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75507-68-5 (Flupirtine (Maleate))

1

Identification

Flupirtine (Maleate) Flupirtine (Maleate)
Name Flupirtine (Maleate)
Formula C19H21FN4O6
MW 420.39
CAS No. 75507-68-5
EINECS 278-225-0
Smiles O=C(NC1=CC=C(N=C1N)NCC2=CC=C(C=C2)F)OCC.O=C(/C=CC(O)=O)O
Synonyms ethyl (2-amino-6-((4-fluorobenzyl)amino)pyridin-3-yl)carbamate maleate
InChI InChI=1S/C15H17FN4O2.C4H4O4/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;5-3(6)1-2-4(7)8/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1-
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Introduction

Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. IC50 Value: Target: Potassium channel; NMDA receptor in vitro: High concentrations of flupirtine antagonized inward currents to NMDA(200 microM) at -70 mV with an lC50 against steady-state responses of 182.1+/-12.1 microM.

Background Information

Non-opioid analgesic with muscle relaxant properties. ......by AdooQ BioScience, LLC
Flupirtine Maleate is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. ......by BOC Sciences
Flupirtine, also known as W-2964, is an aminopyridine that functions as a centrally acting non-opioid analgesic. It first became available in Europe in 1984, and is sold mainly under the names Katadolon, Trancolong, Awegal, Efiret, Trancopal Dolo, and Metanor. Like nefopam, it is unique among analgesics in that it is a non-opioid, non-NSAID, non-steroidal centrally acting analgesic. Flupirtine is a selective neuronal potassium channel opener that also has NMDA receptor antagonist and GABAA receptor modulatory properties. ......by MedKoo Biosciences, Inc.
A selective neuronal potassium channel (KCNQ/KV7 channel) activator that also has indirect NMDA receptor antagonist and GABAA receptor modulatory properties; a centrally acting non-opioid analgesic used as an analgesic for acute and chronic pain.PainDiscontinued ......by ProbeChem
Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. ......by Selleck Chemicals LLC
Flupirtine maleate is the salt form of Flupirtine, which is a centrally acting non-opioid analgesia, is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. ......by Target Molecule Corp.
Non-opioid analgesic with muscle relaxant properties. Activates KV7 potassium channels, indirectly antagonizes NMDA receptors and modulates GABAA receptors. Exhibits neuroprotective actions in a model of cerebral ischemia in mice and reduces apoptosis and necrosis induced by noxious stimuli. Deuterated analog also available. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000028593

Storage condition

Solubility

DMSO 84 mg/mL (199 mM) ; Water <1 mg/mL (<1 mM) ; Ethanol 3 mg/mL (7 mM) by Selleck Chemicals LLC
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Mechanism and Indication

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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Flupirtine (Maleate) - Discontinued
Flupirtine (Maleate) - Launched
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Safety Data of Flupirtine (Maleate)

Safety Statements : 22-24/25
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 75507-68-5

Name CAS No Formula MW
Flupirtine 56995-20-1 C15H17FN4O2 304.32

Recommended Compounds in iGluR Potassium Channel

Name CAS No Formula MW
PEAQX 459836-30-7 C17H17BrN3O5P 454.2117
Dextromethorphan (hydrobromide) 125-69-9 C18H26BrNO 352.31
Piracetam 7491-74-9 C6H10N2O2 142.16
Meclofenoxate (hydrochloride) 3685-84-5 C12H17Cl2NO3 294.17
Coluracetam 135463-81-9 C19H23N3O3 341.4
NMDA 6384-92-5 C5H9NO4 147.13
Sunifiram 314728-85-3 C14H18N2O2 246.3
SDZ 220-581 (hydrochloride) 179411-93-9 C16H18Cl2NO5P 406.2
Orphenadrine (citrate) 4682-36-4 C24H31NO8 461.5
Memantine (hydrochloride) 41100-52-1 C12H22ClN 215.76
Ro 25-6981 (Maleate) 1312991-76-6 C26H33NO6 455.54
Ro 25-6981 169274-78-6 C22H29NO2 339.47
Felbamate (hydrate) 1177501-39-1 C11H16N2O5 256.26
Felbamate 25451-15-4 C11H14N2O4 238.24
Flupirtine 56995-20-1 C15H17FN4O2 304.32
Noopept 157115-85-0 C17H22N2O4 318.37
QNZ46 1237744-13-6 C24H17N3O6 443.4083
SDZ 220-581 (Ammonium salt) 179411-94-0 C16H20ClN2O5P 386.77
MDL-29951 130798-51-5 C12H9Cl2NO4 302.11
MDL 105519 161230-88-2 C18H11Cl2NO4 376.19

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Flupirtine (Maleate)

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