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1190378-57-4 (MRT67307)

1

Identification

MRT67307 MRT67307
Name MRT67307
Formula C26H36N6O2
MW 464.6
CAS No. 1190378-57-4
EINECS
Smiles O=C(NCCCNC1=NC(NC2=CC=CC(CN3CCOCC3)=C2)=NC=C1C4CC4)C5CCC5
Synonyms MRT 67307;MRT-67307; N-(3-((5-cyclopropyl-2-((3-(morpholinomethyl)phenyl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide
InChI InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)
2

Introduction

MRT67307 is a dual inhibitor of the IKKe and TBK-1.

Background Information

MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. ......by AdooQ BioScience, LLC
Description ......by Apexbio Technology LLC
This active molecular is a potent ULK1/2 inhibitor and the IC50 value is 2.9 nM and 1.1 nM. MRT68921 is also a SIK inhibitor. ......by BOC Sciences
MRT67307 is a dual inhibitor of the IKKe and TBK-1 ......by BioVision, Inc.,
MRT67307 is a dual inhibitor of the IKKε and TBK-1, which mediates the phosphorylation of interferon regulatory factor 3 (IRF3), with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, and also targets ULK1 and ULK2 with high potency (IC50 values of 45 and 38 nM, respectively). ......by MedChemexpress Co., Ltd.
MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells; the autophagy-inhibiting capacity of MRT67307 is specifically through ULK1, results in accumulation of stalled early autophagosomal structures in treated cells; increases IL-10 production and suppresses proinflammatory cytokine production in macrophages, increases CREB-dependent gene transcription by promoting the dephosphorylation of CRTC3; also inhibits MARK, NUAK and SIK isoforms in vitro with comparable potency to the IKK-related kinases. ......by ProbeChem
MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. ......by Selleck Chemicals LLC
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow solid EBNumber:EB000028917

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways NF-κB Autophagy
Target IKK Autophagy
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
MRT67307 - Not Found
MRT67307 - No Development Reported
7

Safety Data of MRT67307

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
BioVision, Inc., USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD96();10mg/USD156() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 5mg/USD96();10mg/USD156() USA
ProbeChem
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD96();10mg/USD156() China
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Related Products

Other Forms of 1190378-57-4

Name CAS No Formula MW

Recommended Compounds in IKK Autophagy

Name CAS No Formula MW
Amlexanox 68302-57-8 C16H14N2O4 298.29
SC-514 354812-17-2 C9H8N2OS2 224.3
IKK 16 873225-46-8 C28H29N5OS 483.63
Icariin 489-32-7 C33H40O15 676.66
Resveratrol 501-36-0 C14H12O3 228.24
PS-1145 431898-65-6 C17H11ClN4O 322.7484
MLN120B 783348-36-7 C19H15ClN4O2 366.8
Bay 65-1942 (R form) 758683-21-5 C22H25N3O4 395.45
Apigenin 520-36-5 C15H10O5 270.2369
BI605906 960293-88-3 C17H22F2N4O3S2 432.51
BMS-345541 (free base) 445430-58-0 C14H17N5 255.32
IMD-0354 978-62-1 C15H8ClF6NO2 383.67
Bay 65-1942 (free base) 600734-02-9 C22H25N3O4 395.45
Bay 65-1942 (hydrochloride) 600734-06-3 C22H26ClN3O4 431.91
ACHP (Hydrochloride) 406209-26-5 C21H25ClN4O2 400.9018
IKK-3 Inhibitor 862812-98-4 C22H19N3O5S2 469.53
BMS-345541 547757-23-3 C14H18ClN5 291.78
TPCA-1 507475-17-4 C12H10FN3O2S 279.29
AZD3264 1609281-86-8 C21H23N5O4S 441.5
LY2409881 (trihydrochloride) 946518-60-1 C24H32Cl4N6OS 594.43

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

MRT67307

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