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1405-20-5 (Polymyxin B sulfate)

1

Identification

Polymyxin B sulfate Polymyxin B sulfate
Name Polymyxin B sulfate
Formula C56H100N16O17S
MW 1301.56
CAS No. 1405-20-5
EINECS 215-774-7
Smiles CCC(C)CCCCC(NC(C(NC(C(NC(C(NC1C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C(NC(CCN)C(NC(CCN)C(NC(C(O)C)C(NCC1)=O)=O)=O)=O)=O)=O)=O)=O)CCN)=O)C(O)C)=O)CCN)=O.O=S(O)(O)=O
Synonyms N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamo; N-(4-amino-1-((1-((4-amino-1-oxo-1-((6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide sulfate
InChI InChI=1S/C56H98N16O13.H2O4S/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79;1-5(2,3)4/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80);(H2,1,2,3,4)
2

Introduction

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components.

Background Information

Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane. ......by AdooQ BioScience, LLC
Polymyxin B sulfate is obtained from Bacillus polymyxa and related species as a mixture of polymyxins B1 and B2. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B (sulfate) is a mixtur ......by BOC Sciences
Polymyxin B sulfate is a polypeptide antibiotic and is composed of polymyxins B1, B2, and B3 with fractions B1 and B2 comprising the majority of the mixture. Polymyxin B targets and alters permeability lipopolysaccharide (LPS) of gram negative bacteria leading to lysing of the cell. Polymyxin B only needs to interact with LPS, it is not required to enter the cell. Polymyxin B is routinely used as a selection agent in several types of isolation media. ......by BioVision, Inc.,
Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 (Item No. 14074) and B2 being the two major components. ......by MedKoo Biosciences, Inc.
Polymyxin B sulphate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000037789

Storage condition

Solubility

H<sub>2</sub>O by CHEMSCENE, LLC
H2O by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Anti-infection
Target Bacterial
Research Area Others
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Polymyxin B sulfate - Discovery
Polymyxin B sulfate - Launched
7

Safety Data of Polymyxin B sulfate

´╗┐Hazard Symbols : Xn
´╗┐Risk Statements : 22
Safety Statements : 22-24/25
RTECS : TR1150000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Abcam 250mg/USD55();1g/USD119();5g/USD539() USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BIOLOGOS, INC. USA
BOC Sciences
BioVision, Inc., USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 500mg/USD60();1g/USD72() USA
Cayman Chemical Company 500mg/USD35();1g/USD53();5g/USD175() USA
China Jintai Biocompound Company China
Hangzhou Holypharm Biotech Co., Ltd. China
MedChemexpress Co., Ltd. 500mg/USD60();1g/USD72() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 500mg/USD56() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 500mg/USD60();1g/USD72() China
Sigma-Aldrich, Inc. 25mg/USD163() USA
Sinoway Industrial Co., Ltd. China
Taizhou Crene Biotechnology Co., Ltd. China
Target Molecule Corp. 10mg/USD20();50mg/USD78();100mg/USD140() USA
Toronto Research Chemicals Inc. 500mg/USD45();1g/USD50();5g/USD160();10g/USD245();25g/USD450() Canada
Xingcheng Chempharm Co., Ltd. China
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Related Products

Other Forms of 1405-20-5

Name CAS No Formula MW
Polymyxin B2 34503-87-2 C55H96N16O13 1189.45
Polymyxin B1 4135-11-9 C56H98N16O13 1203.48

Recommended Compounds in Bacterial

Name CAS No Formula MW
Fidaxomicin 873857-62-6 C52H74Cl2O18 1058.04
AVX 13616 900814-48-4 C50H73Cl2N7O7 955.06
Bedaquiline (fumarate) 845533-86-0 C36H35BrN2O6 671.58
Mafenide (Acetate) 13009-99-9 C9H14N2O4S 246.28
Cefozopran 113359-04-9 C19H17N9O5S2 515.53
Azithromycin 83905-01-5 C38H72N2O12 748.9845
Pazufloxacin 127045-41-4 C16H15FN2O4 318.3
Pazufloxacin (mesylate) 163680-77-1 C17H19FN2O7S 414.4054
Capreomycin (sulfate) 1405-37-4 C24H44N14O12S 752.76
Bleomycin (sulfate) 9041-93-4 C110H168N34O46S7 2927.17
G-418 (disulfate) 108321-42-2 C20H44N4O18S2 692.71
Demeclocycline (hydrochloride) 64-73-3 C21H22Cl2N2O8 501.31
Apramycin 37321-09-8 C21H41N5O11 539.58
Ceftriaxone 73384-59-5 C18H18N8O7S3 554.58
Ceftibuten 97519-39-6 C15H14N4O6S2 410.42
Dapsone 80-08-0 C12H12N2O2S 248.3
Vancomycin 1404-90-6 C66H76Cl3N9O24 1485.72
Lomefloxacin 98079-51-7 C17H19F2N3O3 351.35
Dirithromycin 62013-04-1 C42H78N2O14 835.07
Cefepime (Dihydrochloride Monohydrate) 123171-59-5 C19H28Cl2N6O6S2 571.5

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Polymyxin B sulfate

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