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163521-08-2 (Vilazodone (Hydrochloride))

1

Identification

Vilazodone (Hydrochloride) Vilazodone (Hydrochloride)
Name Vilazodone (Hydrochloride)
Formula C26H28ClN5O2
MW 477.99
CAS No. 163521-08-2
EINECS 200-659-6
Smiles NC(C1=CC2=C(C=CC(N3CCN(CCCCC4=CNC5=CC=C(C=C54)C#N)CC3)=C2)O1)=O.[H]Cl
Synonyms EMD 68843;SB 659746A;EMD-68843;EMD68843;SB-659746A;SB659746A; 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide hydrochloride
InChI InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32;/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32);1H
2

Introduction

Vilazodone Hcl (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. IC50 value: Target: SSRI; 5-HT1A Vilazodone represents another option for the treatment of MDD.

Background Information

Vilazodone HCl is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder. ......by Selleck Chemicals LLC
Vilazodone HCl is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000028617

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 96 mg/mL (200.84 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Vilazodone (Hydrochloride) Thomas Jefferson University Major depressive disorder 2013/1/31 2015/6/30 Phase 4 Clinical
Vilazodone (Hydrochloride) Thomas Jefferson University Sexual dysfunction 2013/1/31 2015/6/30 Phase 4 Clinical
Vilazodone (Hydrochloride) Southern California Institute for Research and Education Post traumatic stress disorder 2012/10/31 2014/4/30 Phase 4 Clinical
Vilazodone (Hydrochloride) University of California Los Angeles Depression 2012/7/31 2014/5/31 Phase 4 Clinical
Vilazodone (Hydrochloride) Forest Laboratories Inc Depression 2012/4/30 2015/1/31 Phase 4 Clinical
Vilazodone (Hydrochloride) Forest Laboratories Inc Depression 2011/11/30 2013/4/1 Phase 4 Clinical
Vilazodone (Hydrochloride) - Launched
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Safety Data of Vilazodone (Hydrochloride)

Hazard Symbols : F,T
Risk Statements : 11-23/24/25-39/23/24/25
Safety Statements : 7-16-36/37-45
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
BOC Sciences
Beijing Huikang Boyuan Chemical Tech Co., Ltd. China
Beijing Mesochem Technology Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD60();50mg/USD98() USA
MedChemexpress Co., Ltd. 10mg/USD60();50mg/USD98() USA
NOVASYNCS Co., Ltd. China
Reco Tech Limited China
Selleck Chemicals LLC 50mg/USD97(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD60();50mg/USD98() China
Target Molecule Corp. 2mg/USD24();10mg/USD44();50mg/USD148() USA
Wuhan Sunrise Technology Development Company Limited China
Yitai Pharmatech Co., Ltd. China
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Related Products

Other Forms of 163521-08-2

Name CAS No Formula MW
Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 477.9858

Recommended Compounds in Serotonin Transporter 5-HT Receptor

Name CAS No Formula MW
Doxepin (Hydrochloride) 1229-29-4 C19H22ClNO 315.84
Duloxetine (hydrochloride) 136434-34-9 C18H20ClNOS 333.8755
Paroxetine (hydrochloride hemihydrate) 110429-35-1 C19H21ClFNO3 365.83
Fluoxetine 54910-89-3 C17H18F3NO 309.33
Desvenlafaxine 93413-62-8 C16H25NO2 263.38
Paroxetine (hydrochloride) 78246-49-8 C19H21ClFNO3 365.83
Dapoxetine (hydrochloride) 129938-20-1 C9H7ClN2O5 258.62
Venlafaxine (hydrochloride) 99300-78-4 C17H28ClNO2 313.86
Venlafaxine 93413-69-5 C17H27NO2 277.4
Escitalopram (oxalate) 219861-08-2 C22H23FN2O5 414.43
Sertraline (hydrochloride) 79559-97-0 C17H18Cl3N 342.69
Milnacipran (hydrochloride) 101152-94-7 C15H23ClN2O 282.81
(1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 92623-85-3 C15H22N2O 246.35
Duloxetine (hydrochloride) 136434-34-9 C18H20ClNOS 333.88
Fluvoxamine (maleate) 61718-82-9 C19H25F3N2O6 434.41
Fluvoxamine 54739-18-3 C15H21F3N2O2 318.33
Fluoxetine (hydrochloride) 56296-78-7 C17H19ClF3NO 345.79
Azaphen (dihydrochloride monohydrate) 63302-99-8 C16H23Cl2N5O2 388.29
Sibutramine (hydrochloride monohydrate) 125494-59-9 C17H29Cl2NO 334.32
Sibutramine (hydrochloride) 84485-00-7 C17H27Cl2N 316.31

Recommended Compounds in Same Indication

Name CAS No Formula MW
Iloperidone 133454-47-4 C24H27FN2O4 426.48
Tianeptine 72797-41-2 C21H25ClN2O4S 436.95
Cariprazine 839712-12-8 C21H32Cl2N4O 427.41
Asenapine 65576-45-6 C17H16ClNO 285.77
Asenapine (maleate) 85650-56-2 C21H20ClNO5 401.84
Vortioxetine 508233-74-7 C18H22N2S 298.45
Tasimelteon 609799-22-6 C15H19NO2 245.3169
Rolipram 61413-54-5 C16H21NO3 275.34
Nepicastat (hydrochloride) 170151-24-3 C14H16ClF2N3S 331.8117
Mifepristone 84371-65-3 C29H35NO2 429.59
Zolpidem 82626-48-0 C19H21N3O 307.39
Nepicastat 173997-05-2 C14H15F2N3S 295.35
Curcumin 458-37-7 C21H20O6 368.38
Agomelatine 138112-76-2 C15H17NO2 243.3
NSI-189 1270138-40-3 C22H30N4O 366.5
Tianeptine (sodium salt) 30123-17-2 C21H24ClN2NaO4S 458.93
Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 477.9858
Quetiapine (fumarate) 111974-72-2 C46H54N6O8S2 883.09
Rapastinel 117928-94-6 C18H31N5O6 413.47
JNJ-40411813 1127498-03-6 C20H25ClN2O 344.88
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Route of Synthesis

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References

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More Information

Vilazodone (Hydrochloride)

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