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69004-04-2 (Toltrazuril (sulfone))

1

Identification

Toltrazuril (sulfone) Toltrazuril (sulfone)
Name Toltrazuril (sulfone)
Formula C18H14F3N3O6S
MW 457.38
CAS No. 69004-04-2
EINECS
Smiles O=S(C1=CC=C(C=C1)OC2=C(C=C(C=C2)N3C(N(C(NC3=O)=O)C)=O)C)(C(F)(F)F)=O
Synonyms Ponazuril; 1-methyl-3-(3-methyl-4-(4-((trifluoromethyl)sulfonyl)phenoxy)phenyl)-1,3,5-triazinane-2,4,6-trione
InChI InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
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Introduction

Toltrazuril sulfone is an antiprotozoal agent that acts upon Coccidia parasites. IC50 Value: Target: Antiparasitic Ponazuril (INN, Toltrazuril sulfone), sold by the Bayer Corporation under the trade name Marquis, is a drug currently approved for the treatment of equine protozoal myeloencephalitis in horses, caused by Sarcocystis neurona.

Background Information

Ponazuril, also known as Toltrazuril sulfone, is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by Sarcocystis neurona. More recently, veterinarians have been preparing a formulary version of the medication for use in small animals such as cats and dogs against coccidia, an intestinal parasite. Coccidia treatment is far shorter than treatment for EPM. ......by MedKoo Biosciences, Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028551

Storage condition

Solubility

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Mechanism and Indication

Signaling Pathways Anti-infection
Target Parasite
Research Area Infection
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Toltrazuril (sulfone) - Not Found
Toltrazuril (sulfone) - No Development Reported
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Safety Data of Toltrazuril (sulfone)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD114();10mg/USD166() USA
CacheSyn Inc. Canada
MedChemexpress Co., Ltd. 5mg/USD114();10mg/USD166() USA
MedKoo Biosciences, Inc. USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD114();10mg/USD166() China
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Related Products

Other Forms of 69004-04-2

Name CAS No Formula MW
Toltrazuril 69004-03-1 C18H14F3N3O4S 425.38

Recommended Compounds in Parasite

Name CAS No Formula MW
Buparvaquone 88426-33-9 C21H26O3 326.43
milbemycin oxime 129496-10-2 C126H176N4O28 2194.76
Moxidectin 113507-06-5 C37H53NO8 639.82
Amprolium (hydrochloride) 137-88-2 C14H20Cl2N4 315.24
Bruceine A 25514-31-2 C26H34O11 522.54
GNF179 (Metabolite) 1310455-86-7 C14H16FN3 245.3
GNF179 1261114-01-5 C22H23ClFN5O 427.9
Artemotil 75887-54-6 C17H28O5 312.4012
Fumagillin 23110-15-8 C26H34O7 458.54
Ronidazole 7681-76-7 C6H8N4O4 200.15
Pentamidine (dihydrochloride) 50357-45-4 C19H26Cl2N4O2 413.34
Pentamidine 100-33-4 C19H24N4O2 340.42
Ornidazole 16773-42-5 C7H10ClN3O3 219.63
Clorsulon 60200-06-8 C8H8Cl3N3O4S2 380.66
Sulfadoxine 2447-57-6 C12H14N4O4S 310.33
Quinine (hydrochloride dihydrate) 6119-47-7 C20H29ClN2O4 396.91
Fenbendazole 43210-67-9 C15H13N3O2S 299.35
Haloxon 321-55-1 C14H14Cl3O6P 415.5901
Diclazuril 101831-37-2 C17H9Cl3N4O2 407.64
Metronidazole 443-48-1 C6H9N3O3 171.15

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Toltrazuril (sulfone)

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