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618385-01-6 (Vorapaxar)

1

Identification

Vorapaxar Vorapaxar
Name Vorapaxar
Formula C29H33FN2O4
MW 492.58
CAS No. 618385-01-6
EINECS
Smiles O=C(O[[email protected]@H]1C)[[email protected]@]2([H])[[email protected]]1([H])[[email protected]@H](/C=C/C3=NC=C(C=C3)C4=CC=CC(F)=C4)[[email protected]]([[email protected]](C5)([H])C2)([H])CC[[email protected]]5NC(OCC)=O
Synonyms ethyl ((1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate
InChI InChI=1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1
2

Introduction

Background Information

SCH-530348 is a novel antiplatelet agent undergoing development by Schering-Plough Corp for the treatment and prevention of atherothrombosis. It is currently undergoing Phase-III clinical trials for acute coronary syndrome (unstable angina/non-ST segment ......by BOC Sciences
Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM. ......by Selleck Chemicals LLC
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models cynomolgus monkeys
Dosage 0.5, 0.3, 0.1, and 0.05 mg/kg
Formulation 0.4% methyl cellulose
Administration oral
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000024515

Storage condition

Store in a tightly closed container, in a cool and dry place. by MedChemexpress Co., Ltd.

Solubility

DMSO: > 30 mg/mL by CHEMSCENE, LLC
DMSO: > 30 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 99 mg/mL (200.98 mM); Ethanol99 mg/mL (200.98 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Vorapaxar Merck Sharp & Dohme Corp. Atherosclerosis Myocardial Ischemia Myocardial Infarction 2007/9/7 2015/10/1 Phase 3 Clinical
Vorapaxar Merck Sharp & Dohme Corp. Cerebral Infarction 2008/5/22 2015/10/1 Phase 3 Clinical
Vorapaxar - Launched
7

Safety Data of Vorapaxar

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience 5mg/USD250();10mg/USD380() USA
AdooQ BioScience, LLC 5mg/USD150();10mg/USD250();25mg/USD500();50mg/USD750() USA
Apexbio Technology LLC 5mg/USD200();10mg/USD300();25mg/USD600();50mg/USD850() USA
Axon Medchem BV 5mg/USD210();25mg/USD840() Netherlands
BOC Sciences 10mg/USD198(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD168();10mg/USD288() USA
MedChemexpress Co., Ltd. 5mg/USD168();10mg/USD288() USA
Selleck Chemicals LLC 5mg/USD170();25mg/USD670() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD168();10mg/USD288() China
10

Related Products

Other Forms of 618385-01-6

Name CAS No Formula MW
TIN PROTOPORPHYRIN IX DICHLORIDE 14325-05-4 C34H36Cl2N4O4Sn 754.29
(+/-)-TROPANYL 2-(4-CHLOROPHENOXY)BUTANOATE MALEATE 155059-42-0 C22H28ClNO7 453.91
D-​Erythro-​dihydrosphingosine 764-22-7 C18H39NO2 301.50776
Zinc protoporphyrin 15442-64-5 C34H32N4O4Zn 626.02228
Clobenpropit (dihydrobromide) 145231-35-2 C14H19Br2ClN4S 470.65346
N-Benzylnaltrindole (hydrochloride) 1206487-81-1 C33H33ClN2O3 0.0
PG 9 (maleate) 155649-00-6 C21H26BrNO6 0.0
GSK682753A 1334294-76-6 C23H21Cl3N2O3 0.0
Ecteinascidin 770 114899-80-8 C40H42N4O10S 0.0
Volixibat 1025216-57-2 C38H51N3O12S2 0.0

Recommended Compounds in Protease-Activated Receptor (PAR)

Name CAS No Formula MW
AC-55541 916170-19-9 C25H20BrN5O3 518.362
TRAP-6 141136-83-6 C34H56N10O9 748.87
TFLLR-NH2 197794-83-5 C31H53N9O6 647.81
Protease-Activated Receptor-2, amide C28H54N8O7 614.8
Protease-Activated Receptor-4 C33H46N8O7 666.77
AZ3451 C30H27BrN4O3 571.46
AZ8838 C13H15FN2O 234.27
SB89 C20H20FNO3 341.38
SB70 C20H20FNO3 341.38
AZ6343 C11H14N2O 190.24
AZ7188 C17H14N2O 262.31
GB110 C33H48N6O5 608.77

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Vorapaxar

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