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134-63-4 (Lobeline (hydrochloride))

1

Identification

Lobeline (hydrochloride) Lobeline (hydrochloride)
Name Lobeline (hydrochloride)
Formula C22H28ClNO2
MW 373.9162
CAS No. 134-63-4
EINECS 205-150-2
Smiles CN1[[email protected]@H](CC(C2=CC=CC=C2)=O)CCC[[email protected]]1C[[email protected]](O)C3=CC=CC=C3.[H]Cl
Synonyms α-Lobeline hydrochloride;L-Lobeline hydrochloride
InChI InChI=1S/C22H27NO2.ClH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-21,24H,8,13-16H2,1H3;1H/t19-,20+,21-;/m0./s1
2

Introduction

VMAT2 ligand, stimulating dopamine release, inhibiting the reuptake of dopamine and serotonin, acting as a mixed agonist-antagonist at nicotinic acetylcholine receptors and antagonist at µ-opioid receptors

Background Information

VMAT2 ligand, stimulating dopamine release, inhibiting the reuptake of dopamine and serotonin, acting as a mixed agonist-antagonist at nicotinic acetylcholine receptors and antagonist at µ-opioid receptors ......by AOBIOUS INC
α-Lobeline Hydrochcloride is a neuronal nicotinic acetylcholine receptor agonist. It is also a CNS stimulant. ......by BOC Sciences
Lobeline hydrochloride is a VMAT2 ligand, stimulating dopamine release, inhibiting the reuptake of dopamine and serotonin, acting as a mixed agonist-antagonist at nicotinic acetylcholine receptors and antagonist at µ-opioid receptors. ......by MedKoo Biosciences, Inc.
An alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation. ......by Target Molecule Corp.
High affinity, partial agonist with a Ki value of 4.4 nM in rat brain. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:white to off-white EBNumber:EB000031839

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

10 mM in H2O by CHEMSCENE, LLC
10 mM in H2O by MedChemexpress Co., Ltd.
Soluble to 50 mM in ethanol and to 10 mM in water by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel Neuronal Signaling
Target nAChR
Research Area Neurological Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Lobeline (hydrochloride) - Launched
7

Safety Data of Lobeline (hydrochloride)

Hazard Symbols : T
Risk Statements : R23/25
Safety Statements : S36/37/39;S45
Transport Information : UN 1544
RTECS : OJ8490100
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AOBIOUS INC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Element Chem-tech Company CHINA
Beijing Infoark Technology Development Co., Ltd. China
CHEMSCENE, LLC 100mg/USD60();500mg/USD84() USA
Clearsynth Labs Limited 25mg/USD100();50mg/USD150() India
MAYA-R 1g/RMB952() China
MedChemexpress Co., Ltd. 100mg/USD60();500mg/USD84() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 50mg/USD20();1g/USD106() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();500mg/USD84() China
Sigma-Aldrich, Inc. 1g/USD88() USA
Target Molecule Corp. 2mg/USD20();10mg/USD74();50mg/USD125() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 1g/RMB1879() China
Tocris Bioscience Inc. USA
Tokyo Chemical Industry Co., Ltd. 1g/USD85() Japan
Toronto Research Chemicals Inc. 100mg/USD45();250mg/USD55();500mg/USD70();1g/USD95();2g/USD165();5g/USD295() Canada
10

Related Products

Other Forms of 134-63-4

Name CAS No Formula MW

Recommended Compounds in nAChR

Name CAS No Formula MW
L-Nicotine 54-11-5 C10H14N2 162.23
Decamethonium (Bromide) 541-22-0 C16H38Br2N2 418.29
Hexamethonium (Bromide) 55-97-0 C12H30Br2N2 362.19
Meclofenoxate (hydrochloride) 3685-84-5 C12H17Cl2NO3 294.17
Pancuronium (dibromide) 15500-66-0 C35H60Br2N2O4 732.67
Adiphenine (hydrochloride) 50-42-0 C20H26ClNO2 347.88
Atracurium (besylate) 64228-81-5 0.0
Vecuronium (bromide) 50700-72-6 C34H57BrN2O4 637.73
Catharanthine 2468-21-5 C21H24N2O2 336.43
Vinblastine 865-21-4 C46H58N4O9 810.97
Cisatracurium (besylate) 96946-42-8 C65H82N2O18S2 1243.48
EVP-6124 (hydrochloride) 550999-74-1 C16H18Cl2N2OS 357.3
EVP-6124 550999-75-2 C16H17ClN2OS 320.84
ABT 894 799279-80-4 C10H11Cl2N3 244.12
Monepantel 887148-69-8 C20H13F6N3O2S 473.39
GTS-21 148372-04-7 C19H20N2O2 308.37
ZSET1446 887603-94-3 C15H12N2O 236.2686
Aniracetam 72432-10-1 C12H13NO3 219.24
CP-810123 439608-12-5 C14H18N4O 258.32
Varenicline (Tartrate) 375815-87-5 C17H19N3O6 361.35

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

Protocol Reference

Merck Index 12 5580.

Damaj et al (1997) Pharmacology of lobeline, a nicotinic receptor ligand. J.Pharmacol.Exp.Ther. 282 410. PMID: 9223582.

Farook et al (2009) Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice. Physiol.Behav. 97 503. PMID: PMID: 19268674.

......by Tocris Bioscience Inc.
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More Information

Lobeline (hydrochloride)

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