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177036-94-1 (Ambrisentan)

1

Identification

Ambrisentan Ambrisentan
Name Ambrisentan
Formula C22H22N2O4
MW 378.42
CAS No. 177036-94-1
EINECS
Smiles O=C(O)C(OC1=NC(C)=CC(C)=N1)C(C2=CC=CC=C2)(OC)C3=CC=CC=C3
Synonyms 2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid; 2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid
InChI InChI=1S/C22H22N2O4/c1-15-14-16(2)24-21(23-15)28-19(20(25)26)22(27-3,17-10-6-4-7-11-17)18-12-8-5-9-13-18/h4-14,19H,1-3H3,(H,25,26)
2

Introduction

Ambrisentan(BSF 208075; LU 208075) is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor.

Background Information

Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH). ......by BOC Sciences
Ambrisentan is a selective ET type A receptor (ETAR) antagonist. ......by MedChemexpress Co., Ltd.
Ambrisentan is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH). ......by Selleck Chemicals LLC
Ambrisentan is an Endothelin Receptor Antagonist. The mechanism of action of ambrisentan is as an Endothelin Receptor Antagonist. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028719

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 76 mg/mL (200.83 mM); Ethanol22 mg/mL (58.13 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ambrisentan Washington University in St Louis Congenital heart defect 2012/8/31 2015/1/31 Phase 4 Clinical
Ambrisentan University of Alabama at Birmingham Pulmonary hypertension 2011/5/31 2013/7/31 Phase 4 Clinical
Ambrisentan University of California Los Angeles Pulmonary hypertension 2009/3/31 2010/12/31 Phase 4 Clinical
Ambrisentan University of California Los Angeles Scleroderma 2009/3/31 2010/12/31 Phase 4 Clinical
Ambrisentan University of Texas Southwestern Medical Center Cardiac failure 2009/1/31 2012/6/30 Phase 4 Clinical
Ambrisentan University of Texas Southwestern Medical Center Pulmonary hypertension 2009/1/31 2012/6/30 Phase 4 Clinical
Ambrisentan - Launched
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Safety Data of Ambrisentan

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Beijing Hony Biopharma Technology Co., Ltd. China
Beijing Mesochem Technology Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD60();10mg/USD72() USA
MedChemexpress Co., Ltd. 5mg/USD60();10mg/USD72() USA
Selleck Chemicals LLC 10mg/USD170(In stock);10mM/1mLIn DMSO/USD220(In stock);50mg/USD570(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD60();10mg/USD72() China
Shanghai Longschem Co., Ltd. China
Shanghai Taiheng Industry Co., Ltd. China
Shanghai Tingychem Co., Ltd. China
Target Molecule Corp. 5mg/USD48();10mg/USD82();25mg/USD133() USA
10

Related Products

Other Forms of 177036-94-1

Name CAS No Formula MW

Recommended Compounds in Endothelin Receptor

Name CAS No Formula MW
ACT-132577 1103522-45-7 C16H14Br2N6O4S 546.19
BQ-788 (sodium salt) 156161-89-6 C34H50N5NaO7 663.78
Sulfisoxazole 127-69-5 C11H13N3O3S 267.3
Atrasentan (hydrochloride) 195733-43-8 C29H39ClN2O6 547.08
Bosentan (hydrate) 157212-55-0 C27H31N5O7S 569.63
SPI-1620 142569-99-1 C83H112N19O25 1775.89
Atrasentan 173937-91-2 C29H38N2O6 510.62
Sitaxsentan (phosphate) 215501-46-5 C18H17ClN2O10PS2- 551.8923
Macitentan 441798-33-0 C19H20Br2N6O4S 588.27
Avosentan 290815-26-8 C23H21N5O5S 479.51
Zibotentan 186497-07-4 C19H16N6O4S 424.43
sitaxsentan 184036-34-8 C18H15ClN2O6S2 454.9
Bosentan 147536-97-8 C27H29N5O6S 551.61
Sitaxsentan (sodium) 210421-74-2 C18H14ClN2NaO6S2 476.89
Endothelin 1 117399-94-7 C109H159N25O32S5 2491.9
BQ-123 136553-81-6 C31H42N6O7 610.7012
Aminaftone 14748-94-8 C18H15NO4 309.32
Ro 46-2005 150725-87-4 C23H27N3O6S 473.54
ZD-1611 186497-38-1 C22H24N4O5S 456.51
Macitentan (n-butyl analogue) 556797-16-1 C20H21Br2N5O4S 587.28

Recommended Compounds in Same Indication

Name CAS No Formula MW
sitaxsentan 184036-34-8 C18H15ClN2O6S2 454.9
Omecamtiv mecarbil 873697-71-3 C20H24FN5O3 401.43
Tadalafil 171596-29-5 C22H19N3O4 389.4
Sildenafil (citrate) 171599-83-0 C28H38N6O11S 666.7
Cinaciguat 329773-35-5 C36H39NO5 565.7
Milrinone 78415-72-2 C12H9N3O 211.22
Istaroxime (hydrochloride) 374559-48-5 C21H33ClN2O3 396.95
Riociguat 625115-55-1 C20H19FN8O2 422.42
Sildenafil 139755-83-2 C22H30N6O4S 474.58
Tolvaptan 150683-30-0 C26H25ClN2O3 448.94
Istaroxime 203737-93-3 C21H32N2O3 360.49
Sitaxsentan (sodium) 210421-74-2 C18H14ClN2NaO6S2 476.89
Bosentan 147536-97-8 C27H29N5O6S 551.61
Clevidipine 167221-71-8 C21H23Cl2NO6 456.3164
Bosentan (hydrate) 157212-55-0 C27H31N5O7S 569.63
AHU-377 (hemicalcium salt) 1369773-39-6 C24H28NO5- 410.48
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Route of Synthesis

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References

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More Information

Ambrisentan

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