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54573-75-0 (Doxercalciferol)

1

Identification

Doxercalciferol Doxercalciferol
Name Doxercalciferol
Formula C28H44O2
MW 412.65
CAS No. 54573-75-0
EINECS
Smiles C=C1[[email protected]](C[[email protected]@H](C/C1=C/C=C2[[email protected]]3([[email protected]@](C)([[email protected]](CC3)[[email protected]@H](/C=C/[[email protected]@H](C(C)C)C)C)CCC/2)[H])O)O
Synonyms Hectorol; 1.alpha.-Hydroxyvitamin D2; (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
InChI InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1
2

Introduction

Doxercalciferol (Hectorol; 1.alpha.-Hydroxyvitamin D2) is a synthetic analog of vitamin D; is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

Background Information

Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA). ......by Affix Scientific
One of the analog of Vitamin D2, which could be effective as an antirachitic agent. ......by BOC Sciences
Doxercalciferol (Hectorol; 1.alpha.-Hydroxyvitamin D2) is a synthetic analog of vitamin D; is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA). ......by MedChemexpress Co., Ltd.
Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. ......by Selleck Chemicals LLC
Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000028771

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 83 mg/mL (201.13 mM); Ethanol70 mg/mL (169.63 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Doxercalciferol University of California Los Angeles Renal osteodystrophy 2009/3/31 2014/6/30 Phase 4 Clinical
Doxercalciferol University of California Los Angeles Bone disease 2009/3/31 2014/6/30 Phase 4 Clinical
Doxercalciferol Emory University Secondary hyperparathyroidism 2008/4/30 2010/6/30 Phase 4 Clinical
Doxercalciferol Genzyme Corp Secondary hyperparathyroidism 2006/11/30 2007/7/31 Phase 4 Clinical
Doxercalciferol Genzyme Corp Secondary hyperparathyroidism 2007/4/30 2007/12/31 Phase 4 Clinical
Doxercalciferol - Launched
7

Safety Data of Doxercalciferol

Hazard Symbols : T+
Risk Statements : 28
Safety Statements : 28-36/37-45
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Affix Scientific USA
BOC Sciences
CHEMSCENE, LLC 10mg/USD120(In stock);50mg/USD500(In stock);100mg/USD900(In stock) USA
Hydragon Pharma Co., Ltd. China
MedChemexpress Co., Ltd. 2mg/USD50(In stock);5mg/USD80(In stock);10mg/USD120(In stock);25mg/USD270(In stock);50mg/USD500(In stock);100mg/USD900(In stock) USA
Selleck Chemicals LLC 1mg/USD70(In stock);5mg/USD270(In stock);10mM/1mLIn DMSO/USD430(In stock) USA
Shanghai Everchem Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. China
Target Molecule Corp. 5mg/USD98();10mg/USD152();25mg/USD265();50mg/USD415() USA
10

Related Products

Other Forms of 54573-75-0

Name CAS No Formula MW

Recommended Compounds in VD/VDR

Name CAS No Formula MW
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 416.64
(24R)-MC 976 112828-09-8 C27H42O3 414.62
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 416.64
Impurity D of Calcitriol 103656-40-2 C28H46O3 430.66
Calcifediol (monohydrate) 63283-36-3 C27H44O2 400.64
Cholecalciferol 67-97-0 C27H44O 384.64
(24S)-MC 976 112849-14-6 C27H42O3 414.62
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol 112875-61-3 C39H68O3Si2 641.13
VD3-D6 118584-54-6 C27H38D6O 390.67
VD2-D3 1217448-46-8 C28H41D3O 399.67
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 418.68
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 434.68
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 430.62
Vitamin D4 511-28-4 C27H44O 384.64
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 73837-24-8 C27H44O3 416.64
(1R,3S,E)-5-((E)-2-((1R,3aR,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 113082-99-8 C27H40O3 412.6
Paricalcitol 131918-61-1 C27H44O3 416.64
MC 976 129831-99-8 C27H42O3 414.62
24R-Calcipotriol 112827-99-3 C27H40O3 412.6
MC 1046 126860-83-1 C27H38O3 410.59

Recommended Compounds in Same Indication

Name CAS No Formula MW
Alfacalcidol 41294-56-8 C27H44O2 400.64
Cinacalcet (hydrochloride) 364782-34-3 C22H23ClF3N 393.87
Cinacalcet 226256-56-0 C22H22F3N 357.41
Paricalcitol 131918-61-1 C27H44O3 416.64
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Route of Synthesis

12

References

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More Information

Doxercalciferol

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