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148408-66-6 (Docetaxel (Trihydrate))

1

Identification

Docetaxel (Trihydrate) Docetaxel (Trihydrate)
Name Docetaxel (Trihydrate)
Formula C43H59NO17
MW 861.93
CAS No. 148408-66-6
EINECS
Smiles O=C1[[email protected]@]2(C)[[email protected]]([[email protected]](OC(C3=CC=CC=C3)=O)[[email protected]](C4(C)C)(O)C[[email protected]](OC([[email protected]](O)[[email protected]](C5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)C(C)=C4[[email protected]]1O)([H])[[email protected]]6(OC(C)=O)CO[[email protected]]6([H])C[[email protected]@H]2O.O.O.O
Synonyms (2aR,4S,4aS,6R,9S,11S,12S,12aS,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate trihydrate
InChI InChI=1S/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32+,33+,35-,41+,42-,43+;;;/m0.../s1
2

Introduction

Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. IC50 Value: Target: Microtubule/Tubulin in vitro: IC50 concentrations (reducing survival by 50%) ranged from 0.13-3.3 ng/ml, with three neuroblastoma lines proving most sensitive and three breast and two colon carcinoma lines showing least sensitivity [1].

Background Information

Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. ......by AbMole BioScience
Docetaxel trihydrate, an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules. ......by AdooQ BioScience, LLC
Docetaxel is a cytotoxic agent, which is related to its ability to promote the formation of microtubule bundles and induce sustained mitotic arrest, followed by apoptosis of mitotically arrested cells or permanent mitotic block. ......by BOC Sciences
Docetaxel Trihydrate is a semi-synthetic taxane analogue, acts as a microtubule stabilizer. ......by MedChemexpress Co., Ltd.
Docetaxel, also known as RP-56976, is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. ......by MedKoo Biosciences, Inc.
Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. ......by Selleck Chemicals LLC
Docetaxel, an analog of taxol, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000024651

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Cell Cycle/DNA Damage Cytoskeleton
Target Microtubule/Tubulin
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Docetaxel (Trihydrate) - Not Found
Docetaxel (Trihydrate) - No Development Reported
Docetaxel (Trihydrate) - Launched
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Safety Data of Docetaxel (Trihydrate)

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Spectral Information

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Suppliers List

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Related Products

Other Forms of 148408-66-6

Name CAS No Formula MW
Docetaxel 114977-28-5 C43H53NO14 807.88

Recommended Compounds in Microtubule/Tubulin

Name CAS No Formula MW
MMAD (hydrochloride) 173441-26-4 C41H67ClN6O6S 807.5253
7-Epi-docetaxel 153381-68-1 C43H53NO14 807.88
7-Epi-10-oxo-docetaxel 162784-72-7 C43H51NO14 805.86
10-Oxo Docetaxel 167074-97-7 C43H51NO14 805.86
MMAF (Hydrochloride) 1415246-68-2 C39H66ClN5O8 768.42
Tubulysin A 205304-86-5 C43H65N5O10S 844.07
Vinflunine 162652-95-1 C45H54F2N4O8 816.93
Triclabendazole 68786-66-3 C14H9Cl3N2OS 359.66
Eribulin mesylate 441045-17-6 C41H63NO14S 826.0
Vincristine (sulfate) 2068-78-2 C46H58N4O14S 923.04
Vc-MMAD 1401963-17-4 C70H104N12O14S 1369.71
Mc-MMAE 863971-24-8 C49H78N6O10 911.18
Mc-MMAD 1401963-15-2 C51H77N7O9S 964.26
Vinorelbine (ditartrate) 125317-39-7 C53H66N4O20 1079.11
Fosbretabulin (disodium) 168555-66-6 C18H19Na2O8P 440.29
4'-Demethylepipodophyllotoxin 6559-91-7 C21H20O8 400.38
Vinblastine 865-21-4 C46H58N4O9 810.97
Vinblastine (sulfate) 143-67-9 C46H60N4O13S 909.05
Tasidotin hydrochloride 623174-20-9 C32H59ClN6O5 643.3
Taltobulin 228266-40-8 C27H43N3O4 473.64802

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Docetaxel (Trihydrate)

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