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2482-00-0 (Agmatine (sulfate))

1

Identification

Agmatine (sulfate) Agmatine (sulfate)
Name Agmatine (sulfate)
Formula C5H16N4O4S
MW 228.26994
CAS No. 2482-00-0
EINECS 219-617-3
Smiles NC(NCCCCN)=N.O=S(O)(O)=O
Synonyms NIH 11035
InChI InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
2

Introduction

Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.

Background Information

Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. ......by MedChemexpress Co., Ltd.
Agmatine Sulfate is a neurotransmitter and neuromodulator, inhibiting N-methyl-D-aspartate (NMDA), nicotinic acetylcholine receptors nitric oxide synthase, calcium channels and certain serotonin receptors, activating imidazoline receptors. ......by MedKoo Biosciences, Inc.
Agmatine sulfate is a bioactive metabolite of the arginine amino acid. It has been shown to increase nitric oxide, reduce blood sugar levels and even increase growth hormone levels. ......by Selleck Chemicals LLC
Arginine metabolite that is synthesized within bovine brain and exhibits clonidine-displacing substance (CDS) activity. Putative endogenous ligand for the imidazoline binding site. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:white to off-white EBNumber:EB000040009

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

10 mM in DMSO by MedChemexpress Co., Ltd.
Soluble to 100 mM in water by Tocris Bioscience Inc.
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation Neuronal Signaling GPCR/G Protein
Target Imidazoline Receptor NO Synthase
Research Area
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
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Safety Data of Agmatine (sulfate)

Safety Statements : S22;S24/25
WGKGermany : 3
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Spectral Information

9

Suppliers List

10

Related Products

Other Forms of 2482-00-0

Name CAS No Formula MW

Recommended Compounds in Imidazoline Receptor NO Synthase

Name CAS No Formula MW
Moxonidine (hydrochloride) 75536-04-8 C9H13Cl2N5O 278.14
Moxonidine 75438-57-2 C9H12ClN5O 241.68
Allantoin 97-59-6 C4H6N4O3 158.12
L-Arginine (hydrochloride) 1119-34-2 C6H15ClN4O2 210.66
L-Arginine 74-79-3 C6H14N4O2 174.2
6-Biopterin 22150-76-1 C9H11N5O3 237.22
4-Aminomethylbenzylalcohol 39895-56-2 C8H11NO 137.179
AVE-3085 450348-85-3 C17H13F2NO3 317.29
Kuwanon A 62949-77-3 C25H24O6 420.45
L-NAME (hydrochloride) 51298-62-5 C7H16ClN5O4 269.686
1400W (Dihydrochloride) 214358-33-5 C10H17Cl2N3 250.1681
Tetrahydrobiopterin 17528-72-2 C9H15N5O3 241.2471
iNOS-IN-1 C13H22Cl2N4O 321.25
iNOS-IN-2 C16H28Cl2N4O 363.33
iNOS-IN-3 C16H28Cl2N4O 363.33
iNOS-IN-4 C16H30Cl3N7O 442.81
iNOS-IN-5 C16H25Cl3N6O 423.77
iNOS-IN-6 C16H30Cl3N5O 414.8
iNOS-IN-7 C14H22Cl2N4O3 365.26
iNOS-IN-8 C15H24Cl2N4O3 379.28

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

Protocol Reference

Merck Index 12 186.

Li et al (1994) Agmatine: an endogenous clonidine-displacing substance in the brain. 263 966. PMID: 7906055.

Piletz et al (1995) Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2-adrenergic receptors. J.Pharmacol.Exp.Ther. 272 581. PMID: 7853171.

Reis and Regunathan (2000) Is agmatine a novel neurotransmitter in brain? TiPs 21 187. PMID: 1 ......by Tocris Bioscience Inc.

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More Information

Agmatine (sulfate)

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