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95-25-0 (Chlorzoxazone)

1

Identification

Chlorzoxazone Chlorzoxazone
Name Chlorzoxazone
Formula C7H4ClNO2
MW 169.57
CAS No. 95-25-0
EINECS 202-403-9
Smiles O=C1OC(C=CC(Cl)=C2)=C2N1
Synonyms 5-Chloro-2(3H)-benzoxazolone; 5-Chloro-2-benzoxazolone; 5-chlorobenzo[d]oxazol-2(3H)-one
InChI InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
2

Introduction

Background Information

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans. ......by MedChemexpress Co., Ltd.
Chlorzoxazone is a benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown, chlorzoxazone (CZ) appears to act at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000030348

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

34 mg/mL in DMSO by CHEMSCENE, LLC
34 mg/mL in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease
Target Cytochrome P450
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Chlorzoxazone - Launched
7

Safety Data of Chlorzoxazone

Hazard Symbols : Xi
Risk Statements : R36/37/38
Safety Statements : S24/25
RTECS : DM5250000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Aceto Corporation USA
Acros Organics 25g/USD56();100g/USD87() Belgium
Aladdin 25g/RMB493();250g/RMB2610() China
Bide Pharmatech Ltd. 10g/USD50() China
CHEMSCENE, LLC USA
Changzhou Hangyu Pharmaceutical Technology Co., Ltd. China
Jai Radhe Sales India
Matrix Scientific 100g/USD41() USA
MedChemexpress Co., Ltd. 5g/USD50(In stock) USA
Santa Cruz Biotechnology, Inc. 10mg/USD20() USA
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Sigma-Aldrich, Inc. 25g/USD64();100g/USD215() USA
Spectrum Chemical Mfg. Corp. 5g/USD49();25g/USD96();100g/USD224() USA
Target Molecule Corp. 5mg/USD20();25mg/USD71();50mg/USD132();100mg/USD245() USA
Tianjin Heowns Biochemical Technology Co., Ltd. 5g/RMB331() China
Tokyo Chemical Industry Co., Ltd. 25g/USD76();250g/USD402() Japan
Toronto Research Chemicals Inc. 10mg/USD40();1g/USD45();10g/USD55();25g/USD65();50g/USD115();100g/USD200() Canada
Wuxi Dayang Chemical Co., Ltd. China
10

Related Products

Other Forms of 95-25-0

Name CAS No Formula MW

Recommended Compounds in Cytochrome P450

Name CAS No Formula MW
Dafadine-A 1065506-69-5 C23H25N3O3 391.46
VT-464 (racemate) 1375603-36-3 C18H17F4N3O3 399.34
VT-464 1610537-15-9 C18H17F4N3O3 399.34
Isosilybin 72581-71-6 C25H22O10 482.44
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Clarithromycin 81103-11-9 C38H69NO13 747.95
(+)-Ketoconazole 142128-59-4 C26H28Cl2N4O4 531.43
Ketoconazole 65277-42-1 C26H28Cl2N4O4 531.43
Galangin 548-83-4
Bergapten 484-20-8 C12H8O4 216.19
Naringin 10236-47-2 C27H32O14 580.53
Diosmetin 520-34-3 C16H12O6 300.26
Fenofibrate 49562-28-9 C20H21ClO4 360.83
4-hydroxy-7H-furo[3,2-g]chromen-7-one 486-60-2 C11H6O4 202.16
(R)-Talarozole 870093-23-5 C21H23N5S 377.51
Choline Fenofibrate 856676-23-8 C22H28ClNO5 421.91
Talarozole 201410-53-9 C21H23N5S 377.51
BAL 4815 241479-67-4 C22H17F2N5OS 437.47
Cobicistat 1004316-88-4 C40H53N7O5S2 776.02
Methoxsalen 298-81-7 C12H8O4 216.19

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Chlorzoxazone

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