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618385-01-6 (Vorapaxar)

1

Identification

Vorapaxar Vorapaxar
Name Vorapaxar
Formula C29H33FN2O4
MW 492.58
CAS No. 618385-01-6
EINECS
Smiles O=C(O[[email protected]@H]1C)[[email protected]@]2([H])[[email protected]]1([H])[[email protected]@H](/C=C/C3=NC=C(C=C3)C4=CC=CC(F)=C4)[[email protected]]([[email protected]](C5)([H])C2)([H])CC[[email protected]]5NC(OCC)=O
Synonyms ethyl ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate
InChI InChI=1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1
2

Introduction

Background Information

SCH-530348 is a novel antiplatelet agent undergoing development by Schering-Plough Corp for the treatment and prevention of atherothrombosis. It is currently undergoing Phase-III clinical trials for acute coronary syndrome (unstable angina/non-ST segment ......by BOC Sciences
Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM. ......by Selleck Chemicals LLC
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models cynomolgus monkeys
Dosage 0.5, 0.3, 0.1, and 0.05 mg/kg
Formulation 0.4% methyl cellulose
Administration oral
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000024515

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.

Solubility

DMSO: > 30 mg/mL by CHEMSCENE, LLC
DMSO: > 30 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 99 mg/mL (200.98 mM); Ethanol99 mg/mL (200.98 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Vorapaxar Merck Sharp & Dohme Corp. Atherosclerosis Myocardial Ischemia Myocardial Infarction 2007/9/7 2015/10/1 Phase 3 Clinical
Vorapaxar Merck Sharp & Dohme Corp. Cerebral Infarction 2008/5/22 2015/10/1 Phase 3 Clinical
Vorapaxar - Launched
7

Safety Data of Vorapaxar

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 5mg/USD250();10mg/USD380() USA
AdooQ BioScience, LLC 5mg/USD150();10mg/USD250();25mg/USD500();50mg/USD750() USA
Apexbio Technology LLC 5mg/USD200();10mg/USD300();25mg/USD600();50mg/USD850() USA
Axon Medchem BV 5mg/USD210();25mg/USD840() Netherlands
BOC Sciences 10mg/USD198(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD168();10mg/USD288() USA
MedChemexpress Co., Ltd. 5mg/USD168();10mg/USD288() USA
Selleck Chemicals LLC 5mg/USD170();25mg/USD670() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD168();10mg/USD288() China
10

Related Products

Other Forms of 618385-01-6

Name CAS No Formula MW
TIN PROTOPORPHYRIN IX DICHLORIDE 14325-05-4 C34H36Cl2N4O4Sn 754.29
(+/-)-TROPANYL 2-(4-CHLOROPHENOXY)BUTANOATE MALEATE 155059-42-0 C22H28ClNO7 453.91
D-Erythro-dihydrosphingosine 764-22-7 C18H39NO2 301.51
Zinc protoporphyrin 15442-64-5 C34H32N4O4Zn 626.02228
Clobenpropit (dihydrobromide) 145231-35-2 C14H19Br2ClN4S 470.65346
N-Benzylnaltrindole (hydrochloride) 1206487-81-1 C33H33ClN2O3 0.0
PG 9 (maleate) 155649-00-6 C21H26BrNO6 0.0
GSK682753A 1334294-76-6 C23H21Cl3N2O3 0.0
Ecteinascidin 770 114899-80-8 C40H42N4O10S 0.0
Volixibat 1025216-57-2 C38H51N3O12S2 0.0

Recommended Compounds in Protease-Activated Receptor (PAR)

Name CAS No Formula MW
AC-55541 916170-19-9 C25H20BrN5O3 518.362
TRAP-6 141136-83-6 C34H56N10O9 748.87
TFLLR-NH2 197794-83-5 C31H53N9O6 647.81
Protease-Activated Receptor-2, amide C28H54N8O7 614.8
Protease-Activated Receptor-4 C33H46N8O7 666.77
AZ3451 2100284-59-9 C30H27BrN4O3 571.46
AZ8838 2100285-41-2 C13H15FN2O 234.27
GB83 1252806-86-2 C32H44N4O4 548.72
GB88 1416435-96-5 C32H42N4O4 546.7
AY117 1357249-44-5 C30H42N4O4 522.68
SB89 2227508-24-7 C20H20FNO3 341.38
SB70 2227508-20-3 C20H20FNO3 341.38
AZ6343 C11H14N2O 190.24
AZ7188 31951-29-8 C17H14N2O 262.31
GB110 1252806-70-4 C33H48N6O5 608.77

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Vorapaxar

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