Animal Experiment

Animal Models nude mice carrying v-Ha-RAS transformed NIH 3T3 cells
Dosage 20 mg/kg
Formulation 30% dimethyl sulfoxide with PBS
Administration Intraperitoneally administrated on days 3, 5, 7, 10, 12, 14, and 17.
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance: EBNumber:EB000056792

Storage condition

Solubility

DMSO ≥ 36 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 36 mg/mL (113.75 mM); Ethanol3 mg/mL (9.47 mM); Water<1 mg/mL (<1 mM); In vivo 1% DMSO+30% polyethylene glycol+1% Tween 8030 mg/mL by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR Trk Receptor
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tyrphostin AG 879 - No Development Reported
7

Safety Data of Tyrphostin AG 879

WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Aladdin China
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD72();10mg/USD120() USA
Cayman Chemical Company 5mg/USD65();10mg/USD124();25mg/USD293();50mg/USD520() USA
EMD Millipore 5mg/USD129() USA
MedChemexpress Co., Ltd. 5mg/USD72();10mg/USD120() USA
Pure Chemistry Scientific Inc. 0//USDnull(In stock) USA
Santa Cruz Biotechnology, Inc. 5mg/USD83();25mg/USD328() USA
Selleck Chemicals LLC 5mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);10mg/USD110(In stock);25mg/USD270(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD72();10mg/USD120() China
Sigma-Aldrich, Inc. 5mg/USD112();25mg/USD448() USA
Target Molecule Corp. 5mg/USD24();10mg/USD45() USA
Tocris Bioscience Inc. 10mg/USD169() USA
Toronto Research Chemicals Inc. 5mg/USD50(Inquire);10mg/USD110();25mg/USD235();50mg/USD425();100mg/USD795() Canada
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Related Products

Other Forms of 148741-30-4

Name CAS No Formula MW

Recommended Compounds in EGFR Trk Receptor

Name CAS No Formula MW
Ginsenoside Rh2 78214-33-2 C36H62O8 622.87
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 445.56
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 595.71
Mutant EGFR inhibitor 1421373-62-7 C27H30ClN7O2 520.03
AZD-9291 1421373-65-0 C28H33N7O2 499.61
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 333.77
WHI-P180 211555-08-7 C16H15N3O3 297.31
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 483.36
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 489.54
BGB-102 807640-87-5 C22H25BrN4O2 457.36
Poziotinib 1092364-38-9 C23H21Cl2FN4O3 491.34
CO-1686 (hydrobromide) 1446700-26-0 C27H29BrF3N7O3 636.46
CO-1686 1374640-70-6 C27H28F3N7O3 555.55
CNX-2006 1375465-09-0 C26H27F4N7O2 545.53
PD168393 194423-15-9 C17H13BrN4O 369.2153
AG 18 118409-57-7 C10H6N2O2 186.17
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 718.08
Chrysophanol 481-74-3 C15H10O4 254.2375
AG-1478 153436-53-4 C16H14ClN3O2 315.75
Mubritinib 366017-09-6 C25H23F3N4O2 468.47

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

13

More Information

Tyrphostin AG 879

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