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42971-09-5 (Vinpocetine)

1

Identification

Vinpocetine Vinpocetine
Name Vinpocetine
Formula C22H26N2O2
MW 350.45
CAS No. 42971-09-5
EINECS 256-028-0
Smiles CC[[email protected]@]1(CCC2)[[email protected]@](N2CC3)([H])C4=C3C5=C(C=CC=C5)N4C(C(OCC)=O)=C1
Synonyms Ethyl (3alpha,16alpha)-eburnamenine-14-carboxylate; (41S,13aS)-ethyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate
InChI InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
2

Introduction

Vinpocetine(Cavinton; Ethyl apovincaminate) is a selective for PDE1 (IC50 = 21 μM).

Background Information

Vinpocetine, isolated from the lesser periwinkle plant, is a derivative of the vinca alkaloid vincamine with an effect of cerebral blood-flow enhancing and neuroprotection. Vinpocetine was approved for the treatment of cerebrovascular disorders and age-re ......by BOC Sciences
Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. ......by Selleck Chemicals LLC
Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE). ......by Target Molecule Corp.
Phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028621

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO <1 mg/mL (<1 mM); Water<1 mg/mL (<1 mM); Ethanol<! mg/mL <! by Selleck Chemicals LLC
Soluble to 50 mM in ethanol and to 10 mM in DMSO with gentle warming by Tocris Bioscience Inc.
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Vinpocetine - Launched
Vinpocetine Noscira SA Progressive supranuclear palsy 2009/12/31 2011/11/30 Phase 2 Clinical
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Safety Data of Vinpocetine

Hazard Symbols : Xn
Risk Statements : R22
Safety Statements : S36
RTECS : JW4792000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Asia Talent Chemical Limited China
BOC Sciences
Boehringer Ingelheim GmbH Germany
CHEMSCENE, LLC 50mg/USD60();100mg/USD79() USA
Changsha Nutramax Inc. China
Guangzhou Greensyn Co., Ltd. China
Haikou Hengkangda Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD60();100mg/USD79() USA
Rota Pharm & Chem Co., Ltd. China
SNI Nutrition Co., Ltd. China
Selleck Chemicals LLC 20mg/USD97(In stock);100mg/USD270(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD60();100mg/USD79() China
Target Molecule Corp. 2mg/USD20();10mg/USD75();20mg/USD125();100mg/USD325() USA
Tianjin Port Free Trade Zone Bettle Science and Technology Co., Ltd. China
Tocris Bioscience Inc. USA
Wuxi Cima Science Co., Ltd. China
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Related Products

Other Forms of 42971-09-5

Name CAS No Formula MW

Recommended Compounds in Phosphodiesterase (PDE) Sodium Channel

Name CAS No Formula MW
(R)-(-)-Rolipram 85416-75-7 C16H21NO3 275.34
Mirodenafil (dihydrochloride) 862189-96-6 C26H39Cl2N5O5S 604.59
Vardenafil (hydrochloride) 224785-91-5 C23H33ClN6O4S 525.06
Ibudilast 50847-11-5 C14H18N2O 230.31
Pentoxifylline 6493-05-6 C13H18N4O3 278.31
Anagrelide (hydrochloride) 58579-51-4 C10H8Cl3N3O 292.55
Vardenafil 224785-90-4 C23H32N6O4S 488.6
(S)-(+)-Rolipram 85416-73-5 C16H21NO3 275.34
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Dipyridamole (hydrochloride)(1:x) 35763-39-4 C24H41ClN8O4 541.09
Dipyridamole 58-32-2 C24H40N8O4 504.63
Pimobendan (hydrochloride) 77469-98-8 C19H19ClN4O2 370.83
Pimobendan 74150-27-9 C19H18N4O2 334.37
Aminophylline 317-34-0 C16H24N10O4 420.43
Diphylline 479-18-5 C10H14N4O4 254.24
Cilostazol 73963-72-1 C20H27N5O2 369.46
Deltarasin (hydrochloride) 1440898-82-7 C40H38ClN5O 640.22
Rolipram 61413-54-5 C16H21NO3 275.34
Deltarasin 1440898-61-2 C40H37N5O 603.75

Recommended Compounds in Same Indication

Name CAS No Formula MW
Tideglusib 865854-05-3 C19H14N2O2S 334.39
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Route of Synthesis

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References

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More Information

Vinpocetine

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