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1200-22-2 (Lipoic acid)

1

Identification

Lipoic acid Lipoic acid
Name Lipoic acid
Formula C8H14O2S2
MW 206.3256
CAS No. 1200-22-2
EINECS
Smiles O=C(O)CCCC[[email protected]]1SSCC1
Synonyms (R)-(+)-α-Lipoic acid;alpha-Lipoic acid;R-(+)-Thioctic acid
InChI InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
2

Introduction

Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

Background Information

Lipoic Acid, an organosulfur compound, is widely used as dietary supplements and antioxidant. It has been also found to influence the activity of nuclear factor kappa-B. ......by BOC Sciences
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid. ......by MedChemexpress Co., Ltd.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000037468

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Lipoic acid Oregon State University Atherosclerosis 2008/10/1 2015/6/1 Phase 3 Clinical
Lipoic acid VA Office of Research and Development Multiple Sclerosis, Chronic Progressive 2010/8/25 2015/7/1 Phase 3 Clinical
Lipoic acid Wuhan General Hospital of Guangzhou Military Command Type 2 Diabetes Coronary Artery Disease Left Ventricular Mass 2013/6/11 2015/8/1 Phase 3 Clinical
Lipoic acid Universidad Popular Autónoma del Estado de Puebla Diabetic Neuropathy 2015/5/4 2015/5/1 Phase 3 Clinical
Lipoic acid - Phase 4
7

Safety Data of Lipoic acid

WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Aladdin 5g/RMB596();25g/RMB1099();100g/RMB3299() China
Alfa Chemistry USA
BOC Sciences
CHEMSCENE, LLC 500mg/USD72() USA
Carbosynth Limited 10g/USD45();25g/USD75();50g/USD125();100g/USD200();250g/USD305()
Changshu Fushilai Medicine & Chemical Co., Ltd. China
Changzhou Kangzheng Pharmachem Technology Co., Ltd. China
Dibo Chemicals 5g/RMB366();25g/RMB915() China
MAYA-R 5g/RMB300();25g/RMB600();100g/RMB1200() China
MedChemexpress Co., Ltd. 500mg/USD72() USA
Nanjing Elegant Nutraceuticals Co., Ltd. China
Santa Cruz Biotechnology, Inc. 5g/USD250() USA
Shaanxi Pioneer Biotech Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 500mg/USD72() China
Shanghai Pharmarketech Co., Ltd. China
Sigma-Aldrich, Inc. 1g/USD162() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 1g/RMB199();5g/RMB439();25g/RMB989() China
Tokyo Chemical Industry Co., Ltd. 5g/USD77();25g/USD229();100g/USD658() Japan
Toronto Research Chemicals Inc. 50mg/USD45();500mg/USD65();5g/USD75();25g/USD225();50g/USD435();100g/USD650() Canada
10

Related Products

Other Forms of 1200-22-2

Name CAS No Formula MW

Recommended Compounds in NF-κB

Name CAS No Formula MW
RTA-408 1474034-05-3 C33H44F2N2O3 554.7108664
Protopanaxatriol 1453-93-6 C30H52O4 476.73
8-O-Acetyl shanzhiside methyl ester 57420-46-9 C19H28O12 448.42
Berbamine (dihydrochloride) 6078-17-7 C37H42Cl2N2O6 681.6452
Neochlorogenic acid 906-33-2 C16H18O9 354.31
Schisantherin A 58546-56-8 C30H32O9 536.57
Schizandrin A 61281-38-7 C22H28O6 388.45
Prim-O-glucosylcimifugin 80681-45-4 C22H28O11 468.45
Maslinic acid 4373-41-5 C30H48O4 472.7
Morusin 62596-29-6 C25H24O6 420.45
Ginsenoside Rg2 52286-74-5 C42H72O13 785.01
Ginsenoside Rf 52286-58-5 C42H72O14 801.01
Ginsenoside F1 53963-43-2 C36H62O9 638.87
Genistin 529-59-9 C21H20O10 432.38
Methylthiouracil 56-04-2 C5H6N2OS 142.18
Erdosteine 84611-23-4 C8H11NO4S2 249.31
Sodium Salicylate 54-21-7 C7H5NaO3 160.1
JSH-23 749886-87-1 C16H20N2 240.34
Neferine 2292-16-2 C38H44N2O6 624.77
Cucurbitacin E 18444-66-1 C32H44O8 556.69

Recommended Compounds in Same Indication

Name CAS No Formula MW
LXR-623 875787-07-8 C21H12ClF5N2 422.78
Cebranopadol 863513-91-1 C24H27FN2O 378.48
(Z)-Olesoxime 66514-00-9 C27H45NO 399.6523
ADL-5859 850173-95-4 C24H29ClN2O3 428.95
Laropiprant 571170-77-9 C21H19ClFNO4S 435.9
Darapladib 356057-34-6 C36H38F4N4O2S 666.77
SCH 530348 sulfate 705260-08-8 C29H35FN2O8S 590.66
Ranirestat 147254-64-6 C17H11BrFN3O4 420.19
RVX-208 1044870-39-4 C20H22N2O5 370.4
Clopidogrel (hydrogen sulfate) 120202-66-6 C16H18ClNO6S2 419.9002
Fluvastatin 93957-54-1 C24H26FNO4 411.47
11

Route of Synthesis

12

References

13

More Information

Lipoic acid

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