• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

94497-51-5 (Tamibarotene)

1

Identification

Tamibarotene Tamibarotene
Name Tamibarotene
Formula C22H25NO3
MW 351.44
CAS No. 94497-51-5
EINECS
Smiles O=C(C1=CC=C(C=C1)C(NC2=CC=C3C(C)(CCC(C)(C3=C2)C)C)=O)O
Synonyms Am80;Am 80;Am-80; 4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid
InChI InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
2

Introduction

Tamibarotene(Am-80) is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro.

Background Information

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. ......by AdooQ BioScience, LLC
Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute ......by BOC Sciences
Tamibarotene is an agonist for retinoic acid receptor α/β, and used for cancer treatment. ......by MedChemexpress Co., Ltd.
Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA. ......by MedKoo Biosciences, Inc.
Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. ......by Selleck Chemicals LLC
Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. ......by Target Molecule Corp.
Retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000028512

Storage condition

Store at RT by Tocris Bioscience Inc.

Solubility

(25°C) * In vitro DMSO 70 mg/mL (199.18 mM); Ethanol70 mg/mL (199.18 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in 1.1eq. NaOH and to 50 mM in DMSO by Tocris Bioscience Inc.
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tamibarotene St Marianna University School of Medicine Tropical spastic paraparesis 2011/1/31 2012/3/31 Phase 3 Clinical
Tamibarotene CytRx Corp Metastatic non small cell lung cancer 2011/4/30 2013/6/30 Phase 2 Clinical
Tamibarotene Kinki University Lupus nephritis 2010/9/30 2013/2/28 Phase 2 Clinical
Tamibarotene Osaka City University Alzheimers disease 2010/5/31 2012/12/31 Phase 2 Clinical
Tamibarotene National Institute of Cancerología Carcinoma 2007/9/30 2009/11/30 Phase 2 Clinical
Tamibarotene National Institute of Cancerología Non-small-cell lung cancer 2007/9/30 2009/11/30 Phase 2 Clinical
Tamibarotene - Launched
7

Safety Data of Tamibarotene

8

Spectral Information

9

Suppliers List

10

Related Products

Other Forms of 94497-51-5

Name CAS No Formula MW

Recommended Compounds in RAR/RXR

Name CAS No Formula MW
AGN 205728 859498-05-8 C29H27NO3 437.53
AGN 196996 958295-17-5 C24H20BrNO5 482.32
AGN 194310 229961-45-9 C28H24O2S 424.55
Acitretin (sodium) 925701-88-8 C21H25NaO3 348.41
Acitretin 55079-83-9 C21H26O3 326.43
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 434.5
Adapalene 106685-40-9 C28H28O3 412.52
TTNPB 71441-28-6 C24H28O2 348.48
Magnolol 528-43-8 C18H18O2 266.33
Tazarotene 118292-40-3 C21H21NO2S 351.46
Fenretinide 65646-68-6 C26H33NO2 391.55
LG 100268 153559-76-3 C24H29NO2 363.49
Isotretinoin 4759-48-2 C20H28O2 300.44
Palovarotene 410528-02-8 C27H30N2O2 414.54
Retinoic acid 302-79-4 C20H28O2 300.44
AM580 102121-60-8 C22H25NO3 351.44
(R)-Flurbiprofen 51543-40-9 C15H13FO2 244.2609
Bexarotene 153559-49-0 C24H28O2 348.48
AGN 195183 367273-07-2 C22H22ClF2NO4 437.86
AR7 80306-38-3 C15H12ClNO 0.0

Recommended Compounds in Same Indication

Name CAS No Formula MW
LDK378 1032900-25-6 C28H36ClN5O3S 558.14
Pemetrexed (disodium) 150399-23-8 C20H19N5Na2O6 471.37
Lu AE58054 467459-31-0 C20H19F5N2O 398.37
EVP-6124 550999-75-2 C16H17ClN2OS 320.84
Volasertib 755038-65-4 C34H50N8O3 618.81
ALK inhibitor 1 761436-81-1 C23H28BrN7O3S 562.48
Olaparib 763113-22-0 C24H23FN4O3 434.46
Afatinib (dimaleate) 850140-73-7 C32H33ClFN5O11 718.08
MGCD-265 analog 875337-44-3 C26H20FN5O2S2 517.5977
Crizotinib 877399-52-5 C21H22Cl2FN5O 450.34
AT-101 90141-22-3 C30H30O8 518.55
Tivantinib 905854-02-6 C23H19N3O2 369.42
Dovitinib 405169-16-6 C21H21FN6O 392.43
Sunitinib 557795-19-4 C22H27FN4O2 398.47
Tideglusib 865854-05-3 C19H14N2O2S 334.39
N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide 414864-00-9 C15H14N2O4S 318.34766
Cilostazol 73963-72-1 C20H27N5O2 369.46
Retaspimycin 857402-23-4 C31H45N3O8 587.7
Retaspimycin (Hydrochloride) 857402-63-2 C31H46ClN3O8 624.17
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 569.44
11

Route of Synthesis

12

References

13

More Information

Tamibarotene

Tags: buy 94497-51-5 IC50 | 94497-51-5 price | 94497-51-5 cost | 94497-51-5 solubility | 94497-51-5 purchase | 94497-51-5 manufacturer | 94497-51-5 research buy | 94497-51-5 order | 94497-51-5 MSDS | 94497-51-5 chemical structure | 94497-51-5 Storage condition | 94497-51-5 molecular weight | 94497-51-5 mw | 94497-51-5 datasheet | 94497-51-5 supplier | 94497-51-5 cell line | 94497-51-5 NMR | 94497-51-5 MS | 94497-51-5 IR | 94497-51-5 solubility | 94497-51-5 Safe information | 94497-51-5 Qc and Spectral Information | 94497-51-5 Clinical Information | 94497-51-5 Clinical Trial | 94497-51-5 Route of Synthesis | 94497-51-5 storage condition | 94497-51-5 diseases and conditions | 94497-51-5 flash point | 94497-51-5 boiling point | 94497-51-5 melting point | 94497-51-5 storage condition | 94497-51-5 brand