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54-36-4 (Metyrapone)

1

Identification

Metyrapone Metyrapone
Name Metyrapone
Formula C14H14N2O
MW 226.27
CAS No. 54-36-4
EINECS 200-206-2
Smiles O=C(C(C)(C)C1=CC=CN=C1)C2=CC=CN=C2
Synonyms 2-methyl-1,2-di(pyridin-3-yl)propan-1-one
InChI InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
2

Introduction

Background Information

Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1. Target: CYP11B1 Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-Deoxycortisol levels. ......by MedChemexpress Co., Ltd.
An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000029249

Storage condition

Solubility

10 mM in DMSO by CHEMSCENE, LLC
10 mM in DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Metabolic Enzyme/Protease Autophagy
Target Autophagy Cytochrome P450
Research Area Metabolic Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Metyrapone - Launched
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Safety Data of Metyrapone

Hazard Symbols : Xn
Risk Statements : 22-36/37/38
Safety Statements : 26
RTECS : UC3050000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC 100mg/USD40();250mg/USD80();500mg/USD140();1g/USD220() USA
Biomol GmbH Germany
CHEMSCENE, LLC USA
Cayman Chemical Company 250mg/USD17();500mg/USD29();1g/USD44() USA
Enzo Life Sciences International Inc. 200mg/USD32() USA
MedChemexpress Co., Ltd. 500mg/USD50(In stock) USA
Santa Cruz Biotechnology, Inc. 200mg/USD20() USA
Shanghai Haoyuan Chemexpress Co., Ltd. China
Sigma-Aldrich, Inc. 10mg/USD94();50mg/USD372() USA
Target Molecule Corp. 2mg/USD20();10mg/USD63();50mg/USD145();100mg/USD211() USA
Tocris Bioscience Inc. 50mg/USD75() USA
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Related Products

Other Forms of 54-36-4

Name CAS No Formula MW

Recommended Compounds in Autophagy Cytochrome P450

Name CAS No Formula MW
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 664.1
Berberine (chloride hydrate) 141433-60-5 C20H18ClNO4 371.81
DMH-1 1206711-16-1 C24H20N4O 380.44
CB-839 1439399-58-2 C26H24F3N7O3S 571.57
H 89 (hydrochloride) 130964-39-5 C20H22BrCl2N3O2S 519.28
Shikonin 517-89-5 C16H16O5 288.3
H 89 127243-85-0 C20H20BrN3O2S 446.36
Eupatilin 22368-21-4 C18H16O7 344.32
Isoalantolactone 470-17-7 C15H20O2 232.32
Scutellarein 529-53-3 C15H10O6 286.24
Leonurine 24697-74-3 C14H21N3O5 311.33
Berbamine (hydrochloride) 6078-17-7 C37H42Cl2N2O6 681.65
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 306.37
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 215.63
Schizandrin A 61281-38-7 C22H28O6 388.45
Schisandrol B 58546-54-6 C23H28O7 416.46
Schisandrol A 7432-28-2 C24H32O7 432.51
Anhydroicaritin 118525-40-9 C21H20O6 368.38
Bicyclol 118159-48-1 C19H18O9 390.34
Azithromycin (hydrate) 117772-70-0 C38H72N2O12 748.98

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

Protocol Reference

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More Information

Metyrapone

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